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Study claims that Pregnenolone sulfate may cause loss of libido.

tronatula

New member
These results suggest that pregnenolone sulfate has inhibitory effects on olfactory mediated male sexual interest, preference, or 'motivation' that, in part, involve interactions with NMDA receptor mediated mechanisms.

(Male preference for the odors of estrous female mice is reduced by the neurosteroid pregnenolone sulfate.)
 
tronatula said:
These results suggest that pregnenolone sulfate has inhibitory effects on olfactory mediated male sexual interest, preference, or 'motivation' that, in part, involve interactions with NMDA receptor mediated mechanisms.

(Male preference for the odors of estrous female mice is reduced by the neurosteroid pregnenolone sulfate.)
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Does that mean: If I take Pregnenolone sulfate, I get less aroused by the smell of a woman?
 
tronatula said:
I don't know exactly. However, some people experience lower libido after taking pregnenolone, so I think this study may explains why.
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1. It's mice.
2. I'm on TRT and take DHEA, and Pregnenolone and I can assure you my libido is really-really-really just fine.
3. :D

I just don't care how women smell. It must be a mouse thing.
 
justhere4comm said:

1. It's mice.
2. I'm on TRT and take DHEA, and Pregnenolone and I can assure you my libido is really-really-really just fine.
3. :D

I just don't care how women smell. It must be a mouse thing.
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"Male preference for the odors of estrous female mice is reduced" is a scientific way of "loss libido". You should not understand it litterally. How can we know mice libido? Ask them?

Mice study is of course cannot speak for human 100% but cannot be ruled out completely either.

You take DHEA and on TRT, of course your libido will not be impaired even with pregnenolone.
 
I love that commercial! "She washed this 3 months ago, how's a guy supposed to forget!....." lol.


Who would take Pregnenolone stand alone? It's the mother of all hormones but DHEA would be more appropriate stand alone which it converts to anyway among other things. Silly study wasting tax payers money on mouse sexiness. Were they dressed attractively? Wearing perfume? Were they in good shape for sexy time? I need to know.
 
tronatula said:
I don't know exactly. However, some people experience lower libido after taking pregnenolone, so I think this study may explains why.
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Who are some people? Why not all people? How much Preg did these "some people" take? What were their starting Preg levels? What else were these "some people" taking/doing? I thought Human Males were mostly visual? (larger amount of androgen receptors in the visual cortex). People aren't mice, and it depends on the system being looked at, on whether it *is* applicable to people - it most definitely isn't always "might apply" with rodents. How many failed human things that worked in mice are there? A LOT.

Anyway, post a link to the study next time: Invalid Link Removed
Abstract only, unless you want to pay money. The HED of what was used in the study would be 80mcg-80mg in a 220lb man. The healthy range for males is 13-208ng/dl. LEF recommends 180ng/dl as optimal. The blood test for it costs about $115.
 
The_Old_Guy said:
Who are some people? Why not all people? How much Preg did these "some people" take? What were their starting Preg levels? What else were these "some people" taking/doing? I thought Human Males were mostly visual? (larger amount of androgen receptors in the visual cortex). People aren't mice, and it depends on the system being looked at, on whether it *is* applicable to people - it most definitely isn't always "might apply" with rodents. How many failed human things that worked in mice are there? A LOT.

.
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Don't you know that both male and female are attracted by other smell? Study claims that, google it yourself.

About "some people", just search "Pregnenolone libido" (you don't even put in "bad libido" or "loss of libido")

I cannot post link because it requires 100 posts.
 
tronatula said:
Don't you know that both male and female are attracted by other smell? Study claims that, google it yourself.
About "some people", just search "Pregnenolone libido" (you don't even put in "bad libido" or "loss of libido")
I cannot post link because it requires 100 posts.
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We are all aware of scent, and even pheromones as they relate to involuntary sexual attraction, but we are saying the relationship to scent as it is displayed in the mice experiment where only the abstract is shown. I don't have a subscription to see the rest of it, and am willing to wager it's a drop in the ocean of potentiality that has no consequence or very little with the relationship of sexual attraction between humans.

To what end does this even matter? Pregnenolone is the mother of all hormones responsible for far more than what you are discussing. It's a bit of a myopic over simplification focusing on something that is probably irrelevant.

Have a look at the bigger picture here:


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​
 
Holy mackerel that chart is hard to read. Try these instead:
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tronatula said:
Don't you know that both male and female are attracted by other smell?
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I can't smell the chick in a porn on my computer screen - yet I still seem to get a boner? We are more visual than olfactory (note I said more, not that we don't use any smell at all). You telling me you can smell a hot chick on the other side of the Olympic pool in Vegas?
 
justhere4comm said:
We are all aware of scent, and even pheromones as they relate to involuntary sexual attraction, but we are saying the relationship to scent as it is displayed in the mice experiment where only the abstract is shown. I don't have a subscription to see the rest of it, and am willing to wager it's a drop in the ocean of potentiality that has no consequence or very little with the relationship of sexual attraction between humans.
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1/ From the full text version:

These results demonstrate that the neurosteroid, PS, dose-relatedly (0.01 and 1.0 mg/kg) decreases the preference for and interest in the odors of an estrous female. Pregnenolone sulfate at 0.01 mg/kg had no significant effect on the responses to the odors of a non-estrous female, suggesting a direct effect of PS on sexually motivated or related behavior rather than a non-specific response to female odors. Investigations of the locomotory effects of PS using a computerized multivariate open field have shown that PS at 0.01 mg/kg increases, while PS at 10 mg/kg decreases activity [[19], in preparation]. These disparate effects of PS on locomotory behavior make it highly unlikely that changes in activity contributed to the altered olfactory preferences. Pregnenolone sulfate was also observed to increase male avoidance of the odor of a predator (unpublished data), further indicating that PS does not just non-specifically alter olfactory responses

2/ Oral administration of 50 or 100 mg pregnenolone has been found to have minimal or negligible effect on urinary levels of testosterone and testosterone metabolites, including of androsterone, etiocholanolone, 5β-androstanediol, androstadienol, and androstenol (and/or their conjugates), and this suggests that only a small amount of pregnenolone is converted into testosterone.[17][18] This is in accordance with findings on the conversion of DHEA into testosterone, in which only 1.5% of an oral dose of DHEA was found to be converted into testosterone.[17] In contrast to the androstanes, 50 or 100 mg oral pregnenolone has been found to significantly and in fact "strongly" increase urinary levels of the progesterone metabolites pregnanediol and pregnanolone (and/or their conjugates), whereas pregnanetriol was unaffected.[17][18] Unlike the case of oral administration, transdermal administration of 30 mg/day pregnenolone cream has not been found to affect urinary levels of metabolites of any other steroids, including of progesteron

source: wiki
 
tronatula said:
1/ From the full text version:

These results demonstrate that the neurosteroid, PS, dose-relatedly (0.01 and 1.0 mg/kg) decreases the preference for and interest in the odors of an estrous female. Pregnenolone sulfate at 0.01 mg/kg had no significant effect on the responses to the odors of a non-estrous female, suggesting a direct effect of PS on sexually motivated or related behavior rather than a non-specific response to female odors. Investigations of the locomotory effects of PS using a computerized multivariate open field have shown that PS at 0.01 mg/kg increases, while PS at 10 mg/kg decreases activity [[19], in preparation]. These disparate effects of PS on locomotory behavior make it highly unlikely that changes in activity contributed to the altered olfactory preferences. Pregnenolone sulfate was also observed to increase male avoidance of the odor of a predator (unpublished data), further indicating that PS does not just non-specifically alter olfactory responses

2/ Oral administration of 50 or 100 mg pregnenolone has been found to have minimal or negligible effect on urinary levels of testosterone and testosterone metabolites, including of androsterone, etiocholanolone, 5β-androstanediol, androstadienol, and androstenol (and/or their conjugates), and this suggests that only a small amount of pregnenolone is converted into testosterone.[17][18] This is in accordance with findings on the conversion of DHEA into testosterone, in which only 1.5% of an oral dose of DHEA was found to be converted into testosterone.[17] In contrast to the androstanes, 50 or 100 mg oral pregnenolone has been found to significantly and in fact "strongly" increase urinary levels of the progesterone metabolites pregnanediol and pregnanolone (and/or their conjugates), whereas pregnanetriol was unaffected.[17][18] Unlike the case of oral administration, transdermal administration of 30 mg/day pregnenolone cream has not been found to affect urinary levels of metabolites of any other steroids, including of progesteron

source: wiki
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"wiki" isn't always the most credible source.
 
I'm going to say, nobody cares about the study in here as they aren't on just pregnenolone so it doesn't effect them. Thanks though.
 
tronatula said:
Number 1 is from the full text of the study, it is not from Wiki.

Number 2 is from wiki, but there are legit references.
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That's great. I would recommend just going straight to the source links then. It'll save you some time explaining more about sources, and it'll give your post more credibility. Again, wiki is not reliable and trustworthy. There's a reason why you never hear journalists says "According to wikipedia...."
 
tronatula said:
These results suggest that pregnenolone sulfate has inhibitory effects on olfactory mediated male sexual interest, preference, or 'motivation' that, in part, involve interactions with NMDA receptor mediated mechanisms.

(Male preference for the odors of estrous female mice is reduced by the neurosteroid pregnenolone sulfate.)
Click to expand...

wow...this explains homosexuality...males given pregnenolone as youngsters.:chairfall:
 
I can't believe I missed this thread either, especially hairygrandpa's absolutely perfect placed post.
 
thebigt said:
wow...this explains homosexuality...males given pregnenolone as youngsters.:chairfall:
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Am I missing something here? I admittedly haven’t read the full text of the study in question, but wouldn’t sexual disinterest in females just lead to a lack of sexual interest for a heterosexual male? I don’t see a mention of the preference shifting towards that of other males, so it would likely explain, if anything, people with no sexual interest, not people with homosexual attraction.

Of course, it’s also possible (likely) that your post was just a joke haha.
 
muscleupcrohn said:
Am I missing something here? I admittedly haven’t read the full text of the study in question, but wouldn’t sexual disinterest in females just lead to a lack of sexual interest for a heterosexual male? I don’t see a mention of the preference shifting towards that of other males, so it would likely explain, if anything, people with no sexual interest, not people with homosexual attraction.

Of course, it’s also possible (likely) that your post was just a joke haha.
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it's thebigt, it was a poke to rile up people on homosexuality. I'd call it a half joke. lol
 
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