low dose naltrexone ?

[sprintsss]

anyone has any experience with LDN?

 

[koi1214]

http://www.nlm.nih.gov/medlineplus/druginfo/meds/a685041.html

 

[sprintsss]

http://www.nlm.nih.gov/medlineplus/druginfo/meds/a685041.html

one of the most exciting aspects of LDN is the low reported incidence of adverse side effects. We have not seen incidences of ulcers, renal insufficiency, interference with warfarin and other common medications, increased heart attack or clotting risk, or other problems that can be seen with nonsteroidal anti-inflammatory drugs. We have observed no cases of severe adverse events in our research, and none have been reported from other laboratories. We have observed no withdrawal symptoms when LDN treatment is stopped, and withdrawal is not a known effect of treatment discontinuance [46]. However, the complete sample size of all LDN trials combined is still quite small and thus clinically useful data and experience are limited.

Side effects of LDN treatment are mild. In our research, participants have rated LDN as slightly more tolerable than placebo (91.0 versus 89.5*%, not significant). The most common side effect we have observed is the reporting of more vivid dreams, which is seen in approximately 37*% of the participants. In a minority of cases, patients report nightmares. As a side effect, vivid dreams develop rapidly (as soon as the first dosing) and decrease over time. It is unclear what mechanism may drive increased vividness of dreams. Individuals generally self-report increased effectiveness of sleep, so it is unlikely that the vivid dreams represent an adverse disruption of normal sleep patterns. It is important to note that increased vividness of dreams is also the most commonly reported side effect during placebo administration, so some cases may be driven by expectancy.

The frequency of headaches when taking LDN was slightly higher than during placebo administration, though more participants will need to be assessed in order to determine the statistical significance of the difference. Spontaneous headaches are common in individuals with fibromyalgia and frequently appeared in all stages of the clinical trials.

While not observed in research studies, some physicians have anecdotally reported anxiety and tachycardia as adverse reactions to LDN. As anxiety is a known symptom of opioid withdrawal, it is possible that some individuals would experience anxiety due to blockade of endogenous opioids. Further observation will need to be carried out to determine how common this adverse event is and how to best manage it.

For individuals without severe hepatic disease, there does not appear to be any need to frequently monitor hepatic function. Even at much larger dosages, naltrexone does not significantly change hepatic enzyme activity [47]. We have not observed any toxicity issues with chronic use.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/

 

[sprintsss]

http://www.nlm.nih.gov/medlineplus/druginfo/meds/a685041.html

For more information

http://www.lowdosenaltrexone.org/

I'm asking for the people who go thru chronic fatigue, autoimmune diseases and such who are trying to live active lifestyles

 

[koi1214]

For more information

http://www.lowdosenaltrexone.org/

I'm asking for the people who go thru chronic fatigue, autoimmune diseases and such who are trying to live active lifestyles

Okay good luck.

 

[sprintsss]

Okay good luck.

The side effects page you posted is for the full dosage (50mg-100mg) which is geared for alcohol abuse and other treatment s

I'm talking about 1mg - 4.5mg at most

 

[sprintsss]

Okay good luck.

Clinical trails for LDN

http://www.lowdosenaltrexone.org/ldn_trials.htm

Too long to post on here