My first 10 days on Ecdysterone - Long log/review

[thesinner]

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Here's a picture of 20-hydroxyecdysterone. As Vrunda said, it's a little over 480 amu. Most transdermal PH's are only about 300. That little tail on the pentane ring doesn't look too promising either for TD.






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Anyhow, here's a picture of Turkesterone, just to give you guys an idea of how similar 20-hydroxy and turkesterone really are. The only difference I can see is a hydroxyl group on the left hexane ring. I don't know too much about ecdysterone's metabolic reactions, so I can't say how much of a difference the OH is going to make.





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Lastly, here's Rubrosterone. This one is one of the ecdysteroids found in Product-X by legal gear. I calculated it's MW at about 330 amu. As you can see, it not only lost it's tail, but has a much lower MW. This particular ecdysteroid could hold some promise as far as delivery through the skin, but I don't know how important that cholesterol tail is to the effectiveness of these compounds.


Also, what about using DHB or bioprine to enhance oral absoption?

 

[oswizzle]

Turkesterone is the most anabolic of all the Ecdysteroids....i heard u gotta dose it at a minnimun if a 100mg a day to see its effects..to find that **** in its pure form is hard as hell dude

 

[mywetnightmares]

Maybe someone should put out a product. Could it be esterified, maybe a long ester pain free oral would be cool, especially if it's as safe as regular ecdy. How awesome would that be to have one shot a week that you never had to come off of. I know I'm probly be dreaming but it would still be cool.

 

[mywetnightmares]

[Effect of phytoecdysteroids and nerobol on parameters of carbohydrate and lipid metabolism and phospholipid spectrum of liver mitochondrial membrane in experimental diabetes mellitus of rats]

[Article in Russian]

Syrov VN, Tashmukhamedova MA, Khushbaktova ZA, Mirtalipov DT, Mamatkhanov AU.

Phytoecdysteroids: ecdysterone and turkesterone, introduced orally to male rats with the body mass 180-120 g in a dose of 5 mg/l kg of mass and nerobol in a dose of 10 mg per 1 kg of the mass for 15 days against a background of the developed alloxan diabetes cause a considerable decrease in the content of free fatty acids of the blood serum, sharply increased after the subcutaneous injection of alloxan to the animals (150 mg per 1 kg of the mass). The content of glycogen, malonic dialdehyde, pyruvic acid and calcium transporting function of the liver mitochondria are also normalized. These changes are closely interrelated (and may be mutually conditioned) with the preparation-induced reduction of phospholipid spectrum of the liver mitochondrial membranes pathologically changed owing to insulin insufficiency. In this case phytoecdysteroids in the first turn normalize the fractions of phospholipids which play the structural role in the mitochondrial membranes, and nerobol normalizes the level of minor and monoacylic phospholipids.


[The results of experimental study of phytoecdysteroids as erythropoiesis stimulators in laboratory animals]

[Article in Russian]

Syrov VN, Nasyrova SS, Khushbaktova ZA.

Phytoecdysteroids alpha-ecdysone, 2-desoxyecdysterone, ecdysterone, sileneoside A, and turkesterone isolated from Rhaponticum carthamoides (Willd.) IIjin, Silene brahuica Boiss and Ajuga turkestanica (Rgl.) Repeated administration of brig increased the content of erythrocytes and hemoglobin in the blood of intact rats. The most active of them--ecdysterone, sileneoside A, and, particularly turkesterone, cause also a marked effect on red blood regeneration in hemotoxic phenylhydrazine anemia. In its capacity for simulating erythropoiesis turkesterone resembles the well-known steroidal anabolic drug nerobol.


[Experimental study of pharmacotherapeutic effect of phytoecdisteroids and nerobol in toxic liver damage]

[Article in Russian]

Syrov VN, Khushbaktova ZA.

Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, ul. Kh. Abdulaeva 77, Tashkent, 700170 Uzbekistan.

Phytoecdysteroids ecdysteron and turkesteron isolated from Ajuga turkestanica (Rgl.) Brig. decrease the manifestations of uremic intoxication in rats with experimental renal pathology induced by a nephrotoxic mixture (containing uranyl acetate and glycerol). Injected in a dose of 5 mg/kg, the drugs restore glomerular filtration level, favor the disappearance of the albuminuria and normalize urinary sediments. The nephroprotector effect of the phytoecdysteroids studied resembles the action of a steroidal anabolic drug nerobol.


[An experimental study of the hepatoprotective properties of phytoecdysteroids and nerobol in carbon tetrachloride-induced liver lesion]

[Article in Russian]

Syrov VN, Khushbaktova ZA, Nabiev AN.

The phytoecdisteroids ecdisterone, turkesterone and cyasterone were administered in a dose of 5 mg/kg per os to rats with hepatitis induced by subcutaneous injections of CCl4. Similarly to the anabolic drug nerobol (10 mg/kg), the above agents not only interfere with the manifestation of the hepatic action of CCl4 (in this case the effect of the phytoecdisteroids is more remarkable) but also favour a more rapid normalization, as compared to the control, of functional and metabolic disorders in the liver. The phytoecdisteroids and nerobol noticeably stimulate the recovery of bile secretion, the synthesis of bilirubin and bile acids, cholesterol excretion.

 

[Beau]

I don't think ecdysterone is all that great after trying it, but that's bot a bad price you found on it.

I normally do not "plug" anyone other than board sponsors - but BAC is a really good company, for those things not offered by board sponsors.

 

[Mechbot]

I'm just thinking maybe cycling this product, or has someone here done this already?
I wonder if this will be like d-aspartic acid, works for a couple of weeks then return to baseline? Hence cycling DAA.

 

[The Express 42]

I'm just thinking maybe cycling this product, or has someone here done this already?
I wonder if this will be like d-aspartic acid, works for a couple of weeks then return to baseline? Hence cycling DAA.

DAA is a blatant waste of money, and way to revive a thread over a decade old haha. I think MassMax XT has something like this involved. Maybe a rep can help you, but look into that

 

[cubsfan815]

I'm just thinking maybe cycling this product, or has someone here done this already?
I wonder if this will be like d-aspartic acid, works for a couple of weeks then return to baseline? Hence cycling DAA.

Wow 11 year bump.

MassMax XT is the ECDY product you would want to try. Check out the logs on it, both sponsored and unsponsored. And I agree with above DAA sucks.

 

[jameschoi]

They got real muscle for 59 bucks with a 40% off coupon for their ecdy product, might try that.

 

[muscleupcrohn]

They got real muscle for 59 bucks with a 40% off coupon for their ecdy product, might try that.

If I'm looking at the right 'Real Muscle' supplement, it looks like their ecdy sources aren't standardized for anything. Maybe they have a quality extract, but I'm not sure. Like cubsfan mentioned, MassMax XT contains a quality ecdy source, and also epicatechin like Real Muscle has, but MassMax XT has 250mg per serving instead of just 50, plus MMXT has other ingredients to help with absorption. I'd definitely recommend it if you want to try a supplement with ecdy, and the feedback on it has been solid too.

 

[jameschoi]

If I'm looking at the right 'Real Muscle' supplement, it looks like their ecdy sources aren't standardized for anything. Maybe they have a quality extract, but I'm not sure. Like cubsfan mentioned, MassMax XT contains a quality ecdy source, and also epicatechin like Real Muscle has, but MassMax XT has 250mg per serving instead of just 50, plus MMXT has other ingredients to help with absorption. I'd definitely recommend it if you want to try a supplement with ecdy, and the feedback on it has been solid too.

I will try Mass Max XT after this real muscle run. For $36 you get a 45 day supply so hopefully it works out for me.

 

[cubsfan815]

I will try Mass Max XT after this real muscle run. For $36 you get a 45 day supply so hopefully it works out for me.

If that's nutriverse, don't forget AM5 for additional savings. Makes it $34.

It is 30 day supply, however it's still more than worth it.

 

[Mechbot]

Yes it is a waist of money,
Unless your over 40 and have started feeling effects of age related test decline.
Then it will give an effect. Although i heard recently that this cycling on daa is not true and there arent any scientific back up on it loosing strength. It was suggested to cycle because of lack of human study on humans.

 

[muscleupcrohn]

Yes it is a waist of money,
Unless your over 40 and have started feeling effects of age related test decline.
Then it will give an effect. Although i heard recently that this cycling on daa is not true and there arent any scientific back up on it loosing strength. It was suggested to cycle because of lack of human study on humans.

What is a waste of money unless you're over 40? Ecdy isn't a test booster, nor are either of the two products just mentioned.

Also, if you're talking about ingredients that won't do anything unless you're old and have low-T, is put DAA at the top of that list. Recent studies have shown no benefits in healthy young subjects, and even decreases in T with higher dosing. So I wouldn't recommend cycling DAA, but that's just because I wouldn't recommend using it at all. Im not sure what DAA has to do with an ecdy thread though?

 

[jameschoi]

Just got my Real Muscle, will start 4 caps tomorrow.

 

[dramaticphysique]

Bumping a very old thread because I'm currently running my own injectable ecdy. Here's the bullet points to bring up to date:

- Ecdy isn't very water soluble in itself but is nicely water soluble when complexed with cyclodextrin
- Oral bioavailability is somewhere around 1-3% depending on how it is complexed
- Can cause increases in blood pressure- keep an eye on that
- Rat studies for muscle growth used 5mg/kg. I've been on 100 mg/day at 90 kg and it's too much
- Works on the estrogen receptor beta which causes neurogenesis and consequently brain fog, see above
- 25-50 mg per day micro shot (.25 ml) sub Q is a decent place to start
- Just because it isn't naturally water soluble doesn't mean it's oil soluble: BB causes weird reaction/clumping and always separates out of any carrier oil
- I'm developing my own custom hydro-gel carrier that uses BA as a anti-bacterial and solvent
- In the 15-20 years since this post began, quality ecdy is much easier to source
- As near as I can tell, the standard 1000-3000 mg per day oral dose translates as 10-30 usable mg/day
- 50-75 mg per day may be a sweet spot, use a hydrogel delivery for injection and watch the blood pressure (I have high blood pressure as is and have not noticed any increase thus far from Injectable ecdy)