IGF-1 and Exemestane: Any Consensus?

sdstealth

New member
Can anyone comment on whether there been consensus achieved on the connection between IGF-1 levels and use of exemestane/Aromasin? I've seen conflicting reports on the way that different AIs affect IGF-1, and I'm especially curious if anyone can share both anecdotal and research-based info on how Aromasin may affect IGF-1. The conflicting reports are that many forum posts say that exemestane raises IGF-1, while others have said that it lowers it. To confound things, on another forum I've seen comments that Arimidex lowers IGF-1 while Aromasin raises it. I'd be grateful for any feedback, guidance, etc.

Many thanks!
 
From what I recall, most studies showed that aromasin raises igf-1 levels. It’s undoubtedly the best aromatize inhibitor out there. It also lowers shbg, which made a big difference in my bloodwork.
 
AnabolicGuru said:
From what I recall, most studies showed that aromasin raises igf-1 levels. It’s undoubtedly the best aromatize inhibitor out there. It also lowers shbg, which made a big difference in my bloodwork.
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Great, thanks. That's good to know. I actually had bloodwork come back with IGF-1 over the range, and I've been concerned as I don't want to have acromegaly. I've been using exemestane to control my E2 on long-term TRT and am going to come off the Aromasin to see if that helps correct the IGF-1 level. But I'm also trying to do some research to determine if there could be a correlation between elevated IGF-1 levels and my use of Aromasin.
 
just heard an interesting q&a with dr. saya yesterday. he said he prefers anastrozole, because exemestane, being a steroid *might* antagonize the androgen receptor - he said the data isn't clear on that yet (don't know how correct he is). I've used both but never pulled igf-1. anecdotally (worth almost zero) my libido seems better on anastrozole with same e2 levels?. i may research this a bit more - definitely dont want androgen receptor antagonism. but same - always heard exemestane was the bee's knees as an ai.
 
Interesting, thanks. It definitely resolves my high E2 symptoms but I have to figure out why my IGF levels are elevated, so I'm trying to rule this out.
 
Okay, here's a bit of research I found. Looks like in women with breast cancer, exemestane was associated with a 35% increase in IGF-1 levels after a 120-day window.

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acromegaly - in one study of active versus remission acromegaly, the active group igf-1 readings were 558 ± 206 in the males. also, from what i read, in normal people, high igf-1 levels are sensed by the body and it lowers gh secretion as a result. it seems that just having a high igf-1 won't give you acromegaly - your negative feedback loop would have to be broken. also, women are taking 25mg of exemestane every day and not developing it. just some thoughts - anastrozole works fine too :-)
 
Aromasin nolva is the way to go during pct. For cycle arimidex or letro can be more efficient with estro (not taking health in to consideration where aromasin is best). Problem during pct is that both arimidex and letro will lose efficency while aromasin doesn't. Stacking adex or letro with nolva will decrease blood plasma during pct. And yes aromasin do increase igf1
 
DaeshDontSurf said:
acromegaly - in one study of active versus remission acromegaly, the active group igf-1 readings were 558 ± 206 in the males. also, from what i read, in normal people, high igf-1 levels are sensed by the body and it lowers gh secretion as a result. it seems that just having a high igf-1 won't give you acromegaly - your negative feedback loop would have to be broken. also, women are taking 25mg of exemestane every day and not developing it. just some thoughts - anastrozole works fine too :-)
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Yeah I'm in the middle of an oral glucose tolerance test right now to check for active acromegaly. My IGF-BP3 is also above the range (about 40% + ULN) so my body is sensing that something is up, but not clear what the deal is.
 
I preferred adex on cycle, just worked. no more than half a mg A week was perfect. PCT I'm using nolva and aromasin and just posted my results in another thread.

Man, don't you have to do an insane amount of GH to get this condition like John cena or the rock? I don't even think you'd be at risk using mk677 for two years with that happening. But I could be wrong.
 
YamahaC76 said:
Man, don't you have to do an insane amount of GH to get this condition like John cena or the rock? I don't even think you'd be at risk using mk677 for two years with that happening. But I could be wrong.
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I've never done HGH or used mk677. I'm a long-term TRT patient. The issue may be a pituitary tumor that's unrelated to any substance use. We're evaluating to determine the cause of the elevated IGF-1 as there isn't a good explanation at this point. The most common cause of this is a pituitary adenoma (benign tumor) that produces excess GH. The IGF-1 is a downstream indicator of elevated GH levels. I had an OGTT yesterday to determine if my GH level is suppressable via intake of glucose.
 
DaeshDontSurf said:
acromegaly - in one study of active versus remission acromegaly, the active group igf-1 readings were 558 ± 206 in the males. also, from what i read, in normal people, high igf-1 levels are sensed by the body and it lowers gh secretion as a result. it seems that just having a high igf-1 won't give you acromegaly - your negative feedback loop would have to be broken. also, women are taking 25mg of exemestane every day and not developing it. just some thoughts - anastrozole works fine too :-)
Click to expand...

Just to circle back on this, I got the results of my oral glucose tolerance test today. Completely normal at all time intervals on the test, with a fully-suppressed GH level. So whatever the cause of my elevated IGF-1, it doesn't seem to be a pituitary tumor secreting growth hormone. My body detects the rise in glucose levels and is able to both produce and respond to insulin and drop the levels of GH. The mystery deepens!
 
DaeshDontSurf said:
acromegaly - in one study of active versus remission acromegaly, the active group igf-1 readings were 558 ± 206 in the males. also, from what i read, in normal people, high igf-1 levels are sensed by the body and it lowers gh secretion as a result. it seems that just having a high igf-1 won't give you acromegaly - your negative feedback loop would have to be broken. also, women are taking 25mg of exemestane every day and not developing it. just some thoughts - anastrozole works fine too :-)
Click to expand...

I just got my MRI report. They only used a 1.5T magnet (vs the higher resolution 3T magnet), but there was no large/apparent tumor of any kind and the pituitary and sella appear normal. Here's what that section says: "The pituitary gland size is within normal limits. There is slightly heterogeneous enhancement with no definitive lesion identified. The infundibulum is midline. The suprasellar cistern is patent. The cavernous sinuses enhance symmetrically. The visualized paranasal sinuses are clear."

So either I have a microadenoma small enough that it couldn't be resolved on a 1.5T magnet, or there's no pituitary tumor.

The mystery continues to deepen.
 
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