Both naturally lower, along with progesterone, as we age and when we go on TRT it drops fast because we are no longer naturally producing it. Some supplement with HCG to allow the pathway to continue, but many don't respond well to it- as in my case. I was recommended to add in pregnenolone a few years ago and let me tell you, there is NOTHING that made a bigger change in mood, energy, and memory. I had to play with it because it will aromatize at higher levels, especially if you take it with DHEA. You don't need a lot in most cases to move into the upper normal ranges. I take 25mg the day after injection on TRT and I inject e3.5d. This keeps me in a sweet spot without increasing e2 too much. I don't take any AI and avoid them.