Well I had what I thought was gyno a while back and I researced and researched, I finally decided to go with letro, and I got it from a research site. Two and a half weeks in all symptoms were gone I lowered the dosage on my letro for the next week or so and stopped use all together. Since then I've had no flare ups and have run a dplex cycle and an mdrol cycle. With the tren I don't know how letro works with prolactin or progesterone. I would say research as much as u can and try to make an educated decision on what to use to combat it.