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Prescription MK677

Old Witch said:
Like I tried to imply before, there is evidence to suggest that the bloating will actually diminish as the dosage rises above 40mg or so. So in this instance, if that were true, he benefit of a higher dose is actually LESS side effects, not more. How that works, from what I do understand, has to do with the other growth factors triggered by high levels of ghrelin. I may have misthought or misspoke when I mentioned IGF, because I think it’s specifically mgf and an enzyme that mobilizes fat that increase.
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Where is the evidence? Can you post it?
 
Heres some info with an article (and a study included) showing 10 and 50 mg doses of mk. It states virtually no difference in gh between the 10mg and 50 mg dose. But a significantly higher igf1 level at 50. It ALSO states there is little difference in igf1 from 25 mg to 50 mg. And the diminishing returns FACT of the drug.

So it is possible (though the exception and not the norm) hrt clinics would prescribe 40-50mg but imo its about making money and no real science to back up any extra benefits between 25-50 mg. If youre stating 100mg is somehow some magical number where this rule ceases to exist... Then id like to see that info please. If you could find it id be intersted fo sho.

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Godstrength said:
Heres some info with an article (and a study included) showing 10 and 50 mg doses of mk. It states virtually no difference in gh between the 10mg and 50 mg dose. But a significantly higher igf1 level at 50. It ALSO states there is little difference in igf1 from 25 mg to 50 mg. And the diminishing returns FACT of the drug.

So it is possible (though the exception and not the norm) hrt clinics would prescribe 40-50mg but imo its about making money and no real science to back up any extra benefits between 25-50 mg. If youre stating 100mg is somehow some magical number where this rule ceases to exist... Then id like to see that info please. If you could find it id be intersted fo sho.

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Well it’s 50mg twice a day, specifically, not 100mg at once. Maybe there’s some mojo with half lives here.
 
The half life is long right, so that doesn’t seem logical, yet there seems do be some debate as to whether splitting would be best for reasons unknown at this moment to me.
 
Old Witch said:
The half life is long right, so that doesn’t seem logical, yet there seems do be some debate as to whether splitting would be best for reasons unknown at this moment to me.
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Half life doesnt work like typical drugs here. Gherlin being a mimetic means that it simply promotes stronger GH pulses. So the body is merely pulsing according to its normal schedule (which is something like every 2nd hr or 12x per day) at a higher response rate releasing more gh and igf1. I dont see how splitting the dose would a) affect the timing of those pulses or b) create a larger amount of what the body is CAPABLE of producing since it is a mimetic and not an exterior introduction of the actual compounds (gh, igf1).

Ive shown an article with the study included. If theres nothing to refute that I'll stand on that footing.
 
Godstrength said:
Half life doesnt work like typical drugs here. Gherlin being a mimetic means that it simply promotes stronger GH pulses. So the body is merely pulsing according to its normal schedule (which is something like every 2nd hr or 12x per day) at a higher response rate releasing more gh and igf1. I dont see how splitting the dose would a) affect the timing of those pulses or b) create a larger amount of what the body is CAPABLE of producing since it is a mimetic and not an exterior introduction of the actual compounds (gh, igf1).

Ive shown an article with the study included. If theres nothing to refute that I'll stand on that footing.
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Ghrelin has its own effects in and of itself though entirely extraneous to GH production.
 
These studies are interesting when you look at the numbers. Yes GH and IGF are increased but so does abdominal fat and fat free mass actually decreases. Total body fat increases as well. You have to wonder if the positive effects of increased GH/IGF1 are outweighed by the negative effects of increased hunger, cortisol, and loss of insulin sensitivity.

For me personally MK677 kept me very lean after the 6 month mark. I could pretty much eat what I wanted.
 
user567 said:
These studies are interesting when you look at the numbers. Yes GH and IGF are increased but so does abdominal fat and fat free mass actually decreases. Total body fat increases as well. You have to wonder if the positive effects of increased GH/IGF1 are outweighed by the negative effects of increased hunger, cortisol, and loss of insulin sensitivity.

For me personally MK677 kept me very lean after the 6 month mark. I could pretty much eat what I wanted.
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Fat free mass decreased but lean body mass increased. This is arguably due to more muscles while eating more = more fatm in theory it can do both. This was with elderly people that probably eats sugar all day and doesn't work out, (that's what old people do)

Besides more muscle for an old person is huge
 
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