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Bromocriptine and leptin

ssbackwards

Well-known member
I was reading lyle mcdonalds book on bromocriptine and leptin saying that due to it being a Da2 agonist and partion D1 agonist its potential effects on dieting are mediated my it "leptin mimicking" properties,

now with this said i would assume for dieting individuals, taking 2.5mf for 2 days every 4 or 5 days would work well in cycles of 2 weeks at a time, then the last cycle having a carb meal since messing with the dopaminegic system can be potentially harmful in terms of

LH and testosterone, poor prolactin estrogen balance etc (Seth roberts book anabolic pharmacology) and in one of his threads.

Can you give some insight for those who possibly are looking into dropping more body fat, consisten use of this anchillary, and potential/harmful effects of everyday use or spuratic use?

Thanks
 
bromo will destroy your hunger, i strugged getting in 1000 cals, i would throw up 3xtime a day constantly i dropped like 5% on it with epi and other goodies
 
rochabp said:
bromo will destroy your hunger, i strugged getting in 1000 cals, i would throw up 3xtime a day constantly i dropped like 5% on it with epi and other goodies
Click to expand...

My god that sounds scary. What was the delivery system for bromocriptine? Inj? Or can you actually orally ingest it?
 
oral, never heard of injecction...yeah its horrible man you feel like **** but youll loose a lot of weight with out trying
 
I've been looking at it and researching for the past week

I'll try it soon, purpose for me would be its ability of increasing leptin
and rebalancing hormones (due to extreme and prolonged diet),
restoring/increasing metabolism.
It also have several other benefits..
 
im seeing a trend of people using it however, L dopa may work the same if it acts on d2r. if not then i dont know.
?
Rocha, did you experience exotic behavoir? like more risky, more addictive etc?

another issue with things like dopamine agonist is the way it increases histamine receptors much like clen would, so an anti histamine may be in order to keep effectiveness.

its actually funny studies show it decreases circadian leptin in obese individuals probably due to resistance, by possible allowing leptin to pass the BBB to reduce hunger and increase thermogenesis. but whats funny is Prolactin is needed in neogenesis of beta cells of the pancreas. now the issue is lower prolactin injections proverd to be more beneficial then higher prolactin levels. go figure.

also prolactin INCREASES in pregnant women. Theres a bunch of information out there.

Bromocriptin blocks somatostatin, so maybe pre bed is best bet to exert its effect.
 
no nothing at all i expected that too but no i did not infact i experience the opposite, like i didnt need anything or anyone
 
rochabp said:
no nothing at all i expected that too but no i did not infact i experience the opposite, like i didnt need anything or anyone
Click to expand...

Wow interesting indeed.
Sparked my interest. Lol
 
MAYBE ill try it on a bulk with tren and test and adex and igf1. for 8 weeks

may be worth a shot with IF based keto diet (3000-4000 cals) keep off fat, block somatostatin.
 
you i consider myself mentally tough i dont complain too often about supps and sides like on sd i didnt complain about all the horrible sides i just took it but man if there was ever a time to complain about something giving you sides it was on bromo
 
what time of the day did u take it, im thinking right before bed, so by morning its not too too bad. although i assume a halflife of 2 days with this
 
ssbackwards said:
what time of the day did u take it, im thinking right before bed, so by morning its not too too bad. although i assume a halflife of 2 days with this
Click to expand...
it didnt matter but i took it in morning and at night split up
 
actaully i think 2.5 but at times id go up to 5
 
hmm wonder what the docs views on this are,

coming off did you have problem with prolactin based sides? rebound in weight gain?
 
mattrag said:
Hmm. I see. That can be quite a goo reason to stay away from this lol.
Click to expand...
id say so...but ive been using prami and noticed that if taken high enough it will cause the exact same sides as bromo. again you have to dose higher though. at the normal dose its fine...np
 
i dont get your question
 
u switched bromo for prami?

not the same thing right??? so in that case are pramis effects different then bromos in terms of weight loss appetite etc.
 
ssbackwards said:
u switched bromo for prami?

not the same thing right??? so in that case are pramis effects different then bromos in terms of weight loss appetite etc.
Click to expand...
yeah prami gives no sides, for the most part, it does however make me sleepy as isht, plus it has the added benefit of increasing hgh a significant amount, which maybe explain the increase in hunger at times but at other times hunger isnt good.
 
rochabp said:
yeah prami gives no sides, for the most part, it does however make me sleepy as isht, plus it has the added benefit of increasing hgh a significant amount, which maybe explain the increase in hunger at times but at other times hunger isnt good.
Click to expand...

so subbin prami for bromo is good idea..

hmmm ill research more
 
Hmmm that'd be interesting... Unless you're taking prami to fight if prolactin on a tren cycle and not using it for it's bromocriptine effects on leptin.
 
yeah for prolactin its better but if you tryin to use it for cutting or starving purposes bromo will do.
 
wow... this stuff sounds awful... why not just take a tone of thyroid hormones and run around all day to burn fat????

I couldnt even stand the sides I got from Clen, felt like crap, my body ached all over and I had a constant headache.... I cant imagine taking anything that does the things your mentioning there rochabp...
 
Bromo has been around for 30 years, everyone reacts differently to different stuff,
there's people having bad sides with freakin' aspirin..
McDonald book explains in details everything about it, I decided to try it after reading it,
researching and speaking with people, while I'm still researching (out of curiosity mostly)
there's no other way to see what can do for you. On paper looks very interesting for where
I am right now

Sides get noticeable (according to the script) with much higher dose, at 2.5/5mg
after the first few days there shouldn't be any. With that said, the advice is to start low
of course and reach the right dose progressively
 
Sourdough said:
wow... this stuff sounds awful... why not just take a tone of thyroid hormones and run around all day to burn fat????

I couldnt even stand the sides I got from Clen, felt like crap, my body ached all over and I had a constant headache.... I cant imagine taking anything that does the things your mentioning there rochabp...
Click to expand...
clen sides are nothing compared to bromo sides in my experience no joke take clan sides and multiply by a good 5 or 6 times (noexagggeration at all)

bdcc said:
Haha! It was worth it though, right? ;)
Click to expand...
haha, no way jose
 
rochabp said:
clen sides are nothing compared to bromo sides in my experience no joke take clan sides and multiply by a good 5 or 6 times (noexagggeration at all)
Click to expand...

yup... never touching that stuff.... noooooo spank you...
 
ssbackwards said:
I was reading lyle mcdonalds book on bromocriptine and leptin saying that due to it being a Da2 agonist and partion D1 agonist its potential effects on dieting are mediated my it "leptin mimicking" properties, now with this said i would assume for dieting individuals, taking 2.5mf for 2 days every 4 or 5 days would work well in cycles of 2 weeks at a time, then the last cycle having a carb meal since messing with the dopaminegic system can be potentially harmful in terms of LH and testosterone, poor prolactin estrogen balance etc (Seth roberts book anabolic pharmacology) and in one of his threads.
Click to expand...

I have, unfortunately not been privy to McDonald's work outside of ketogenic variants ("The Ketogenic Diet" / "UD 2.0" / "Quick Fat Loss Handbook" or whatever the last one is called); but I am sure it's well written and thought-provoking. One might even say he was WAY AHEAD of his time; the quick-acting variant (Cycloset) was approved in the treatment of type 2 Diabetics after unequivocal data suggesting Bromocriptine improves glycemic control and glucose tolerance in obese type 2 diabetic patients. Both reductions in fasting and postprandial plasma glucose levels appear to contribute to the improvement in glucose tolerance. The bromocriptine-induced improvement in glycemic control is associated with enhanced maximally stimulated insulin-mediated glucose disposal. Keep in mind that despite all of this; body comp remained the same...so one must ask why they truly want to use it.

Now, I am afraid that studies trying to illicit what exact mechanism is on hand have fallen short of task except in cases of obesity, namely those related to hyperprolactinemia. Bromocriptine is interesting in that there appears a transient increase in leptin in this scenario followed by a lowering of leptin (probably a result of lower BF); similarly, circadian levels of leptin actually FALL as well in obese subjects in response to prolactin.

What does this mean? There's a positive response for dopamine agonism and it could prove very quintessential for those harboring low serum gonadotropins or high prolactin and subsequent low gonadotropins; but we cannot generalize to the "normal" population, although it is thought-provoking, it simply has NOT translated itself well to the real world. If body comp is impacted, and that's why I would anticipate you'd use it in the first place, then it's likely that you'd be lowering leptin secondary to body comp changes...at least to some degree, if it does...in effect work completely how we hypothesize. I just don't know if it's worth it for the side effects many get with effective dosing; I certainly don't know if it's worth it in the long run.

I attempted to use the quick-acting myself (Cycloset); but had far too many sides as I ramped up the dose. In 3 months, saw no body comp change from it...so I aborted the therapy.




Can you give some insight for those who possibly are looking into dropping more body fat, consisten use of this anchillary, and potential/harmful effects of everyday use or spuratic use?

Thanks
Click to expand...

Predominantly GI and autonomic.

I was overtly nauseous; my blood pressure and blood sugar dropped low (SBP in the 90s; Blood sugar 40-50 mg/dl); I was very light-headed secondary to autonomic pressure versus blood sugar was unbeknownst to me.

I would ultimately say ... skip it.


D_
 
dinoiii said:
I have, unfortunately not been privy to McDonald's work outside of ketogenic variants ("The Ketogenic Diet" / "UD 2.0" / "Quick Fat Loss Handbook" or whatever the last one is called); but I am sure it's well written and thought-provoking. One might even say he was WAY AHEAD of his time; the quick-acting variant (Cycloset) was approved in the treatment of type 2 Diabetics after unequivocal data suggesting Bromocriptine improves glycemic control and glucose tolerance in obese type 2 diabetic patients. Both reductions in fasting and postprandial plasma glucose levels appear to contribute to the improvement in glucose tolerance. The bromocriptine-induced improvement in glycemic control is associated with enhanced maximally stimulated insulin-mediated glucose disposal. Keep in mind that despite all of this; body comp remained the same...so one must ask why they truly want to use it.

Now, I am afraid that studies trying to illicit what exact mechanism is on hand have fallen short of task except in cases of obesity, namely those related to hyperprolactinemia. Bromocriptine is interesting in that there appears a transient increase in leptin in this scenario followed by a lowering of leptin (probably a result of lower BF); similarly, circadian levels of leptin actually FALL as well in obese subjects in response to prolactin.

What does this mean? There's a positive response for dopamine agonism and it could prove very quintessential for those harboring low serum gonadotropins or high prolactin and subsequent low gonadotropins; but we cannot generalize to the "normal" population, although it is thought-provoking, it simply has NOT translated itself well to the real world. If body comp is impacted, and that's why I would anticipate you'd use it in the first place, then it's likely that you'd be lowering leptin secondary to body comp changes...at least to some degree, if it does...in effect work completely how we hypothesize. I just don't know if it's worth it for the side effects many get with effective dosing; I certainly don't know if it's worth it in the long run.

I attempted to use the quick-acting myself (Cycloset); but had far too many sides as I ramped up the dose. In 3 months, saw no body comp change from it...so I aborted the therapy.






Predominantly GI and autonomic.

I was overtly nauseous; my blood pressure and blood sugar dropped low (SBP in the 90s; Blood sugar 40-50 mg/dl); I was very light-headed secondary to autonomic pressure versus blood sugar was unbeknownst to me.

I would ultimately say ... skip it.


D_
Click to expand...

Doc, McDonald describes in the mentioned book how injection of leptin failed to be effective (even tho' there's an addendum that states
further experiments got better results etc..)

So, is there ANY way to boost leptin/the action leptin has on metabolism (let's just say, avoiding the body from going into starvation-mode, slow metabolism and getting slower at burning fats *for someone with 5%BF*)?
Aside from the refeed protocol (assuming that actually boosts leptin..)
 
ssbackwards said:
im seeing a trend of people using it however, L dopa may work the same if it acts on d2r. if not then i dont know.
?
Rocha, did you experience exotic behavoir? like more risky, more addictive etc?

another issue with things like dopamine agonist is the way it increases histamine receptors much like clen would, so an anti histamine may be in order to keep effectiveness.

its actually funny studies show it decreases circadian leptin in obese individuals probably due to resistance, by possible allowing leptin to pass the BBB to reduce hunger and increase thermogenesis. but whats funny is Prolactin is needed in neogenesis of beta cells of the pancreas. now the issue is lower prolactin injections proverd to be more beneficial then higher prolactin levels. go figure.

also prolactin INCREASES in pregnant women. Theres a bunch of information out there.

Bromocriptin blocks somatostatin, so maybe pre bed is best bet to exert its effect.
Click to expand...

bumping the above for you doc as well as this below

now with this said i would assume for dieting individuals, taking 2.5mf for 2 days every 4 or 5 days would work well in cycles of 2 weeks at a time, then the last cycle having a carb meal since messing with the dopaminegic system can be potentially harmful in terms of

LH and testosterone, poor prolactin estrogen balance etc (Seth roberts book anabolic pharmacology) and in one of his threads.

 
AutoKal47 said:
Doc, McDonald describes in the mentioned book how injection of leptin failed to be effective (even tho' there's an addendum that states
further experiments got better results etc..)

So, is there ANY way to boost leptin/the action leptin has on metabolism (let's just say, avoiding the body from going into starvation-mode, slow metabolism and getting slower at burning fats *for someone with 5%BF*)?
Aside from the refeed protocol (assuming that actually boosts leptin..)
Click to expand...

If I remember correctly, they injected obese people w/ leptin with failed results. They discovered that some obese people actually had abnormally high levels of leptin and administering additional leptin made no difference. This discovery showed that in some obese people the problem was not low leptin, but the body having no response to leptin leading to very high natural leptin levels.

The other issue w/ leptin injection therapy was that it was some $10,000 for each day to run, at least at that time.
 
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