Yea and a big thing is the location of your piriforis muscle in comparison to the sciatic N. Different individuals have the sciatic N coursing through different locations, which is the biggest factor in whether or not you'll develop sciiatica. IMO, no Mk-677 will not alone solve your sciatica problems. I would focus on stretches and movement. Also who diagnosed you with sciatica? I'm in Chiro school right now and there's about 20 different orthopedic tests that if positive basically claim you have sciatica just because you have pain in your posterior leg, so it can be a generalized Diagnosis. Good luck man, I would take the Mk-677(bc it's so cheap), work on mobility, and possibly see a chiropractor or another medical professional. Maybe do some soft tissue work to help break up any potential adhesions