Hi,
Does Phosphatidic Acid affect ulcerative colitis negatively?
I’ve just taken 1 dose and have had a bad flareup, I googled the 2 and it came up with:
“The phosphatidic acid phosphohydrolase lipin-1 is amplifies inflammation in the gut that mediates colitis and colitis-associated colon cancer development”
Is this the same as the Phos acid I’m taking??
There is no direct research that I'm aware of that shows that it would affect ulcerative colitis negatively.
However, with any autoimmune condition, things can affect us differently.
I'm going to try to explain this the best I can in simple terms:
- When we think of inflammation, we often tend to oversimplify it and not fully understand it. Many think of it as something hurting, rather than an internal process or cascade of events.
- From a scientific perspective, inflammation can be very confusing because some things that can help with inflammation can also contribute to inflammation, depending on what is going on in the body.
- Phosphatidic Acid is a a phospholipid molecule found in cell membranes. It plays a role in various bodily processes, including muscle growth and recovery, due to its interaction with the mTOR pathway.
- However, it is also a precursor for other lipids and can act as a signaling molecule.
So, circling back to autoimmune conditions, in theory supplementing with Phosphatidic Acid should be helpful in many ways and I know for me personally, it helps me with the muscle pain and weakness associated with my flareups.
BUT, it's the precursor and signaling molecule part that can act as kind of a wild card for people with autoimmune conditions - which is why you may find a study showing that PA is helpful with UC but also find a study that shows that it may increase signaling to something that may cause an issue with UC.
I hope that makes sense.
Thank you! For now, I won’t be taking any of it until I hear back from you or
@sns8778
If you decide to try it again, start with 1 capsule per day for 3 days, then 1 capsule twice per day for 3 days, then 2 and 1 for 3 days, then 2 and 2.
Ok so the evidence isn’t strong. There is little to no evidence directly linking phosphatidic acid to inflammation. But the evidence you brought up is from another phospholipid related to phosphatidic acid, not actual phosphatidic acid, they aren’t the same.
From what I could find in some cases phosphatidic acid can increase some inflammatory markers but there’s also some studies linking it or its derivatives to anti colitis and gut healing effects.
I think what you should do is:
-If you are on any DMARDs for your autoimmune problems, keep taking them since they will treat it directly.
-I wouldn’t worry too much about PA causing inflammation
-I would keep a log or journal of your symptoms and once you start taking PA again see if they get worse.
It’s most likely nothing to worry about, you just have to listen to your own body. But Steve knows more about this than me so I would trust his judgement over mine. Lmk if you have more questions.
Good insight. I think that from an evidence standpoint, it shouldn't cause an issue and may even help with consistent use.
Hi,
Thanks for the details response I really appreciate it.
I’ll wait for Steve to chime in too for peace of mind.
I'm sorry for the delayed reply. I hadn't gotten on here since Thursday.
I have crohn's disease and I can't handle phosphatidic acid, I don't know if the different forms of IBD share the same triggers or not. Sadly there seems to be a lot of stuff that I would really like to run but find it causes flares each time I try it. It's a bit of a gamble each time I try a new product and sometimes stuff that I really wouldn't expect to cause a flare does, despite all information about it saying it should lower inflammation etc. I often try to push through to see if my body will adjust and occasionally it does but lately I've come to the realization it's probably a lot more beneficial to being able to stay consistent in workouts than the benefit the supplement may give if it's causing problems.
I was replying to these from bottom to top and in the post below, I had just written about how some things can cause temporary issues even when studies show longer term positive outcomes - which actually ties in with what you wrote here about some things causing flareups that are supposed to reduce inflammation. It's a very in depth but fascinating context to that, but is far too in depth to write in a post. It's on my list of articles to write if I can ever find a way to have more hours in the day though.
I’m the same as you to be fair, it’s all trial and error.
I also read the study saying Phos Acid is good for ulcerative colitis but there’s a lot of mixed information out there.
I’m just a bit bummed cos I really thought it would be good but I’m a bit apprehensive about trying another dose….
I know of several people that use Phosphatidic Acid XT with UC and it doesn't bother them, but everyone is different when it comes to autoimmune conditions.
You're right - there is definitely a lot of conflicting information out there - and I think that some of it is because of individual response to things.
Also, when it comes to saying that something is good for something, if we're talking about in a healing and repair sense, sometimes symptoms get worse before they get better. I would never tell anyone with an autoimmune condition to use something causing a flareup, but I mean from a scientific perspective, sometimes studies are measuring longer term outcomes by blood markers, not short term symptoms.
I have an autoimmune disorder and i cant take Phosphatidic acid too, before i get the disease i have used it without any problem but not now.
I dont have any problems with Prine and i get the same results in strenght that i had with Phosphatidic before, so maybe is a good time to try it.
That's a good suggestion, and good insight.
Autoimmune conditions are so unpredictable in how they can affect us all individually.
I saw that it was clarified, but Prime XT. I've never heard of it bothering anyone with any autoimmune condition.
I got IBS and PA treats me well
I even love doubling up the dose sometimes lol
My autoimmune condition is an inflammatory condition and causes a lot of stomach issues as well, and I've found the same as you - it doesn't bother my stomach and I've doubled the dose a lot too. It actually helps the aspect of my condition where the flareups can cause a lot of muscle weakness.
Optimize-T, Alpha One (but start off with one and then increase to two as your body adjusts and avoid taking it with spicy food), Anacyclus, Prime XT, Anabolic XT, Creatine HCL, for some reason I can’t tolerate Anabolic Effect it sets my bowels off but when I was taking it I liked the muscle building effect on it, I might give it a shot again once things are settled and start off slow.
All the products Steve brings out are high quality. If you look at another post of mine I had people asking me if I was on roids lol, I certainly am not and have never tried any.
Thank you for the kind words. I'm glad that you enjoy the products.
A tip on Anabolic Effect - its rare for it to bother someone's stomach, but for anyone that does, start out at 2 caps twice once per day for a day or two, then 2 caps twice per day for a couple days, then 2 caps 3x per day. Then, most people can shift to 3 caps twice per day if they want to.
Yeah it all seems to vary so much person to person from what I've seen and you pretty much just have to figure out yourself what your body can handle. It would be nice if there was an authoritative list or something but sadly not
There could never be a truthful authoritative list of things that people with autoimmune conditions can or cannot take because it can vary by the person.
I have an autoimmune condition and also have the non-celiac gluten sensitivity, which is a condition where the body shows an immune response different and distinct from celiac disease. There are supplements, foods, and lifestyle factors that cause flareups and issues for me that may not others, and there are some that cause issues for others that don't for me, and some that I've even found helpful.
