Ok, yeah that's what I was thinking ... A lot of guys here advocate higher e2 on cycle but only you will know what works best. I wont say stop using your Ai as that will help with the anxiety, but you can try if you are willing to experiment a bit, to let it rise to high 30's.
Otherwise, over stimulation of cns can lead to anxiety. Also, dht's can stimulate the glutamate, thus making you more anxious. I haven't figured out yet how to alleviate this, but this is a common problem. Including aas that are more dopaminergic and gaba-ergic can and does help (dbol, npp, ...). Also, your var can just be contaminated, degraded, or it maybe isn't var at all ...
Oh yeah, I just started taking 5-htp at 300mg's ed. It's doing wonders. And I've taken antidepressants, benzos, gapentins, etc ... Never thought an OTC product could help like this. Also, look into kava kava.
You can also try taking hCG if you arent already.