Anything that demonstrates vasoactive (constrictive) properties can attenuate the vasodilatory aspect "the pump". This can vary in people due to different reasons, but I would opt out of anything that demonstrates this unless it's warranted in your medication or supplement regimen.
GPLC has other effects outside the NOx upreguation (such as lactic acid mitigation), but that's one of its most evinced effects noted by users that you'll notice after use.
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