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YOHIMBINE HCL and AGMATINE SULFATE interaction??? science bros get in

drewdunkin199

New member
hey guys i have 2 questions regarding Agmatine Sulfate and Yohimbine



QUESTION 1:
yohimbine works by de-activating the the alpha a2 enzyme (stubborn fat) fat cells receptor.. which allows for easier oxidation of said stubborn fat stores.
Agmatine Sulfate (an amazing nootropic/pump) works by inhibiting the build of of lactid acid,, but it also activates the apha a2 fat receptor that holds on to stubborn fat.

i know that yohimbine has a acute response but also builds up in your system and has a substantial half life.
does agmatine sulfate build in your system as well???

could i take yohimbine pre fasted cardio,,and then agmatine sulfate later before bed, or would the agmatine sulfate build up in my system and inhibit the yohimbine from deactivating the apha-a2 fat receptor??


QUESTION 2: (an easy one)

I know that elevated insulin renders yohimbine ineffective, which is why it must be utilized in a fasted state.
is it known, or can it be figured out how much of an insulin spike would render yohimbine ineffective??

For instance i have a 200mg caffine tab that i would like to take with my yohimbine, but its is suspended a sugar tab.
could small amount of sugar/carb from the tab casue an acute enough insulin response to disable the yohimbine, or is this a case specific thing as everyone has a differing level of insulin sensitivity??
 
Yohimbe half life is short, very short.

If you're worried, dose the yohimbine pre-cardio and then Agmatine either pre-workout, pre-meals, or pre-bed.

If dosing yohimbine pre-cardio/exercise, I wouldn't worry about the small amount from the sugar/carb tablet.
 
Yea I would suggest that to. Yohimbine works well pre cardio and agmatine will give you good pump and blood flow pre workout.
 
Don't overthink it
Your caffeine tab won't render Y useless, certainly not right before cardio which will blunt insulin release hard.

It's not as simple as looking at it activating or deactivating the receptor, i recall is being a more complex pathway than this

Also plenty of us have used pres with them combined (like Enhanced) and it worked damn well.
 
Coop has posted on this before, but don't worry about it. The half life of Agmatine (not talking CNS half-life) is so short it won't blunt the effects of yohimbine significantly.
 
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