BigCatDaddy2
New member
Let me guess….going over 1600 can mess with your stomach?
How to cycle 3 months peptides with 1 month mk677, from baseline 227 to 406 IGF-1 equivalent to 4.3iu pharm grade HGH.
- Thread starter tregar
- Start date
Smont
Legend
Toxicity over 1600mg in a animal study that the translated doses to humans and then I believe there was a couple other issues for some ppl in higher doses as well. I've used 2500mg a day for a month but after seeing a few things I just do 1500 to be safe. 500 3×day is probably the most common way I've used it. I like adding cinnamon to anything I can too. It also helps with insulin sensitivity
tregar
Member
I've taken 1 and 1/4 year off from mk677 and/or peptides and just lifted normal (210mg test cyp a week hormone replacement). I'm now planning to use peptide shots only for a while. I like to change things up a bit now and then. I have not used mk677 or peptide shots at all for 1.25 year.
x3me said (from page 2 bottom):
Tregar here, checking in after a year as usual.
I saw some mis-information one page back, where someone said that mk677 affects cortisol levels. No, mk677 does not affect cortisol levels whatsoever. And if it did, I would never use it, as anything that raises your cortisol levels will also cause you to wake up "too early" every day, etc. That would not be fun. Also, mod grf 1-29 + ipamorelin (peptide shots) also does not affect your cortisol in any way. Definite advantage to either one of these you might choose.
In answer to x3me, No, there are no oral peptides other than mk677. There is absolutely nothing wrong with using shots x 3 times a day, no side effects and works forever without losing potency, just that you need to (1) pre-prepare the shots ahead of time, so that you can take one to work if you are using x 3 times a day, and (2) they are more costly. ** * peptides has one of the best offerings that I have seen over the years. Don't get trapped into thinking mk677 is the only peptide you have to choose from.
This is from page 1, post #4 (very important on how to use peptides):
There is no increased cortisol release over normal...cortisol is virtually identical to placebo on high dose MK677, notice 219 vs 216 (25mg), and 216 vs 216 on low dose MK677 (12mg) I can cite 2 other studies that state the same.
ReformedNerd said:
On the 5 to 6 months off MK677, I use a blend of 5mg mod grf 1-29 (cjc-1295 no DAC) + 5mg ipamorelin (100 mcg of each) x 3 times a day, 1st thing in morning, pre-workout or pre-cardio on non workout days, and pre-bed
This is my bloodwork after using the blend for 2 weeks, as you can see it took me to the IGF-1 range of better than most 18 year olds. I had the blood drawn at the local lab core approximately 1 hour after my first injection into skin pinch of my abdomen, I inject right under the skin subcutaneously x 3 times a day. Luckily, there was not much of a line of people in the morning, only 2 people in front of me. I go super early.
5mg mod grf 1-29 + 5mg ipamorelin
5000mcg (5mg) per vial
add 2ml bac water in vial
4iu (2 small tics, as each tic = 2iu) on a standard 100iu (1ml) insulin pin gives 100mcg of each
4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each
This is my bloodwork using peptide shots (taken long ago when I first discovered them):
Calculations below using a 3/10 syringe (syringe has 30 total units or tics and vial containing 5mg each of mod
grf 1-29 + 5mg ipamorelin):
A blend of 5mg mod grf 1-29 (same as cjc-1295 no DAC) + 5mg ipamorelin (does not affect cortisol in any way, def the best of the best) used at 100mcg shot (4 tic marks on a 3/10 syringe) x 3 times a day is going to last you 16 days as 5000mcg/300mcg used per day is 16 days. Use 1st thing in morning on empty stomach, pre-workout, and right before bed. If you want increased lubrication for joints while you work out along with greatly increased GH and IGF-1 output, I suggest using the shots or mk677 asap.
Best otc supplement ever used: Take 4 caps of Arachidonic Acid (I like *nhanced athlete) on pre-workout days only (no need to use on off days), pumps are insane and gains are good. Throw in some HMB at 3g x 3 times a day as well, and don't forget the CLA caps, and 3g bcaa's pre-workout or cardio.
x3me said (from page 2 bottom):
Are there oral peptides without those sides?
Tregar here, checking in after a year as usual.
I saw some mis-information one page back, where someone said that mk677 affects cortisol levels. No, mk677 does not affect cortisol levels whatsoever. And if it did, I would never use it, as anything that raises your cortisol levels will also cause you to wake up "too early" every day, etc. That would not be fun. Also, mod grf 1-29 + ipamorelin (peptide shots) also does not affect your cortisol in any way. Definite advantage to either one of these you might choose.
In answer to x3me, No, there are no oral peptides other than mk677. There is absolutely nothing wrong with using shots x 3 times a day, no side effects and works forever without losing potency, just that you need to (1) pre-prepare the shots ahead of time, so that you can take one to work if you are using x 3 times a day, and (2) they are more costly. ** * peptides has one of the best offerings that I have seen over the years. Don't get trapped into thinking mk677 is the only peptide you have to choose from.
This is from page 1, post #4 (very important on how to use peptides):
There is no increased cortisol release over normal...cortisol is virtually identical to placebo on high dose MK677, notice 219 vs 216 (25mg), and 216 vs 216 on low dose MK677 (12mg) I can cite 2 other studies that state the same.
ReformedNerd said:
If you run MK677 for 6 months, then be sure to take off 5 months, then you can use it again, that's the way I've used it for years. If you use it for 8 months, then be sure to take off 5 months as well, then you can start it again, that way always remains 100% effective when you go back on it. Find something else to use on the 5 months off, like peptides or HGH.
On the 5 to 6 months off MK677, I use a blend of 5mg mod grf 1-29 (cjc-1295 no DAC) + 5mg ipamorelin (100 mcg of each) x 3 times a day, 1st thing in morning, pre-workout or pre-cardio on non workout days, and pre-bed
This is my bloodwork after using the blend for 2 weeks, as you can see it took me to the IGF-1 range of better than most 18 year olds. I had the blood drawn at the local lab core approximately 1 hour after my first injection into skin pinch of my abdomen, I inject right under the skin subcutaneously x 3 times a day. Luckily, there was not much of a line of people in the morning, only 2 people in front of me. I go super early.
5mg mod grf 1-29 + 5mg ipamorelin
5000mcg (5mg) per vial
add 2ml bac water in vial
4iu (2 small tics, as each tic = 2iu) on a standard 100iu (1ml) insulin pin gives 100mcg of each
4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each
This is my bloodwork using peptide shots (taken long ago when I first discovered them):
Calculations below using a 3/10 syringe (syringe has 30 total units or tics and vial containing 5mg each of mod
grf 1-29 + 5mg ipamorelin):
A blend of 5mg mod grf 1-29 (same as cjc-1295 no DAC) + 5mg ipamorelin (does not affect cortisol in any way, def the best of the best) used at 100mcg shot (4 tic marks on a 3/10 syringe) x 3 times a day is going to last you 16 days as 5000mcg/300mcg used per day is 16 days. Use 1st thing in morning on empty stomach, pre-workout, and right before bed. If you want increased lubrication for joints while you work out along with greatly increased GH and IGF-1 output, I suggest using the shots or mk677 asap.
Best otc supplement ever used: Take 4 caps of Arachidonic Acid (I like *nhanced athlete) on pre-workout days only (no need to use on off days), pumps are insane and gains are good. Throw in some HMB at 3g x 3 times a day as well, and don't forget the CLA caps, and 3g bcaa's pre-workout or cardio.
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chainsaw
Well-known member
You run a keto diet or low carb diet while on mk677
BCseacow83
Well-known member
Very well. You MAY require more glp so that is a consideration. Reta, sema, and lira all pair well BUT be careful as glps, at least for me, absolutely can be overpowered. For example: on 3mg/day of liraglutide anacyclus xt significantly reduces the drugs effectiveness on appetite reduction, to the point I stopped the anacyclus for now.
BCseacow83
Well-known member
I should add the anacyclus overpowering liraglutide was with anabolic xt in there as well. AXT mildly increases my appetite by itself so factor that in.
Smont
Legend
SLU could help, also.....Berberine, metformin, and/or low to no carb day once a week.
BCseacow83
Well-known member
If not using a glp sure. If running a decent dose of glp BG levels should be decent. I have never has BG issues on mk to begin with. Slu is a great addition none the less.
poison
Board Sponsor
No gkp here, it's the last thing I need haha. Im always down to gain weight, as a, skinny guy who trains hard in bjj and kettkebells, but I eat plenty if good carbs, abd don't want that to become a problem on mk677.
Smont
Legend
If your highly active like that then I wouldn't be too concerned.
Polyethylene glycol?
poison
Board Sponsor
Yeah, polyethylene Glycol, it's the carrier for the science.bio mk677.
Smont
Legend
If your highly active like that then I wouldn't be too concerned.
It's used in the pharmaceutical world and listed as non toxic in small amounts, I believe there's studies saying mildly toxic and bad for gut health but I don't think your going to have issues in the amounts used on a daily basis. I wouldn't be concerned about
BCseacow83
Well-known member
Agreed, berberine or glycophase if one is really concerned.
PolishHamm3r77
Well-known member
I was gonna suggest MA Supps Somatozine but it is out of stock
tregar
Member
MK-677 Ibutamoren Research Powder | Lab Grade Research Chemicals
Sports Technology Labs offers high-quality, third-party tested MK-677 powder (Ibutamoren MK-677) to individuals and institutions engaged in medical research.
sportstechnologylabs.com
2 grams for best price I've seen, have used from them for years, no affiliation at all. Make your own caps cheap.
I use peptides for 6 months of year, then mk677 for other 6 months of year, that way mk677 remains effective forever. peptides are always effective no matter what. 6 months dirt cheap then, 6 months very expensive then (peptides).
I had blood work done at least 9 times on mk677 to measure GH levels, see beginning of this thread, and no it does not affect my blood sure AT ALL, blood sugar always normal, see my bloodwork on page 1 for this. This is because Mk677 will always keep your GH around the levels of a gifted 18 year old, never to extreme, effects always around 4iu of GH, just perfect. Who else do you know that's been using mk677 for many, many, many years like myself? I have lots of experience with this.
Stay away from mk677 if it makes you tired, happens to a percentage of the population, just use peptides instead if it causes you to be tired, NOT worth it, it gives me energy, even euphoria in the beginning, freaking love the stuff, the pumps are incredible when combined with HMB. Kick ass colored happy dreams with great REM sleep, recuperate faster, lift more, better cognition, live like an 18 year old, lol. Hunger pains go away after 2 to 3 weeks, just tough it out, mind over matter LOL.
Like others have said, it feels and works like you are on DIANABOL when you take mk677, no lie.
Take 1st thing in morning, highest GH levels studies show, don't take at night.
My new discovery can be found if you google LSI LSD book
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chainsaw
Well-known member
Are you curious about mk777MK-677 Ibutamoren Research Powder | Lab Grade Research Chemicals
Sports Technology Labs offers high-quality, third-party tested MK-677 powder (Ibutamoren MK-677) to individuals and institutions engaged in medical research.
2 grams for best price I've seen, have used from them for years, no affiliation at all. Make your own caps cheap.
I use peptides for 6 months of year, then mk677 for other 6 months of year, that way mk677 remains effective forever. peptides are always effective no matter what. 6 months dirt cheap then, 6 months very expensive then (peptides).
I had blood work done at least 9 times on mk677 to measure GH levels, see beginning of this thread, and no it does not affect my blood sure AT ALL, blood sugar always normal, see my bloodwork on page 1 for this. This is because Mk677 will always keep your GH around the levels of a gifted 18 year old, never to extreme, effects always around 4iu of GH, just perfect. Who else do you know that's been using mk677 for many, many, many years like myself? I have lots of experience with this.
Stay away from mk677 if it makes you tired, happens to a percentage of the population, just use peptides instead if it causes you to be tired, NOT worth it, it gives me energy, even euphoria in the beginning, freaking love the stuff, the pumps are incredible when combined with HMB. Kick ass colored happy dreams with great REM sleep, recuperate faster, lift more, better cognition, live like an 18 year old, lol. Hunger pains go away after 2 to 3 weeks, just tough it out, mind over matter LOL.
AwakeningAlpha
Active member
Do you like it at night or upon waking?MK-677 Ibutamoren Research Powder | Lab Grade Research Chemicals
Sports Technology Labs offers high-quality, third-party tested MK-677 powder (Ibutamoren MK-677) to individuals and institutions engaged in medical research.
2 grams for best price I've seen, have used from them for years, no affiliation at all. Make your own caps cheap.
I use peptides for 6 months of year, then mk677 for other 6 months of year, that way mk677 remains effective forever. peptides are always effective no matter what. 6 months dirt cheap then, 6 months very expensive then (peptides).
I had blood work done at least 9 times on mk677 to measure GH levels, see beginning of this thread, and no it does not affect my blood sure AT ALL, blood sugar always normal, see my bloodwork on page 1 for this. This is because Mk677 will always keep your GH around the levels of a gifted 18 year old, never to extreme, effects always around 4iu of GH, just perfect. Who else do you know that's been using mk677 for many, many, many years like myself? I have lots of experience with this.
Stay away from mk677 if it makes you tired, happens to a percentage of the population, just use peptides instead if it causes you to be tired, NOT worth it, it gives me energy, even euphoria in the beginning, freaking love the stuff, the pumps are incredible when combined with HMB. Kick ass colored happy dreams with great REM sleep, recuperate faster, lift more, better cognition, live like an 18 year old, lol. Hunger pains go away after 2 to 3 weeks, just tough it out, mind over matter LOL.
tregar
Member
Like others have said, it feels and works like dianabol, no lie. Blood pressure will go up around 11 points on this due to fluid retention just like HGH...if it goes up more than this again avoid mk677 and resort to peptides or stay natural.
1st thing in morning, highest GH levels studies show, not at night, link to study on this page 1 of thread.
1st thing in morning, highest GH levels studies show, not at night, link to study on this page 1 of thread.
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PolishHamm3r77
Well-known member
As long as BP and glucose stay in check. I got zero sides at 12.5mg/day. 25mg/ day yielded elevated BP, elevated glucose, numbness in fingers and hands upon waking, and lethargy
Had to take before bed or I was a sloth all day
PolishHamm3r77
Well-known member
I was taking 1500mg of berberine at 25mg and it wasn’t helping. I was not very lean at the time so that could play into it as well
poison
Board Sponsor
I'm probably around 12%, visible 6 pack and oblique. I'm taking 500mg berberine before breakfast and midday, and will be switching to glucovantage xt, which should be way better. I also take Egcg with the morning dose, agnatine twice a day, chlorella and EDIT:moringa, and other stuff that's actually good for blood sugar. I do 2hrs of bjj 3 times a week, and intense but short kettlebell stuff every off day, so while I'm not testing blood sugar, Im just going to keep assuming I'm fine, and keep going at 12.5mg daily. I feel a lot better on this stuff.
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PolishHamm3r77
Well-known member
You should be fine. Glucose meter w lancet and strips etc is under 20 bucks. Not a bad thing to have.
tregar
Member
Update feb 2026: My fellow weight lifting buddies, I made a ground breaking discovery, I'm a life long chemist and discovered LSI in nature, better than LSD, see my thread here:
I switched from mk677 to a 10mg combo of (5mg cjc 1295 no dac + 5mg ipamorelin) x 3 vials that lasts me 45 days at 3 x 4iu shots a day (pre-bed, pre-workout, and 1st thing in morning on empty stomach). I had my IGF tested 2 hours after morning shot at lab core down the street with on line doctor's order. Only costs me around $3 a day. No side effects Peptide prices have finally come down after all these years due to all the competition.
I tested very high level of 406 ng/ml (from normal baseline 227 ng/ml beginning igf) above what mk677 used to give me (355 ng/ml). Love blueskypeptides, amazing deals with free vials with 2 purchase, and 50% off deals every holiday. https://www.blueskypeptide.com/blend-cjc-1295-no-dac-5mg-with-ipamorelin-5mg.html No affiliation whatsoever, but have noticed they always have some of the best deals of all the peptide places.
This is my bloodwork after using the blend for 2 weeks, as you can see it took me to the IGF-1 range of better than most 18 year olds. I had the blood drawn at the local lab core approximately 2 hour after my first injection into skin pinch of my abdomen, I inject right under the skin subcutaneously x 3 times a day. Luckily, there was not much of a line of people in the morning, only 4 people in front of me. I go super early.
5mg mod grf 1-29 + 5mg ipamorelin
5000mcg (5mg) per vial
add 2ml bac water in vial
4iu (2 small tics, as each tic = 2iu) on a standard 100iu (1ml) insulin pin gives 100mcg of each
4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each
Reconstitute the peptides by adding bacteriostatic water (sterile water with 0.9% benzyl alcohol) avail from amazon or other places.
peptide combo IGF level below:
So the peptides are giving me same levels that 4iu HGH would have given me, and peptides remain effective indefinitely whereas mk677 becomes ineffective at the 6 to 7th month point, at which point you have to stop.
Advantages: no more 100 lb looking bloated face, no more high blood pressure, no more extreme hunger pains, no more of the insane bloating mostly...sticking with peptides the rest of my life. I could not stand the bloated face of mk677 anymore, no side effects at all with the peptides, just super high IGF, and my workouts are bad ass using it, fantastic deep sleep, feel like a million bucks mentally and physically great recuperation for my age of 56, the pumps in gym are insane when peptides combined with HMB and creatine.
p.s. 1gram of Acetyl-L-Carnitine is great to take with or after 1st or 2nd meal on a day off from work, fights depression, remarkable enhancement of colors and mood, my favorite nootropic with zero side effects. People on reddit rave about it, and for good reason. Love to take it before watching a couple movies on day off, I found it a miracle as well as this person:
2026 Book: Home made LSI from HBWR seeds in 3 super simple steps, a more euphoric, colorful, musical LSD
Hello shaman australis, you may remember me as tregar from thenook.org (now defunct cactus & mescaline forum), been long time reader here. A review has popped up of book: USA: LSI, Ancient LSD, Secret of the Eleusis Kykeon and Vedic SOMA: Stahl, Matthew Ray: 9798218881634: Amazon.com: Books A...
www.shaman-australis.com
I switched from mk677 to a 10mg combo of (5mg cjc 1295 no dac + 5mg ipamorelin) x 3 vials that lasts me 45 days at 3 x 4iu shots a day (pre-bed, pre-workout, and 1st thing in morning on empty stomach). I had my IGF tested 2 hours after morning shot at lab core down the street with on line doctor's order. Only costs me around $3 a day. No side effects Peptide prices have finally come down after all these years due to all the competition.
I tested very high level of 406 ng/ml (from normal baseline 227 ng/ml beginning igf) above what mk677 used to give me (355 ng/ml). Love blueskypeptides, amazing deals with free vials with 2 purchase, and 50% off deals every holiday. https://www.blueskypeptide.com/blend-cjc-1295-no-dac-5mg-with-ipamorelin-5mg.html No affiliation whatsoever, but have noticed they always have some of the best deals of all the peptide places.
This is my bloodwork after using the blend for 2 weeks, as you can see it took me to the IGF-1 range of better than most 18 year olds. I had the blood drawn at the local lab core approximately 2 hour after my first injection into skin pinch of my abdomen, I inject right under the skin subcutaneously x 3 times a day. Luckily, there was not much of a line of people in the morning, only 4 people in front of me. I go super early.
5mg mod grf 1-29 + 5mg ipamorelin
5000mcg (5mg) per vial
add 2ml bac water in vial
4iu (2 small tics, as each tic = 2iu) on a standard 100iu (1ml) insulin pin gives 100mcg of each
4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each
Reconstitute the peptides by adding bacteriostatic water (sterile water with 0.9% benzyl alcohol) avail from amazon or other places.
peptide combo IGF level below:
So the peptides are giving me same levels that 4iu HGH would have given me, and peptides remain effective indefinitely whereas mk677 becomes ineffective at the 6 to 7th month point, at which point you have to stop.
Advantages: no more 100 lb looking bloated face, no more high blood pressure, no more extreme hunger pains, no more of the insane bloating mostly...sticking with peptides the rest of my life. I could not stand the bloated face of mk677 anymore, no side effects at all with the peptides, just super high IGF, and my workouts are bad ass using it, fantastic deep sleep, feel like a million bucks mentally and physically great recuperation for my age of 56, the pumps in gym are insane when peptides combined with HMB and creatine.
p.s. 1gram of Acetyl-L-Carnitine is great to take with or after 1st or 2nd meal on a day off from work, fights depression, remarkable enhancement of colors and mood, my favorite nootropic with zero side effects. People on reddit rave about it, and for good reason. Love to take it before watching a couple movies on day off, I found it a miracle as well as this person:
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tregar
Member
Chainsaw said:
www.superiormuscle.com
see post #3 for instance:
I love the peptides better than HGH as it uses my own body's produced IGF and HGH, which is just released "from storage" with the correct signal. With HGH after long time use, it's possible to suppress your body's own natural release of HGH for very long periods (there are studies that show this), seems detrimental to me. I get the same levels as 4iu HGH this way, and I always prefer natural over synthetic, it's in my nature as you can tell from the Australian Shaman forum. 4iu HGH equivalent from the peptide combo is perfect for me. Not to mention the peptide shots when used this way mimic the natural release of igf and HGH over the course of the day, in several large spurts, not one prolonged ultra high level like synthetic HGH which can mess with insulin resistance, glucose, etc. The middle of the day peptide shot can be stored in fridge lunchbox to keep cool. This is all individual and everyone is different, I just always prefer natural. This no side effects peptide combo is very popular right now with anti-aging sites all over the net. Datbtrue is a legend, read all his papers.
Peptides basics by author Datbtrue - The No B.S. Bodybuilding Site
Steroids, GH, PEDs, & Peptides Discussion
www.superiormuscle.com
see post #3 for instance:
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tregar
Member
Ipamorelin only did the trick for me - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community
I was using mod gfr 1-29 and ipamoralin, sadly the sport doctor i had moved from Canada to US in September, i got my last T level check before he left 680 free so no TRT for me. I got prolotherapy and PRP for ligament laxity made worse by an chiropractor and went on mod gfr 1-29 and ipamoralin...
www.excelmale.com
Sermorelin is not very effective due to its very short half life. A better combination is Ipamorelin and MOD GRF 1-29 (CJC 1295 No DAC). You will see greater benefits with that combo. MK677 doesn't do jack squat for fat loss, whereas I have already seen fat loss benefits in abdomen from the peptide combo. With the peptides, there is no bloating, no appetite increase, and no higher blood pressure (all side effects of MK677 as it is derived from GHRP6), and peptides stay effective indefinitely whereas MK677 starts to loose steam at 7th month as all pills eventually loose effectiveness.
Update feb 2026: My fellow weight lifting buddies, I made a ground breaking discovery, I'm a life long chemist and discovered LSI in nature, better than LSD, see my thread here:
2026 Book: Home made LSI from HBWR seeds in 3 super simple steps, a more euphoric, colorful, musical LSD
p.s. 1gram of Acetyl-L-Carnitine is great to take with or after 1st or 2nd meal on a day off from work, fights depression, remarkable enhancement of colors and mood, my favorite nootropic with zero side effects. People on reddit rave about it, and for good reason. Love to take it before watching a couple movies on day off, I found it a miracle as well as this personFrom 227 baseline IGF at my age 56 to 406 ng/ml IGF. 3 shots a day equivalent for me of 4iu HGH, see bloodwork above post #132. Almost double! Even better than my 355 ng/ml reading with 25mg MK677. This 56 year old now has same IGF/HGH as a gifted 16 to 22 year old in the top 2.5% of 16 to 22 year old age group, see graph on post #132, and for only approximately $3 a day.
I take a 100mcg saturation shot x 3 times a day by inserting into a pinched folded skin from abdomen (instructions on post #132), you will feel it working, as after the shot you feel a light flushing sensation 5 to 10 minutes later similar to what niacin feels like & a mood boost can accompany the shot. There is a you tube video on ipamorelin that suggests a 5 on 2 off schedule.
A 5-day-on, 2-day-off (5 on/2 off) schedule is a common approach used for Ipamorelin to aim for optimized growth hormone stimulation while managing potential receptor desensitization. This cycling method is utilized to aim for maintained long-term effectiveness.
MOD GRF 1-29 (CJC 1295 No DAC) + Ipamorelin 5 on / 2 off Schedule Details:
Typical Schedule: Injections are administered for 5 consecutive days, followed by 2 days off (e.g., Monday–Friday, with weekends off).
Cycle Duration: Protocols often involve cycles lasting several weeks or months, followed by a break.
Administration: Subcutaneous (fat layer) injection, frequently in the abdomen, often timed at night.
Purpose of Cycling: This approach is intended to allow for peak activity during the 5 days of stimulation while allowing receptors to reset on weekends, aiming to manage tolerance. Post #132 above explains all.
I prefer to use 3/10 syringes (box of 100 for cheap) to administer the shots. 4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each (MOD GRF 1-29) and (ipamorelin). Zero side effects.
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This is the cycle I follow year round (90 days peptides, then 30 days mk677 at 25mg at night) repeat:
Why You Should Take a Break from GHRH Peptides Like CJC-1295 no DAC and Ipamorelin After 60–90 Days
Why You Should Cycle CJC-1295 and Tesamorelin: The 60–90 Day Protocol
Learn why cycling GHRH peptides like CJC-1295 and Tesamorelin every 60–90 days with a 30-day break is essential. Discover how MK-677 bridges the gap.
revolutionhealth.org
Introducing MK-677: The Bridge Between Cycles
What Is MK-677?
MK-677 (Ibutamoren) is an oral ghrelin mimetic that stimulates GH release by binding to ghrelin receptors. Unlike CJC-1295 or ipamorelin, which work through the GHRH pathway, MK-677 works through the ghrelin pathway, making it an ideal complement.It’s taken orally, which patients often find more convenient than injections.
Benefits of MK-677
- Maintains IGF-1 levels during breaks from GHRH peptides
- Improves sleep architecture and REM sleep
- Enhances muscle retention and recovery
- Supports bone density
- Promotes skin, hair, and nail health
- Increases appetite, which can be beneficial for muscle growth
Why MK-677 Works During Breaks
Because MK-677 stimulates GH release through a different receptor system, it does not contribute to the receptor desensitization seen with GHRH peptides. This means patients can maintain IGF-1 levels while allowing their GHRH receptors to reset.In other words: MK-677 sustains the benefits while your system recovers.
Practical Protocol for Cycling
Here’s the approach I typically recommend in practice:- CJC-1295 no DAC and ipamorelin: Use daily injections for 60–90 days.
- Break Period (30 days): Stop GHRH peptides. Begin MK-677 oral therapy to maintain IGF-1 and ongoing benefits.
- Restart Cycle: After 30 days, resume GHRH peptide therapy. Continue alternating cycles for sustained results.
Again, above is the cycle I follow year round (90 days peptides, then 30 days mk677 at 25mg at night) repeat.
p.s. during the 3 months of peptide use, I use 3 x 100mcg saturation shots of both CJC 1295 no DAC and ipamorelin combo a day (monday thru friday only) with weekends off so the peptides remain effective. You feel a light flushing sensation after injection of peptides using 3/10 syringe (instructions above, look for post with graphs) similar to what niacin feels like, so you will know and feel the peptides are working. I feel absolutely amazing on them daily, can't recommend this continous cycle (3 month peptides then 1 month mk677) highly enough, great muscle gains, amazing sleep and recuperation and pumps are insane in the gym, great cognition, energy and mood, now have the HGH and IGF of an 18 to 22 year old in the top 2.5% of gifted, (see bloodwork and graph in post above this one) and peptides can't be beat for fat loss. 2 weeks into the peptide shots I began experiencing fascinating happy technicolor or colored dreams, which is not normal for me.
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