The scientists recruited 17 resistance-trained males (23±1yrs; 13.1±1.5% body fat) and randomly assigned them to ingest either 330mg/day 3b-hydroxy-5a-androst-1-en-17-one (PH; n=9) that were "enhanced" with 50mg of 6,7,-dihydrobergamottin, a grapefruit flavenol member of the furanocoumarin family that inhibits cytochrome P450-34A (Edwards. 1996), or 330mg/day plain maltodextrin (PLA; n=8). During the following 4 weeks, the subjects participated in a 16 session of structured resistance-training.
The training plans were hypertrophy specific and personalized. It is thus not really surprising that all subjects gained a significant amount of lean mass. What is surprising, though is how pronounced the inter-group differences were.
While the "1-Andro cycle" lead to significant increases in lean body mass 6.3±1.2%, decreased the total body fat mass by 24.6±7.1%, and increased the back squat 1-RM and average strength by 14.3±1.5% and 12.8±1.1%, respectively, the participants who were "on sugar" experienced only minor changes in body composition: 0.5±0.8% increases in lean mass and a 9.5±3.6% reduction in body fat. Needless to say that these changes, as well as the increased back squat 1-RM and average strength of 5.7±1.7% and 5.9±1.7% were also statistically different from the pronounced gains in the "1-Andro" group. In fact, they look pretty much like the almost frustatringly slow, but persistent gains you'd expect to see in already highly trained subjects within only 4 weeks (Note: The subjects in the placebo groups, i.e. the "low gainers", had 2 years less training (4.5y) experience than the high gainers in the "1-Andro group" with their 6.3y of resistance training history).
