My advice is to start out at a low dose... say 50mg/ed to assess the side effects. I've run it up to 150mg/ed and the only real side I got was the night sweats. It effects some people differently though. It is a substance that is known for causing roid rage... severe in some cases. Also got to watch the BP close. I strongly suggest to run test with it at at least 250mg/week. I usually run it higher than that, but there are several threads here now that say more tren sides kick in if you run high dose of test with it.. they are suggesting low dose. Use the search function here, tren is something you really want to research before you jump in. I also strongly suggest starting out with Tren Ace, that way if you have a problem with it, it clears your system in about 24-36 hours unlike Tren E which can take weeks to clear.