Innova Pharm SR9009
- Thread starter CJNator
- Start date
jbryand101b
Banned
Has pretty much zero oral bioavailability.
Companies selling it are either ripping you off, or selling something else as sr9009
Companies selling it are either ripping you off, or selling something else as sr9009
jbryand101b
Banned
Believe what you want. We've been spending hours reading published studies on it. If it was orally useable to any degree, it would already be bottled an selling from ol UK
But we don't want to sell fairy dust with some low doses of steroids in it
But we don't want to sell fairy dust with some low doses of steroids in it
jbryand101b
Banned
The IV and oral DMPK profiles of compounds 3, 4, 10, 16, and 23 were evaluated in a 1 mg/Kg cassette dose experiment in C57Bl/6 mice.
Four of the compounds demonstrated essentially identical profiles with short half-lives, high clearance, and low oral bioavailability. Compound 4 (GSK2945) was differentiated from the group with a longer half-life of 2.0 h and an oral bioavailability of 23%, despite the higher cLogP of the compound (Table 2 and Supporting Information Figure 4).
[...]
The remaining four compounds (3, 10, 16, 23) would be suitable for acute time-of-day dosing by injection where short exposure of the compound at meaningful levels in desired
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Sr9009 is #3
Even the most promising #4 only had 2hr half life an oral bioavailability of 23%.
So sr9009 is even less.
1mg/kg
So a 150lb person taking 150mg of the promising compound at 23% would only get you around 34mg to last a couple hours then you'd want to dose another 150...
With sr9009, you'd get even less, with less time in the system
Invalid Link Removed
In case you want to read the 112 page study
.
Four of the compounds demonstrated essentially identical profiles with short half-lives, high clearance, and low oral bioavailability. Compound 4 (GSK2945) was differentiated from the group with a longer half-life of 2.0 h and an oral bioavailability of 23%, despite the higher cLogP of the compound (Table 2 and Supporting Information Figure 4).
[...]
The remaining four compounds (3, 10, 16, 23) would be suitable for acute time-of-day dosing by injection where short exposure of the compound at meaningful levels in desired
-------
Sr9009 is #3
Even the most promising #4 only had 2hr half life an oral bioavailability of 23%.
So sr9009 is even less.
1mg/kg
So a 150lb person taking 150mg of the promising compound at 23% would only get you around 34mg to last a couple hours then you'd want to dose another 150...
With sr9009, you'd get even less, with less time in the system
Invalid Link Removed
In case you want to read the 112 page study
.
Comeuppance
Member
That would explain why I've gotten basically nothing out of the SR9009 suspension I picked up from Ceretropic. What an expensive waste...
I'm guessing the favored route is going to be pinning or TD, and I have heard OL is working on SR9009, which makes me think they're going to release a TD of it if the oral bioavailability is so low.
I'm guessing the favored route is going to be pinning or TD, and I have heard OL is working on SR9009, which makes me think they're going to release a TD of it if the oral bioavailability is so low.
yates84
Well-known member
We will all know soon...
jbryand101b
Banned
This is what's been keeping us up at night lol