This will be a long post...to summarize, Butea Superba is safe as long as you don't take ridiculous amounts...
From EvoMuse Testruction Write-Up...hope you don't mind Matt
Bueta Superba is an interesting Thai herb, widely considered to have aphrodisiac qualities. Along the lines of the aphrodisiac aspect, it has been shown to increase penile erections in diabetic rats (diabetes frequently interferes with normal erectile function) (11).
This benefit has also been demonstrated in humans. Thai males aged 30-70 with erectile dysfunction were given BS in a randomized, double-blind study for 3 months, and 82% of them saw noticeable improvements in sexual function (12).
When a compound has libido boosting effects, chances are pretty good that we’ll see some positive interaction with testosterone and/or DHT, which is exactly what we see with BS. If one were to look solely at the 2008 rat study from Cherdshewasart, et al., it would appear that BSE could actually lower testosterone when taken at high doses, and even elevate liver enzymes (13). However, there’s a couple of things to keep in mind here. One, when taking prohormones or steroids, the body drops production of its own testosterone to compensate, which is likely what is happening here. And two, the rest of the published data tells a different story, in fact, another rat study using an even higher dose of BSE resulted in increased testis weight and sperm count, and found it to be safe with no adverse side effects at 100x the Thai recommended dose for humans (14).
BS has also been shown to be anti-estrogenic and androgenic in several other studies, as well as being deemed to work in conjunction, and synergistically with the body’s own testosterone levels similar to E. Ulmoides (14–17).
In a 2012 case study, a patient came in "complaining” of an increased sex drive. Lab testing revealed elevated levels of Free Testosterone, DHT, and DHEA-sulfate, and was thus diagnosed as having hyperandrogenemia (aka elevated androgens, sounds like a good problem to have). After assessing current supplement intake, the patient was advised to stop taking BS. One week after cessation, the patient’s sex drive had returned to normal and lab testing showed DHT had dropped back to normal (18).
BSE also appears to have some positive effects on the brain. Research shows it can increase neurogenesis in the hippocampus, relieve depression-like symptoms induced by chronic stress, ameliorate cognitive dysfunction, and inhibit acetylcholinesterase thereby elevating acetylcholine levels (19,20).
And some of the studies this refers to...
Luteinizing hormone reduction by the male potency herb, Butea superba Roxb.
Malaivijitnond S1, Ketsuwan A, Watanabe G, Taya K, Cherdshewasart W.
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Abstract
To determine if Butea superba Roxb., a traditional Thai male potency herb, has androgenic activity in 60-day-old male Wistar rats, we measured its effects on the pituitary-testicular axis and sex organs. Intact and orchidectomized adult male rats were subdivided into five groups (10 rats/group): distilled water, Butea superba (BS)-10, BS-50, BS-250, and testosterone propionate (TP). They received 0, 10, 50, and 250 mg·kg body weight(-1)·day(-1) BS in distilled water by gavage and 6 mg·kg body weight(-1)·day(-1) TP sc, respectively, during the 30-day treatment period. Blood was collected every 15 days and luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone were measured. Changes of weight and histological appearance of sex organs were determined at the end of the 30-day treatment and 15-day post-treatment periods. TP treatment reduced serum FSH and LH levels and significantly increased the weight of the seminal vesicles and epididymis, in accordance with histopathological changes, in both intact and orchidectomized rats. No changes in serum testosterone, LH, and FSH levels were observed in any of the intact rats treated with BS, but a significant increase in seminal vesicle weight was observed only in the BS-250 group. Although a significant reduction in serum LH was detected in the BS-50 and BS-250 groups of orchidectomized rats, no significant change in weight or histology of sex organs was observed. Thus, we conclude that B. superba needs endogenous testosterone to work synergistically to stimulate the accessory sex organ of intact animals and can potentially exhibit an LH reduction effect in orchidectomized animals.
Mutagenic and antimutagenic effects of the traditional herb used for treating erectile dysfunction, Butea superba Roxb.
Cherdshewasart W1, Sutjit W, Pulcharoen K, Chulasiri M.
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Abstract
Butea superba is a traditional tuberous Thai plant enriched with flavonoids that is used for treating erectile dysfunction. We investigated the mutagenic and antimutagenic potentials of a B. superba extract by using the pre-incubation method of the Ames test. Salmonella typhimurium strains TA 98 and TA 100 were applied as the tester strains in the presence and absence of an S9 mixture. Prior to the mutagenic and antimutagenic tests, the survival of the tester strains was measured by treating with the B. superba extract. The results show that the B. superba extract exhibited dose-dependent cytotoxic effects. Data from the Ames test revealed that the B. superba extract to be non-mutagenic in the presence and absence of the S9 mixture. In contrast, the B. superba extract showed antimutagenic potential towards either or both of the tested mutagens: 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide (AF-2) and benzo(a)pyrene (B(a)P) in the respective presence and absence of the S9 mixture, respectively. The plant antimutagenic activity was confirmed by a rec assay. A further study by micronucleus test demonstrated that the B. superba extract at the maximum loading volume could induce acute micronucleus formation in the tested animals. The in vitro mutagenic and antimutagenic assays confirmed the safe consumption of B. superba products at low dose (not more than 781.25 microg/ml of the plant extract), but the in vivo genotoxic assay demonstrated the unsafe consumption at a high dose (300 mg/kg of the BW plant extract or 16 g/kg of the BW plant powder).
Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction.
Cherdshewasart W1, Nimsakul N.
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Abstract
AIM:
To study the effect of Butea superba on erectile dysfunction (ED) in Thai males.
METHODS:
A 3-month randomized double-blind clinical trial was carried out in volunteers with ED, aged 30 years approximately 70 years, to evaluate the therapeutic effect of the crude preparation of Butea superba tubers on ED.
RESULTS:
There was a significant upgrading in 4 of the 5 descriptive evaluations of the IIEF-5 questionnaire. Estimation of the sexual record indicated that 82.4% of the patients exhibited noticeable improvement. Haematology and blood chemistry analysis revealed no apparent change.
CONCLUSION:
The plant preparation appears to improve the erectile function in ED patients without apparent toxicity.
Effects of Butea superba on reproductive systems of rats.
Manosroi A1, Sanphet K, Saowakon S, Aritajat S, Manosroi J.
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Abstract
The effects of Butea superba on the reproductive system in male Wistar rats were investigated. The animals were fed daily with the powdered crude drug suspended in distilled water by a gastric tube at the dose of 2, 25, 250 and 1250 mg/kg body weight for 8 weeks. Rats fed with 1 ml of distilled water were used as a negative control. The weights of all vital organs in all treated groups were not different from the control. The percentage weight ratios of body weights of seminal vesicles and prostate glands were not different from the control, except that the testis of the group fed with 1250 mg/kg was significantly different from the control and the other treated groups. In addition, the sperm counts in this group showed about 16% more than the control group. Hematology as well as the liver and kidney function of all treated groups showed no difference from the control. B. superba, drug at 250 mg/kg which was 100 times more than the Thai FDA recommended dose for humans appeared to be safe in rats. The crude drug has demonstrated an increase tendency on testis weight and sperm counts in rat.