tregar
Member
This is part 2 of the giant mk677 theoretical research thread.
Update feb 2026: My fellow weight lifting buddies, I made a ground breaking discovery, I'm a life long chemist and discovered LSI in nature, better than LSD, see my thread here:
www.bluelight.org
Update 2026: I switched from mk677 to a 10mg combo of (5mg cjc 1295 no dac + 5mg ipamorelin) x 3 vials that lasts me 45 days at 3 x 4iu shots a day (pre-bed, pre-workout, and 1st thing in morning on empty stomach). I had my IGF tested 2 hours after morning shot at lab core down the street with on line doctor's order. Only costs me around $3 a day. No side effects Peptide prices have finally come down after all these years due to all the competition.
From 227 baseline IGF at my age 56 to 406 ng/ml IGF. 3 shots a day equivalent for me of 4iu HGH, see bloodwork below. Almost double! Even better than my 355 ng/ml reading with 25mg MK677. This 56 year old now has same IGF/HGH as a gifted 16 to 22 year old in the top 2.5% of 16 to 22 year old age group, see graph below, and for only approximately $3 a day.
I tested very high level of 406 ng/ml (from normal baseline 227 ng/ml igf) above what mk677 used to give me (355 ng/ml). Love blueskypeptides, amazing deals with free vials with 2 purchase, and 50% off deals every holiday. https://www.blueskypeptide.com/blend-cjc-1295-no-dac-5mg-with-ipamorelin-5mg.html No affiliation whatsoever, but have noticed they always have some of the best deals of all the peptide places.
This is my bloodwork after using the blend for 2 weeks, as you can see it took me to the IGF-1 range of better than most 18 year olds. I had the blood drawn at the local lab core approximately 2 hour after my first injection into skin pinch of my abdomen, I inject right under the skin subcutaneously x 3 times a day. Luckily, there was not much of a line of people in the morning, only 4 people in front of me. I go super early.
5mg mod grf 1-29 + 5mg ipamorelin
5000mcg (5mg) per vial
add 2ml bac water in vial
4iu (2 small tics, as each tic = 2iu) on a standard 100iu (1ml) insulin pin gives 100mcg of each
4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each
Reconstitute the peptides by adding bacteriostatic water (sterile water with 0.9% benzyl alcohol) avail from amazon or other places.
peptide combo IGF level below:
So the peptides are giving me same levels that 4iu HGH would have given me, and peptides remain effective indefinitely whereas mk677 becomes ineffective at the 6 to 7th month point, at which point you have to stop.
Advantages: no more 100 lb looking bloated face, no more high blood pressure, no more extreme hunger pains, no more of the insane bloating mostly...sticking with peptides the rest of my life. I could not stand the bloated face of mk677 anymore, no side effects at all with the peptides, just super high IGF, and my workouts are bad ass using it, fantastic deep sleep, feel like a million bucks mentally and physically, great recuperation for my age of 56, the pumps in gym are insane when peptides combined with HMB and creatine.
p.s. 1gram of Acetyl-L-Carnitine is great to take with or after 1st or 2nd meal on a day off from work, fights depression, remarkable enhancement of colors and mood, my favorite nootropic with zero side effects. People on reddit rave about it, and for good reason. Love to take it before watching a couple movies on day off, I found it a miracle as well as this person:
https://www.reddit.com/r/cfs/comments/110i601/acetyllcarnitine_did_a_miracle_for_me_it_might
Chainsaw said:
https://www.superiormuscle.com/foru...oids/44261-peptides-basics-by-author-datbtrue
see post #3 for instance:
Sermorelin is not very effective due to its very short half life. A better combination is Ipamorelin and MOD GRF 1-29 (CJC 1295 No DAC). You will see greater benefits with that combo. MK677 doesn't do jack squat for fat loss, whereas I have already seen fat loss benefits in abdomen from the peptide combo. With the peptides, there is no bloating, no appetite increase, and no higher blood pressure (all side effects of MK677 as it is derived from GHRP6), and peptides stay effective indefinitely whereas MK677 starts to loose steam at 7th month as all pills eventually loose effectiveness.
I take a 100mcg saturation shot x 3 times a day by inserting into a pinched folded skin from abdomen (instructions on post #132), you will feel it working, as after the shot you feel a light flushing sensation 5 to 10 minutes later similar to what niacin feels like & a mood boost can accompany the shot. There is a you tube video on ipamorelin that suggests a 5 on 2 off schedule.
A 5-day-on, 2-day-off (5 on/2 off) schedule is a common approach used for Ipamorelin to aim for optimized growth hormone stimulation while managing potential receptor desensitization. This cycling method is utilized to aim for maintained long-term effectiveness.
MOD GRF 1-29 (CJC 1295 No DAC) + Ipamorelin 5 on / 2 off Schedule Details:
Typical Schedule: Injections are administered for 5 consecutive days, followed by 2 days off (e.g., Monday–Friday, with weekends off).
Cycle Duration: Protocols often involve cycles lasting several weeks or months, followed by a break.
Administration: Subcutaneous (fat layer) injection, frequently in the abdomen, often timed at night.
Purpose of Cycling: This approach is intended to allow for peak activity during the 5 days of stimulation while allowing receptors to reset on weekends, aiming to manage tolerance. Post #132 above explains all.
I prefer to use 3/10 syringes (box of 100 for cheap) to administer the shots. 4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each (MOD GRF 1-29) and (ipamorelin). Zero side effects.
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This is the cycle I follow year round (90 days peptides, then 30 days mk677 at 25mg at night) repeat:
revolutionhealth.org
MK-677 (Ibutamoren) is an oral ghrelin mimetic that stimulates GH release by binding to ghrelin receptors. Unlike CJC-1295 or Tesamorelin, which work through the GHRH pathway, MK-677 works through the ghrelin pathway, making it an ideal complement.
It’s taken orally, which patients often find more convenient than injections.
Because MK-677 stimulates GH release through a different receptor system, it does not contribute to the receptor desensitization seen with GHRH peptides. This means patients can maintain IGF-1 levels while allowing their GHRH receptors to reset.
In other words: MK-677 sustains the benefits while your system recovers.
Here’s the approach I typically recommend in practice:
Again, above is the cycle I follow year round (90 days peptides, then 30 days mk677 at 25mg at night) repeat.
p.s. during the 3 months of peptide use, I use 3 x 100mcg saturation shots of both CJC 1295 no DAC and ipamorelin combo a day (monday thru friday only) with weekends off so the peptides remain effective. You feel a light flushing sensation after injection of peptides using 3/10 syringe (instructions above, look for post with graphs) similar to what niacin feels like, so you will know and feel the peptides are working. I feel absolutely amazing on them daily, can't recommend this continous cycle (3 month peptides then 1 month mk677) highly enough, great muscle gains, amazing sleep and recuperation and pumps are insane in the gym, great cognition, energy and mood, now have the HGH and IGF of an 18 to 22 year old in the top 2.5% of gifted, (see bloodwork and graph above) and peptides can't be beat for fat loss. 2 weeks into the peptide shots I began experiencing fascinating happy technicolor or colored dreams, which is not normal for me.
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This is 2022 part II of the giant part I (50,000 view) 2018 MK677 thread:
Invalid Link Removed
Please post here! Give us your experiences.
Smont said:
1) Smont is correct in that it will not help you loose fat like HGH, BUT it has just as great if not greater nitrogen retention as 4iu of HGH, you can fast for long periods like I do (I eat in an 8 hour window, on a keto diet, and fast from 3pm till 7am next morning with cardio during the fast to maintain my 220lbs at 12% body fat), and never loose any muscle...just keeps piling on week after week). I also notice a 25 to 35% increase in strength over the many months I use it, compared to placebo, or the months I have not used it at all (no mk677, no peptides, nada). The studies on older folks also showed a 25% increase in strength in all leg press exercises in those who used it as well as compared to non-users.
I actually went back on the mk677 at 25mg several days ago, gonna use for at least 6 months (July 2022 till end of January 2023)....will go back on the peptides after a long 6 month mk677 run.
I alternate the two every 6 months so the mk677 stays 100% effective, go on the peptides for 6 months, then back on mk677...mk677 never loses any effectiveness this way. The peptides I use (100mcg mod grf 1-29 + 100mcg ipamorelin) x 3 times a day never loose effectiveness. I take one shot in morning, one before or after workout (before cardio on non workout days) and one shot before bed. Peptides can be used for life and never loose any effectiveness as this combo is NOT a derivative of GHRP-6. MK677 is dirt cheap compared to the peptides (around 120 a month for x 3 times a day for 30 days, and gives me very similar levels to the mk677)...I always save big time money on the 6 months I am on MK677 compared to the peptides.
mase 1 said:
Benefits of MK677 I've noticed:
1) releases your own natural stored up HGH in your brain that you still make plenty of when you are older, but due to the body programming the body for death as you get older, it does not release these huge stored up amounts anymore...MK677 puts the breaks on somatostatin so that these youthful levels of HGH can be released. Unlike HGH, MK677 is way less expensive, and you never have to worry about your body's natural production of HGH being shut down or diminished for very long periods of time which has been shown to happen if you take HGH daily for year or more straight. Even the brain's natural production of HGH has been shown to NOT HAPPEN if you take HGH during morning hours, studies show the night time HGH pulses are still suppressed.
2) great nootropic effect on the brain = improved mood
3) great sleep with longer time in REM sleep, better muscle building during sleep
4) better energy all day.
5) Skin looks younger due to greater collagen production
6) recover quicker from workouts, injuries and minor cuts
6) increased lubrication of joints in gym due to same collagen increase
7) nails and hair grow very fast. No lethargy at all for me, zero.
8) truly do feel like an 18 year old on it. Best nootropic imho.
I'm on a year round keto diet, so the water retention in the face is very minimal, and goes away completely along with the minor hunger pains after 2 to 3 weeks. Then it's smooth sailing. Mk677 sends my igf-1 from 225 to 370 or so igf-1.
Daily 25mg takes me to the HGH output of a gifted 18 year old.
Update: 2 days after being on 25mg a day mk677, feel great! crystal clear clarity in the brain, zero brain fog, feel great pump all day, increased endurance in gym and cardio on off day, really great mood, mega pumps during workout, great sleep, love the stuff! Will use from June 23, 2022 till end of December 2022 (6 months).
----------------------------------------------
25mg MK677 bloodwork FAQ = 4iu pharm grade HGH (used 25mg mk677 for 6 months out of the year for 5 years straight with 7 bloodworks)
Year 2018:
----------
pic 1) 4-6-2018, baseline igf -1 = 227 ng/ml------------------------------------------baseline [227, high] (age 48, ref is 67 to 205 ng/mL)
pic 2) 4-11-2018, 2 days on 4iu of Chinese pharm grade gh = 380 ng/ml----increase of 153 points
washout period of 2 weeks off HGH
pic 3) 4-25-2018, 2 weeks on mk677 only = 372 ng/ml----------------------------increase of 145 points
pic 4) 9-7-2018, 6 months on mk677 only = 322 ng/ml----------------------------increase of 95 points
pic 5) 11-2-18, 8 months on mk677 only = 304 ng/ml--------------------------------------increase of 75 points
Start of new year 2019:
------------------------
pic 6) 3-18-19, 4 weeks on mk677 only = 327 ng/ml-------------------------------------increase of 100 points, (2-22-19 thru 3-18-19)
Start of new year 2020:
-------------------------
pic 7) 2-3-2020, 2nd baseline igf-1 reading = 229 ng/ml-----------------------------------baseline [229, high] (age 50, ref is 67 to 205 ng/ml)
Notice how using MK677 for many years, did nothing to hurt my normal IGF-1, it read completely normal when I came off it for several weeks.
372 ng/ml igf-1 is equivalent to 4.0 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (2 weeks)
322 ng/ml igf-1 is equivalent to 3.4 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (6 months)
304 ng/ml igf-1 is equivalent of 3.2 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (8 months)
327 ng/ml igf-1 is equivalent of 3.5 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (4 weeks)
So, in conclusion, being on mk677 for 2 weeks is similar to being on 4iu of Chinese pharm grade GH, for me anyhow, as the bloodtest proves it. Being on mk677 for 6 months is similar to being on 3.4iu of Chinese pharm grade GH. The Chinese pharm grade HGH I used was Supertropin (used in China to treat dwarfism).
This is an incredible raise in igf-1 for my current age of 52 as reference is 67-205 for my age group, and the mk677 for 2 weeks brought me beyond the high range for a young adult in their early 20's.
I couldn't be happier, this helps explain the increases in strength at the gym, as well as the fast recovery from workouts. Cardio on off days is a breeze. Not to mention mega pumps in the gym, a feeling of fullness all day in muscles, nootropic effects on brain of improved mood for me, enhanced energy all day, great sleep, zero lethargy for me everyday using it (I'm lucky in that aspect). I've even had rare days of less sleep due to schedule, and I still felt like a million bucks the next day being on mk677 as it gives you such great sleep with pleasant enhanced dreams many nights. As I am on a keto diet year round, there is minimal water retention in the face, both the minimal retention of water in face and hunger pains die down to zero after around 2 weeks on it, then it is smooth sailing.
I've continued to take bloodwork every few months, and this 372 igf-1 then falls to around 325 igf-1 (equivalent to 3.4iu HGH) for the rest of the 8 months, still remaining at 325 by the 7 month, when it starts to fall slightly to 300 around month 8, but I get off after 6 months, as that is how long it remains 100% effective without dipping at all from the peak (6 to 7 months it reamains 100% effective). I've taken blookwork every 1 of the 4 years I have used it....my baseline was at 225 the 2nd year I took it (after being off mk677 for several weeks)...it once again took me to the exact same high levels of 4iu pharm grade HGH year after year, each of the 4 years, remains 100% effective year after year, and your baseline never changes from normal.
--> The reason for the fall from 372 to 325 igf-1 is due to a "feedback loop" the body puts in place after being on mk677 for 3 weeks, in order to keep the levels from raising to high, the body will only maintain it at the HGH of around an 18 year old max.
My only concern is that maybe around 25% of people (like myself) never experience any lethargy on MK67, zero lethargy...however from the reviews I have read the other 75% of people do experience lethargy on it, in which case I would recommend NOT using it, it's just not worth it if it makes you tired. Find something else to use like peptides or HGH then.
MK677 should bring you to the high level of a young adult if you are already at the high end for an older adult.
Older folks (59-225ug/L)
young adult (116-358 ug/L)
My new discovery can be found if you google LSI LSD book
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Update feb 2026: My fellow weight lifting buddies, I made a ground breaking discovery, I'm a life long chemist and discovered LSI in nature, better than LSD, see my thread here:
Lysergamides - LSI, Ancient LSD, Secret of the Eleusis Kykeon and Vedic SOMA
This is something you don't want to miss out on, even better than LSD imho, more colorful, more euphoric, no anxiety, and more music enhancing, just as visual as LSD with hours of closed eye colored visions...the 2 stirring steps in chapter 5 can be reduced down from 20 minutes down to 10...
Update 2026: I switched from mk677 to a 10mg combo of (5mg cjc 1295 no dac + 5mg ipamorelin) x 3 vials that lasts me 45 days at 3 x 4iu shots a day (pre-bed, pre-workout, and 1st thing in morning on empty stomach). I had my IGF tested 2 hours after morning shot at lab core down the street with on line doctor's order. Only costs me around $3 a day. No side effects Peptide prices have finally come down after all these years due to all the competition.
From 227 baseline IGF at my age 56 to 406 ng/ml IGF. 3 shots a day equivalent for me of 4iu HGH, see bloodwork below. Almost double! Even better than my 355 ng/ml reading with 25mg MK677. This 56 year old now has same IGF/HGH as a gifted 16 to 22 year old in the top 2.5% of 16 to 22 year old age group, see graph below, and for only approximately $3 a day.
I tested very high level of 406 ng/ml (from normal baseline 227 ng/ml igf) above what mk677 used to give me (355 ng/ml). Love blueskypeptides, amazing deals with free vials with 2 purchase, and 50% off deals every holiday. https://www.blueskypeptide.com/blend-cjc-1295-no-dac-5mg-with-ipamorelin-5mg.html No affiliation whatsoever, but have noticed they always have some of the best deals of all the peptide places.
This is my bloodwork after using the blend for 2 weeks, as you can see it took me to the IGF-1 range of better than most 18 year olds. I had the blood drawn at the local lab core approximately 2 hour after my first injection into skin pinch of my abdomen, I inject right under the skin subcutaneously x 3 times a day. Luckily, there was not much of a line of people in the morning, only 4 people in front of me. I go super early.
5mg mod grf 1-29 + 5mg ipamorelin
5000mcg (5mg) per vial
add 2ml bac water in vial
4iu (2 small tics, as each tic = 2iu) on a standard 100iu (1ml) insulin pin gives 100mcg of each
4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each
Reconstitute the peptides by adding bacteriostatic water (sterile water with 0.9% benzyl alcohol) avail from amazon or other places.
peptide combo IGF level below:
So the peptides are giving me same levels that 4iu HGH would have given me, and peptides remain effective indefinitely whereas mk677 becomes ineffective at the 6 to 7th month point, at which point you have to stop.
Advantages: no more 100 lb looking bloated face, no more high blood pressure, no more extreme hunger pains, no more of the insane bloating mostly...sticking with peptides the rest of my life. I could not stand the bloated face of mk677 anymore, no side effects at all with the peptides, just super high IGF, and my workouts are bad ass using it, fantastic deep sleep, feel like a million bucks mentally and physically, great recuperation for my age of 56, the pumps in gym are insane when peptides combined with HMB and creatine.
p.s. 1gram of Acetyl-L-Carnitine is great to take with or after 1st or 2nd meal on a day off from work, fights depression, remarkable enhancement of colors and mood, my favorite nootropic with zero side effects. People on reddit rave about it, and for good reason. Love to take it before watching a couple movies on day off, I found it a miracle as well as this person:
https://www.reddit.com/r/cfs/comments/110i601/acetyllcarnitine_did_a_miracle_for_me_it_might
Chainsaw said:
I love the peptides better than HGH as it uses my own body's produced IGF and HGH, which is just released "from storage" with the correct signal. With HGH after long time use, it's possible to suppress your body's own natural release of HGH for very long periods (there are studies that show this), seems detrimental to me. I get the same levels as 4iu HGH this way, and I always prefer natural over synthetic, it's in my nature as you can tell from the Australian Shaman forum. 4iu HGH equivalent from the peptide combo is perfect for me. Not to mention the peptide shots when used this way mimic the natural release of igf and HGH over the course of the day, in several large spurts, not one prolonged ultra high level like synthetic HGH which can mess with insulin resistance, glucose, etc. The middle of the day peptide shot can be stored in fridge lunchbox to keep cool. This is all individual and everyone is different, I just always prefer natural. This no side effects peptide combo is very popular right now with anti-aging sites all over the net. Datbtrue is a legend, read all his papers.I actually was going to message you and see if you were going to research MK 777, as they say it has less side effects compared to MK677.
So if these 2 peptides bring your IGF levels this high, why dont you just swith over to regular HGH, for most part HGH is very cheap now even in some cases cheaper than peptides.
https://www.superiormuscle.com/foru...oids/44261-peptides-basics-by-author-datbtrue
see post #3 for instance:
For instance a lady who is about 65 uses a tiny amount of the peptide combo pre-bed (25mcg of each). She was crippled with bone pain and had to crawl up stairs. Prescription GH was of limited effect. The no side effect mod GRF(1-29)/ipamorelin changed her life immediately. Now 6 months later she walks 2 miles a day and even breaks into a jog when pushing the grandkids stroller. Her doctor says her bone density is that of a young person. This is just an illustration... and for bodybuilding her dosing is not sufficient...
Sermorelin is not very effective due to its very short half life. A better combination is Ipamorelin and MOD GRF 1-29 (CJC 1295 No DAC). You will see greater benefits with that combo. MK677 doesn't do jack squat for fat loss, whereas I have already seen fat loss benefits in abdomen from the peptide combo. With the peptides, there is no bloating, no appetite increase, and no higher blood pressure (all side effects of MK677 as it is derived from GHRP6), and peptides stay effective indefinitely whereas MK677 starts to loose steam at 7th month as all pills eventually loose effectiveness.
I take a 100mcg saturation shot x 3 times a day by inserting into a pinched folded skin from abdomen (instructions on post #132), you will feel it working, as after the shot you feel a light flushing sensation 5 to 10 minutes later similar to what niacin feels like & a mood boost can accompany the shot. There is a you tube video on ipamorelin that suggests a 5 on 2 off schedule.
A 5-day-on, 2-day-off (5 on/2 off) schedule is a common approach used for Ipamorelin to aim for optimized growth hormone stimulation while managing potential receptor desensitization. This cycling method is utilized to aim for maintained long-term effectiveness.
MOD GRF 1-29 (CJC 1295 No DAC) + Ipamorelin 5 on / 2 off Schedule Details:
Typical Schedule: Injections are administered for 5 consecutive days, followed by 2 days off (e.g., Monday–Friday, with weekends off).
Cycle Duration: Protocols often involve cycles lasting several weeks or months, followed by a break.
Administration: Subcutaneous (fat layer) injection, frequently in the abdomen, often timed at night.
Purpose of Cycling: This approach is intended to allow for peak activity during the 5 days of stimulation while allowing receptors to reset on weekends, aiming to manage tolerance. Post #132 above explains all.
I prefer to use 3/10 syringes (box of 100 for cheap) to administer the shots. 4iu (4 small tics, as each tic = 1iu) on a 3/10 syringe insulin pin gives 100mcg of each (MOD GRF 1-29) and (ipamorelin). Zero side effects.
-------------------------------------------------------------------------------------------------------------------
This is the cycle I follow year round (90 days peptides, then 30 days mk677 at 25mg at night) repeat:
Why You Should Cycle CJC-1295 and Tesamorelin: The 60–90 Day Protocol
Learn why cycling GHRH peptides like CJC-1295 and Ipamorelin every 60–90 days with a 30-day break is essential. Discover how MK-677 bridges the gap.MK-677 (Ibutamoren) is an oral ghrelin mimetic that stimulates GH release by binding to ghrelin receptors. Unlike CJC-1295 or Tesamorelin, which work through the GHRH pathway, MK-677 works through the ghrelin pathway, making it an ideal complement.
It’s taken orally, which patients often find more convenient than injections.
- Maintains IGF-1 levels during breaks from GHRH peptides
- Improves sleep architecture and REM sleep
- Enhances muscle retention and recovery
- Supports bone density
- Promotes skin, hair, and nail health
- Increases appetite, which can be beneficial for muscle growth
Because MK-677 stimulates GH release through a different receptor system, it does not contribute to the receptor desensitization seen with GHRH peptides. This means patients can maintain IGF-1 levels while allowing their GHRH receptors to reset.
In other words: MK-677 sustains the benefits while your system recovers.
Here’s the approach I typically recommend in practice:
- CJC-1295 no DAC and ipamorelin: Use daily injections for 60–90 days.
- Break Period (30 days): Stop GHRH peptides. Begin MK-677 oral therapy to maintain IGF-1 and ongoing benefits.
- Restart Cycle: After 30 days, resume GHRH peptide therapy. Continue alternating cycles for sustained results.
Again, above is the cycle I follow year round (90 days peptides, then 30 days mk677 at 25mg at night) repeat.
p.s. during the 3 months of peptide use, I use 3 x 100mcg saturation shots of both CJC 1295 no DAC and ipamorelin combo a day (monday thru friday only) with weekends off so the peptides remain effective. You feel a light flushing sensation after injection of peptides using 3/10 syringe (instructions above, look for post with graphs) similar to what niacin feels like, so you will know and feel the peptides are working. I feel absolutely amazing on them daily, can't recommend this continous cycle (3 month peptides then 1 month mk677) highly enough, great muscle gains, amazing sleep and recuperation and pumps are insane in the gym, great cognition, energy and mood, now have the HGH and IGF of an 18 to 22 year old in the top 2.5% of gifted, (see bloodwork and graph above) and peptides can't be beat for fat loss. 2 weeks into the peptide shots I began experiencing fascinating happy technicolor or colored dreams, which is not normal for me.
------------------------------------------------------------------------------------------------------------------
This is 2022 part II of the giant part I (50,000 view) 2018 MK677 thread:
Invalid Link Removed
Please post here! Give us your experiences.
Smont said:
I've taken 25mg MK66 powder in morning with coffee for 6 months out of the year, for 5 years now, and I've taken at least 7 blood works over the years (cost me nothing as it goes on my pre-loaded $1800 medical card), MK677 is highly effective for 8 months, when it then starts to dip a bit from the peak, it only looses slight effectiveness at that point as it is a derivative of GHRP-6. At that point (6 months, a little bit sooner than 8 months) is when I go off. I will then switch to peptides (remain effective indefinitely, but expensive) at that point for the next 6 months.There is no amount of mk that will make it comparable to gh because they don't do the same thing. They have a few things in common but more things that make them completely different.
1) Smont is correct in that it will not help you loose fat like HGH, BUT it has just as great if not greater nitrogen retention as 4iu of HGH, you can fast for long periods like I do (I eat in an 8 hour window, on a keto diet, and fast from 3pm till 7am next morning with cardio during the fast to maintain my 220lbs at 12% body fat), and never loose any muscle...just keeps piling on week after week). I also notice a 25 to 35% increase in strength over the many months I use it, compared to placebo, or the months I have not used it at all (no mk677, no peptides, nada). The studies on older folks also showed a 25% increase in strength in all leg press exercises in those who used it as well as compared to non-users.
I actually went back on the mk677 at 25mg several days ago, gonna use for at least 6 months (July 2022 till end of January 2023)....will go back on the peptides after a long 6 month mk677 run.
I alternate the two every 6 months so the mk677 stays 100% effective, go on the peptides for 6 months, then back on mk677...mk677 never loses any effectiveness this way. The peptides I use (100mcg mod grf 1-29 + 100mcg ipamorelin) x 3 times a day never loose effectiveness. I take one shot in morning, one before or after workout (before cardio on non workout days) and one shot before bed. Peptides can be used for life and never loose any effectiveness as this combo is NOT a derivative of GHRP-6. MK677 is dirt cheap compared to the peptides (around 120 a month for x 3 times a day for 30 days, and gives me very similar levels to the mk677)...I always save big time money on the 6 months I am on MK677 compared to the peptides.
mase 1 said:
Yes, there is muscle fullness on the peptides, but the fullness on mk677 is even greater, like a dianabol feeling, super great nitrogen retention too. Really great mk677 pumps, very full indeed. The mk677 gives me the HGH of 4.0iu, I've done bloodwork on both mk677 and 4iu of pharm grade HGH, both the same.I notice great muscle fullness on mk677. Do you notice a difference with ghrp/ipamorelin in regards to comparing muscle fullness?
Benefits of MK677 I've noticed:
1) releases your own natural stored up HGH in your brain that you still make plenty of when you are older, but due to the body programming the body for death as you get older, it does not release these huge stored up amounts anymore...MK677 puts the breaks on somatostatin so that these youthful levels of HGH can be released. Unlike HGH, MK677 is way less expensive, and you never have to worry about your body's natural production of HGH being shut down or diminished for very long periods of time which has been shown to happen if you take HGH daily for year or more straight. Even the brain's natural production of HGH has been shown to NOT HAPPEN if you take HGH during morning hours, studies show the night time HGH pulses are still suppressed.
2) great nootropic effect on the brain = improved mood
3) great sleep with longer time in REM sleep, better muscle building during sleep
4) better energy all day.
5) Skin looks younger due to greater collagen production
6) recover quicker from workouts, injuries and minor cuts
6) increased lubrication of joints in gym due to same collagen increase
7) nails and hair grow very fast. No lethargy at all for me, zero.
8) truly do feel like an 18 year old on it. Best nootropic imho.
I'm on a year round keto diet, so the water retention in the face is very minimal, and goes away completely along with the minor hunger pains after 2 to 3 weeks. Then it's smooth sailing. Mk677 sends my igf-1 from 225 to 370 or so igf-1.
Daily 25mg takes me to the HGH output of a gifted 18 year old.
Update: 2 days after being on 25mg a day mk677, feel great! crystal clear clarity in the brain, zero brain fog, feel great pump all day, increased endurance in gym and cardio on off day, really great mood, mega pumps during workout, great sleep, love the stuff! Will use from June 23, 2022 till end of December 2022 (6 months).
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25mg MK677 bloodwork FAQ = 4iu pharm grade HGH (used 25mg mk677 for 6 months out of the year for 5 years straight with 7 bloodworks)
Year 2018:
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pic 1) 4-6-2018, baseline igf -1 = 227 ng/ml------------------------------------------baseline [227, high] (age 48, ref is 67 to 205 ng/mL)
pic 2) 4-11-2018, 2 days on 4iu of Chinese pharm grade gh = 380 ng/ml----increase of 153 points
washout period of 2 weeks off HGH
pic 3) 4-25-2018, 2 weeks on mk677 only = 372 ng/ml----------------------------increase of 145 points
pic 4) 9-7-2018, 6 months on mk677 only = 322 ng/ml----------------------------increase of 95 points
pic 5) 11-2-18, 8 months on mk677 only = 304 ng/ml--------------------------------------increase of 75 points
Start of new year 2019:
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pic 6) 3-18-19, 4 weeks on mk677 only = 327 ng/ml-------------------------------------increase of 100 points, (2-22-19 thru 3-18-19)
Start of new year 2020:
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pic 7) 2-3-2020, 2nd baseline igf-1 reading = 229 ng/ml-----------------------------------baseline [229, high] (age 50, ref is 67 to 205 ng/ml)
Notice how using MK677 for many years, did nothing to hurt my normal IGF-1, it read completely normal when I came off it for several weeks.
372 ng/ml igf-1 is equivalent to 4.0 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (2 weeks)
322 ng/ml igf-1 is equivalent to 3.4 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (6 months)
304 ng/ml igf-1 is equivalent of 3.2 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (8 months)
327 ng/ml igf-1 is equivalent of 3.5 iu pharm grade GH from China, as 95 point raise per each 1iu of hgh for me (4 weeks)
So, in conclusion, being on mk677 for 2 weeks is similar to being on 4iu of Chinese pharm grade GH, for me anyhow, as the bloodtest proves it. Being on mk677 for 6 months is similar to being on 3.4iu of Chinese pharm grade GH. The Chinese pharm grade HGH I used was Supertropin (used in China to treat dwarfism).
This is an incredible raise in igf-1 for my current age of 52 as reference is 67-205 for my age group, and the mk677 for 2 weeks brought me beyond the high range for a young adult in their early 20's.
I couldn't be happier, this helps explain the increases in strength at the gym, as well as the fast recovery from workouts. Cardio on off days is a breeze. Not to mention mega pumps in the gym, a feeling of fullness all day in muscles, nootropic effects on brain of improved mood for me, enhanced energy all day, great sleep, zero lethargy for me everyday using it (I'm lucky in that aspect). I've even had rare days of less sleep due to schedule, and I still felt like a million bucks the next day being on mk677 as it gives you such great sleep with pleasant enhanced dreams many nights. As I am on a keto diet year round, there is minimal water retention in the face, both the minimal retention of water in face and hunger pains die down to zero after around 2 weeks on it, then it is smooth sailing.
I've continued to take bloodwork every few months, and this 372 igf-1 then falls to around 325 igf-1 (equivalent to 3.4iu HGH) for the rest of the 8 months, still remaining at 325 by the 7 month, when it starts to fall slightly to 300 around month 8, but I get off after 6 months, as that is how long it remains 100% effective without dipping at all from the peak (6 to 7 months it reamains 100% effective). I've taken blookwork every 1 of the 4 years I have used it....my baseline was at 225 the 2nd year I took it (after being off mk677 for several weeks)...it once again took me to the exact same high levels of 4iu pharm grade HGH year after year, each of the 4 years, remains 100% effective year after year, and your baseline never changes from normal.
--> The reason for the fall from 372 to 325 igf-1 is due to a "feedback loop" the body puts in place after being on mk677 for 3 weeks, in order to keep the levels from raising to high, the body will only maintain it at the HGH of around an 18 year old max.
My only concern is that maybe around 25% of people (like myself) never experience any lethargy on MK67, zero lethargy...however from the reviews I have read the other 75% of people do experience lethargy on it, in which case I would recommend NOT using it, it's just not worth it if it makes you tired. Find something else to use like peptides or HGH then.
MK677 should bring you to the high level of a young adult if you are already at the high end for an older adult.
Older folks (59-225ug/L)
young adult (116-358 ug/L)
My new discovery can be found if you google LSI LSD book
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