Here is my Take about Estradiol E2 I have been at this many yrs been on TRT over 30 yrs and after a time I got some bad ED, could not reach an Orgasm, had a lot of Anxiety even Panic Attacks and BPH for about 10 yrs. I lost my sex life needed to use a penis pump and ring to keep my wife happy. I started TRT in my late 30's by age 50 I lost my sex life and it was very high Estradiol E2 levels. The long and short of all this is when I got this back down after trying every thing you could think of. Arimidex worked to get this down. I took my being on .5 mgs everyday for 8 weeks to get levels down from >90 to 20 pg/ml the first thing to come back was. These involuntary nocturnal erections that appear during REM (Rapid Eye Movement) sleep I call this morning wood.
Then my ED was better but the worry about it staying up for sex would kill it at the time Cialis 20 mgs came out so my Dr. told me take this every 3 days it will help with this problem and you don't need to wait for a pill to work and it will help keep your BP down. This worked great so all was good for a time until the Arimidex started to let E2 rebound on me I could take 1 mg. in the morning and be to high by bedtime the longer I was on Arimidex the worse it got. And I gage my E2 levels by my morning wood if I don't feel I had it before I get out of bed I will check and see if I can get it up fast and it's good and hard. So if I drive my E2 down to low I can't get it up taking a pill so I stop Arimidex. If I can get it up but it takes longer and it's not a good one I know I am going to high on E2 and I would take more Arimidex.
I have yet to find a way to take Arimidex the same dose and keep my E2 in the best level. So now I take Aromasin and I find cutting up this small pill is a waste of time I do great taking the 25 mgs every 2 to 3 days it is the best med I ever tired for keeping E2 in check.
If one is on Clomid or any kind of SERM med you can't test Estradiol less your off it a good 4 to 6 weeks your labs will not be any good. I know men that were not able to jump start them selfs that do 12.5 mgs of Clomid every day to every 3 days one guy in the UK his levels went up to 14 nmol/L top of range is 9.7 so he is cutting back to 12.5 mgs of clomid ever 3 days from everyday. And gaging his E2 levels by his morning wood.