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Semax

ELROCK said:
I have been keeping an eye on both of these. I would like to give both of them a run. It seems PRL gets a little better user feedback then the P21. The P21 since it is newer and had less overall feedback, but it seems to be hit or miss with people. Some say they don't notice anything from it while others claim to love it. Did the PRL bring on any anxiety issues with you?
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Dr Hansl who developed PRL853 also developed PRL 8-147. Google PRL 8-53 and PRL 8-147: The Mystery The 8 147 has a very interesting story behind it. It's supposed to be the best noot ever.

I have no anxiety issues a t all from the PRL853. will post my thoughts on itThursday. I have been reading alot about P21, NSI-189 and Orexin.
 
PLR 8-147: The Most Powerful Memory Enhancer?
Even in the late 70′s before nootropics started to gain popularity research uncovered some potent smart drugs. Some of these have been largely forgotten, despite the powerful benefits they may provide. One exceptional example is PLR 8-147. There has been little research performed on this compound for over 20 years. This is unfortunate because the research that has been done suggests it may be one of the most potent nootropic drugs ever developed.

PLR 8-147 and Memory
In High Frontiers, Durk Pearson describes the powerful mental benefits of PLR 8-147. An average person can memorize about 7 or 8 digits after looking at them for a second or two. With PLR, it is reported that this number jumps to an astounding 21 to 22 digits. This is an astounding 275% increase in memory. (For this specific test at least) He also states that a person suffering from amnesia was cured by a single dose.

The clinical studies I’ve been able to find aren’t quite as optimistic, but still suggest that PLR 8-147 could have potential as a powerful nootropic. In a clinical study by Nikolaus Hansl, volunteers who used PLR 8-147 displayed an improvement in verbal memory of 80%. This backs up earlier studies which have found similar boosts to memory from the drug. These benefits aren’t just limited to verbal memory either. One study exposed subjects to various geometric patterns, which they were later asked to draw from memory. As in previous studies, PLR 8-147 had a significant impact on the ability of the subjects to complete the task. Further studies using PLR 8-147 showed it to also improve the ability to perform mental math.

Other Benefits and Mechanism of Action
While human studies on PLR 8-147 have been limited to humans, tests to determine whether it may improve higher cognitive functions such as correlation and problem solving have only been performed on animals. Subjects in these studies also showed extremely significant improvements.

We still know very little about how PLR 8-147 works, besides that one of it’s main mechanisms of action is to enhance the brain’s response to the neurotransmitter acetylcholine. (Acetylcholine plays a vital role in learning and memory). We can only hope that as nootropics become more and more popular that there will be renewed interest in PLR 8-147; if it proves as effective as current research suggests the first company to bring it to market could stand to make a fortune.
 
PRL853 Update


PRL853 is crazy for memory recall. It helps me to memorize information better and provides noticeable increases in ability to recall information. Here is an example. I am doing a kitchen bid proposal and going over all the different finishes. Instead of constantly looking at my notes, I am able to I remember almost all of ideas. The best part about this is my client notices this too. After trying different dosages, I now use 10mgs. It kicks in quick and taste horrible.

The whole nootropic thing really intrigues me. I started researching and using them about 2 years ago. I started with the basics ALCAR, Choline Bitartrate, herbals and my 1st racetam was Piracetam. It was just a matter of testing them on myself and seeing which ones actually worked for me. I used all the different vendors until I found the best. Now I only use 2.


For me my perfect stack would be:

A. SEMAX or noopept for to boost my creativity and concentration.I am able to perceive colors and objects in HD fashion. I really like Semax vs noopept

B. PRL853 for the memory boost.

C. Phenylpiracetam, Modafinil, Armodafinil to boost mental focus.
 
JohnP. said:
PRL853 Update


PRL853 is crazy for memory recall. It helps me to memorize information better and provides noticeable increases in ability to recall information. Here is an example. I am doing a kitchen bid proposal and going over all the different finishes. Instead of constantly looking at my notes, I am able to I remember almost all of ideas. The best part about this is my client notices this too. After trying different dosages, I now use 10mgs. It kicks in quick and taste horrible.

The whole nootropic thing really intrigues me. I started researching and using them about 2 years ago. I started with the basics ALCAR, Choline Bitartrate, herbals and my 1st racetam was Piracetam. It was just a matter of testing them on myself and seeing which ones actually worked for me. I used all the different vendors until I found the best. Now I only use 2.


For me my perfect stack would be:

A. SEMAX or noopept for to boost my creativity and concentration.I am able to perceive colors and objects in HD fashion. I really like Semax vs noopept

B. PRL853 for the memory boost.

C. Phenylpiracetam, Modafinil, Armodafinil to boost mental focus.
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Good stuff man! Thanks for the feedback! I will be joining you with 10mg of PRL 8-53 shortly. I will probably give it a try next month. I will probably order the NA-Semax around that time too. I will try PRL 8-53 solo though before I start stacking.
 
ELROCK said:
Good stuff man! Thanks for the feedback! I will be joining you with 10mg of PRL 8-53 shortly. I will probably give it a try next month. I will probably order the NA-Semax around that time too. I will try PRL 8-53 solo though before I start stacking.
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Let me know B4 you order the prl man.
 
Did you get a lot of stimulation from the PRL-853? I'm interested but it's expensive. I saw the stack you listed up there. I've got NA semax and floromodafanil at home. Semax is kinda stimulating, I like how clean it feels, but floromodafanil is really simulating and I don't honestly like it that much. Sub 75mg doesn't really do anything and after 100mg I feel it but not enough, 125mg and my hands start to jitter a lot. It always felt like dirty Adderall. I'd be interested in this stuff if it's not crazy stimulating and makes my hands shake. Hence me asking you guys before I spend a hundred bucks!
 
sespress said:
Did you get a lot of stimulation from the PRL-853? I'm interested but it's expensive. I saw the stack you listed up there. I've got NA semax and floromodafanil at home. Semax is kinda stimulating, I like how clean it feels, but floromodafanil is really simulating and I don't honestly like it that much. Sub 75mg doesn't really do anything and after 100mg I feel it but not enough, 125mg and my hands start to jitter a lot. It always felt like dirty Adderall. I'd be interested in this stuff if it's not crazy stimulating and makes my hands shake. Hence me asking you guys before I spend a hundred bucks!
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No stimulation from PRL853 at all. Also it's no where near $100.
 
No, P21 is acutely slightly sedating. That's why most people stack it with NASemaxA as do I. I don't want to comment on the long term effects yet because it's only been a couple of weeks but I'll write more after 6 weeks.
 
Hyperfluxe said:
No, P21 is acutely slightly sedating. That's why most people stack it with NASemaxA as do I. I don't want to comment on the long term effects yet because it's only been a couple of weeks but I'll write more after 6 weeks.
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Cool, appreciate it.
 
ELROCK said:
Do you find p21 stimulating? Most don't report any stimulation, but some people mention a slight stimulation.
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I have not used it but might pu to try in March.

Hyperfluxe said:
No, P21 is acutely slightly sedating. That's why most people stack it with NASemaxA as do I. I don't want to comment on the long term effects yet because it's only been a couple of weeks but I'll write more after 6 weeks.
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What have you noticed from the p21 so far?
 
I'll plan on getting some prl, na-selank amidate, and evomuse clearedge. How does that stack sound? Also anyone with a discount code please PM me


Also would centrophenoxine be worth adding to that
 
rtmilburn said:
I'll plan on getting some prl, na-selank amidate, and evomuse clearedge. How does that stack sound? Also anyone with a discount code please PM me


Also would centrophenoxine be worth adding to that
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Sounds like a fantastic stack! I have 3 bottles of CE coming and will be ordering PRL 8-53 soon so I may be doing the same stack eventually. With that said you really need to give each one their own run solo first. Even if you just give it 2 week (3 weeks would be better) each solo to get an idea how it's working for you. Then start stacking, adding and subtracting what works for you.
 
ELROCK said:
Sounds like a fantastic stack! I have 3 bottles of CE coming and will be ordering PRL 8-53 soon so I may be doing the same stack eventually. With that said you really need to give each one their own run solo first. Even if you just give it 2 week (3 weeks would be better) each solo to get an idea how it's working for you. Then start stacking, adding and subtracting what works for you.
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This, try them solo first. Are you guys not concerned with the lack of studies and safety data on some of these ingredients? I could see the appeal of using them occasionally, but I'd be hesitant to use things like PRL regularly.
 
muscleupcrohn said:
This, try them solo first. Are you guys not concerned with the lack of studies and safety data on some of these ingredients? I could see the appeal of using them occasionally, but I'd be hesitant to use things like PRL regularly.
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I have read how PRL seems to have acute memory enhancement so I was thinking of taking it 3-4 days a week and see how it works in that type of use.
 
muscleupcrohn said:
This, try them solo first. Are you guys not concerned with the lack of studies and safety data on some of these ingredients? I could see the appeal of using them occasionally, but I'd be hesitant to use things like PRL regularly.
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With prl I'm kinda concerned but not with samex or selank I'm not at all they are studied enough for me as for prl ya I agree it's not studied enough to determine safety at all
 
I'm assuming If it's sedative you must not get that tired with the Semax-NA in there that you can't concentrate. How much semax to cancel that effect out.
 
ELROCK said:
Sounds like a fantastic stack! I have 3 bottles of CE coming and will be ordering PRL 8-53 soon so I may be doing the same stack eventually. With that said you really need to give each one their own run solo first. Even if you just give it 2 week (3 weeks would be better) each solo to get an idea how it's working for you. Then start stacking, adding and subtracting what works for you.
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Planning on it! Think selank or samex would be better? I do have depression and anxiety and Selank seems to be better option for that but samex as also showed promise with this too
 
ELROCK said:
I have read how PRL seems to have acute memory enhancement so I was thinking of taking it 3-4 days a week and see how it works in that type of use.
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I am using PRL 4 days a week.

sespress said:
I'm assuming If it's sedative you must not get that tired with the Semax-NA in there that you can't concentrate. How much semax to cancel that effect out.
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Semax NA for me is not sedating.
 
rtmilburn said:
Planning on it! Think selank or samex would be better? I do have depression and anxiety and Selank seems to be better option for that but samex as also showed promise with this too
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I prefer Semax over Selank, but I haven't had as much time with Selank. I have only tried the normal Selank and I have only used it 5 times now. Selank is very calming for me. I have used it on a couple occasions where I was very stressed or when I took stims too late in the day. It seems to work very well for those purposes by calming me immediately (within 15 mins) down.
 
muscleupcrohn said:
This, try them solo first. Are you guys not concerned with the lack of studies and safety data on some of these ingredients? I could see the appeal of using them occasionally, but I'd be hesitant to use things like PRL regularly.
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As far as concerns on lack of studies goes, I can only answer for myself. In my current situation these forms of nootropics and brain hacking advantages are worth it for me. It is definitely going to be very individualized though and in many cases the risks aren't worth the reward. Personally, I own a small medical company that is on the break of becoming very large or about to fail. My performance in the next couple of years are really going to determine which way things will go. I have a lot riding on my career and many others relying on us prevailing. At this point in my life any brain boost is more than welcomed. Plus, it also helps that I think Semax is a very safe noot.
 
ELROCK said:
As far as concerns on lack of studies goes, I can only answer for myself. In my current situation these forms of nootropics and brain hacking advantages are worth it for me. It is definitely going to be very individualized though and in many cases the risks aren't worth the reward. Personally, I own a small medical company that is on the break of becoming very large or about to fail. My performance in the next couple of years are really going to determine which way things will go. I have a lot riding on my career and many others relying on us prevailing. At this point in my life any brain boost is more than welcomed. Plus, it also helps that I think Semax is a very safe noot.
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Good response, it's all about risk vs reward I suppose. I was more talking about PRL than the others.
 
Selank I haven't even tried yet. Thought about it this check and ended up getting the Semax-NA instead.

I should try both PRL and selank sometime, maybe in two weeks.
 
Ok I just got AZOTH in today. 10 servings for $22.50 plus shipping. I will use it Monday and Thursday. Review will be posted Friday.
 
Tried my first dose of PRL 8-53 this morning. I took 8 mg sublingually with a cup of black coffee. The numb tongue and gums reminded me of something else I once tried in college lol

I won't be giving my opinion on the experience until I have used it for a few weeks (3-4x a week). I will probably start a new thread for this stuff because I feel it could be pretty valuable.

Something else to add is that I ordered the NA-Semax with the PRL 8-53 so I can give each Semax version their own fair run. I am not sure when I will start that, but I will update this thread when I get to it.
 
Na-semax is amazing stuff. I've been using it semi daily. I still wonder what effects it may have on cortisol since it mimics ACTH. I happen to be on a run with Peptides which already boost cortisol so I've put in some super 7 and super 11. I plan on getting bloods done just out of curiosity

Does anyone have any input on the cortisol bit?
 
JohnP. said:
Ok I just got AZOTH in today. 10 servings for $22.50 plus shipping. I will use it Monday and Thursday. Review will be posted Friday.
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Interested to hear your thoughts on this...looking at the formula I think 2 caps would be more than enough for me personally
 
carguy123 said:
Interested to hear your thoughts on this...looking at the formula I think 2 caps would be more than enough for me personally
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Meh, at that point you may as well just use standalone phenylpiracetam, Noopept, and DMHA or your exotic stimulant of choice, as at 2 caps, most of the rest of the formula is underdosed.
 
muscleupcrohn said:
Meh, at that point you may as well just use standalone phenylpiracetam, Noopept, and DMHA or your exotic stimulant of choice, as at 2 caps, most of the rest of the formula is underdosed.
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Good point, just took a harder look now at the formula and agree with you
 
carguy123 said:
Interested to hear your thoughts on this...looking at the formula I think 2 caps would be more than enough for me personally
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Today was the 2nd time I used it. I will post my thoughts on it tomorrow.

muscleupcrohn said:
Meh, at that point you may as well just use standalone phenylpiracetam, Noopept, and DMHA or your exotic stimulant of choice, as at 2 caps, most of the rest of the formula is underdosed.
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That basically goes without saying for every single supplement


carguy123 said:
Good point, just took a harder look now at the formula and agree with you
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If you want, PM me your addy and I'll send you 2 day worth-6 caps.
 
Any update? I'm trailing in this discussion I've just ordered some PRL and I ordered the Semax-NA a week or two after you all brought it up so I didn't get a chance to chat about it much.
 
sespress said:
Any update? I'm trailing in this discussion I've just ordered some PRL and I ordered the Semax-NA a week or two after you all brought it up so I didn't get a chance to chat about it much.
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Feel free to discuss all you want in this thread man. I have been enjoying the NA-Semax quite a bit! Personally, I like all 3 versions of Semax and don't really notice much of a different between them. I would use any and all of them again. I will purchase whichever is on sale ATM. What are your thoughts on Semax?
 
Haven't had a chance to try the others just yet but I am a big fan of the NA-Semax. I just killed another bottle though, wish it wasn't as pricey or went a little further. Helps me focus a lot and is a better pick me up in the AM then a big glass of coffee.
 
sespress said:
Haven't had a chance to try the others just yet but I am a big fan of the NA-Semax. I just killed another bottle though, wish it wasn't as pricey or went a little further. Helps me focus a lot and is a better pick me up in the AM then a big glass of coffee.
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Today was my first day of adding 12 mg PRL 8-53 (6 day taking, but not on consecutive days) with (2 spays) NA-Semax (plus 1 coffee) and it made for a pretty great day! Since this is the first day of the stack it could very well just be placebo, but definitely great verbal recall, verbal fluency and mental clarity. I just felt on point all day!

I will start a PRL 8-53 thread on here soon.

Edit: corrected the PRL 8-53 dose. It was 12 mg today not my 10 mg usual dose.
 
You know my general feelings on Semax-NA are colored by the fact that I'm on various Peptides and Epistane and Trestolone. I still feel an immediate bump up but I'm kinda yoked 24/7 right now if you know what I mean
 
ELROCK said:
Too much Noopept in there for me!
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This, and going less than the full serving gives you too little of other ingredients. Their whole "we use a bigger dose because it has worse bioavailability orally than sublingually" thing doesn't really make much sense when there are studies showing it works with these doses orally; I don't see a need to dose it nearly that high.
 
sespress said:
You know my general feelings on Semax-NA are colored by the fact that I'm on various Peptides and Epistane and Trestolone. I still feel an immediate bump up but I'm kinda yoked 24/7 right now if you know what I mean
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I think the NA-Semax seems the most noticeable for me. I get the same effects (increase in productivity, mental clarity, refreshed feel and slight focus) the other two versions just slightly more pronounced.
 
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