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DNP (2 4-dinitrophenol)

PGCL seems to work better, although it is newer and less is really known about it..

Anyone here tried both DNP and PGCL?
 
Right, but cataracts (and DNP-induced catarats specifically) are distinct from other visual impairments that also affect acuity. When people say "I have a hard time focusing on things more then 20' away" or other vague changes in acuity, all evidence says it's not the DNP. Cataracts from DNP are unique and identifiable. Let me quote Horner:


That's like the argument from the show "curb your entusiasm"-- "He has the <good>type of hodgkins". :D Dnp can cause cataracts. Cataracts affect visual acuity. Dnp has shown ill effects at smaller dosages than we even use for fatloss. It's a hit or miss compound as we've all pretty much pointed out. At the bottom of this post is an excerpt from a public health statement about dnp that has some interesting stuff in it..

I will say that I feel like a hypocrite with this topic because I have used and will use clen and t3, which on some boards get blasted as being too dangerous to mess with. I completely understand your stance on dnp. My only point is that there are people that will come here who won't take the time to research things the way most of us do. With this being something that CAN kill you somewhat easier or have more serious consequences than alot of the stuff we use, we shouldn't make light of it's dangers. And you are absolutely right, it can be safe and effective for some. It comes down to personal choice.


excerpt:
How can dinitrophenols affect my health?

Most of what we know about how DNP can affect your health comes from old reports by doctors who prescribed DNP to patients who wanted to lose weight. A person could even buy DNP at a drug store without a prescription. DNP has been banned by the U.S. Food and Drug Administration as a diet pill since 1938 because of the harmful effects that occurred in their patients, especially cataracts. Most of the ways that DNP can affect your health do not depend on how you are exposed or for how long. Some people who took DNP were harmed, while others were not, even though they took the same or higher doses. Although some people became ill after taking DNP for short periods, other people could take DNP for longer periods before becoming ill. This means that some people are more sensitive to the harmful effects of DNP than others. Brief or long-term exposure to DNP can cause increased basal metabolic rates (the rate that you use energy at complete rest); a feeling of warmth; sweating; weight loss; and increased heart rate, breathing rate, and body temperature. Some or all of these effects have occurred in some people after they swallowed doses as high as 46 milligrams of DNP per kilogram of their body weight per day (mg/kg/day) or doses as low as 1 mg/kg/day DNP. Some people who took doses of 2 mg/kg/day DNP or more for short or long periods experienced numbness in their hands and feet. Some people who swallowed doses of 6 mg DNP/kg/day for short periods or doses of 1 to 4 mg/kg/day DNP for long periods had a serious decrease of certain types of white blood cells that fight disease. Some people who swallowed doses of 1 to 4 mg/kg/day DNP for short or for long periods developed serious skin reactions that sometimes disappeared even while they were still being exposed. DNP caused cataracts in both eyes of some people who swallowed about 2 to 4 mg/kg/day DNP for short or long periods. This condition could lead to blindness in both eyes. If you breathe in, swallow, or have skin contact with large amounts of DNP, you may die. A few people have died after swallowing 3 to 46 mg/kg/day of DNP for short periods or doses as low as 1 to 4 mg/kg/day for long periods. Some workers who breathed in air containing 40 mg DNP per cubic meter of air (mg/m³) or more for long periods have also died.

The effects of DNP found in animals are similar to those in humans, except that the effects on feeling in the hands and feet, and on white blood cells were not found in animals. Cataracts also occurred in some types of animals that swallowed DNP.


Most of what we know about how DNP can affect your health comes from old reports by doctors who prescribed DNP to patients who wanted to lose weight. A person could even buy DNP at a drug store without a prescription. DNP has been banned by the U.S. Food and Drug Administration as a diet pill since 1938 because of the harmful effects that occurred in their patients, especially cataracts. Most of the ways that DNP can affect your health do not depend on how you are exposed or for how long. Some people who took DNP were harmed, while others were not, even though they took the same or higher doses. Although some people became ill after taking DNP for short periods, other people could take DNP for longer periods before becoming ill. This means that some people are more sensitive to the harmful effects of DNP than others. Brief or long-term exposure to DNP can cause increased basal metabolic rates (the rate that you use energy at complete rest); a feeling of warmth; sweating; weight loss; and increased heart rate, breathing rate, and body temperature. Some or all of these effects have occurred in some people after they swallowed doses as high as 46 milligrams of DNP per kilogram of their body weight per day (mg/kg/day) or doses as low as 1 mg/kg/day DNP. Some people who took doses of 2 mg/kg/day DNP or more for short or long periods experienced numbness in their hands and feet. Some people who swallowed doses of 6 mg DNP/kg/day for short periods or doses of 1 to 4 mg/kg/day DNP for long periods had a serious decrease of certain types of white blood cells that fight disease. Some people who swallowed doses of 1 to 4 mg/kg/day DNP for short or for long periods developed serious skin reactions that sometimes disappeared even while they were still being exposed. DNP caused cataracts in both eyes of some people who swallowed about 2 to 4 mg/kg/day DNP for short or long periods. This condition could lead to blindness in both eyes. If you breathe in, swallow, or have skin contact with large amounts of DNP, you may die. A few people have died after swallowing 3 to 46 mg/kg/day of DNP for short periods or doses as low as 1 to 4 mg/kg/day for long periods. Some workers who breathed in air containing 40 mg DNP per cubic meter of air (mg/m³) or more for long periods have also died.



We do not know whether DNP causes reproductive or birth defects or cancer in humans. One study in rats suggested that if DNP is swallowed during pregnancy or nursing, it may cause death in newborn babies. Two other studies in mice suggested that DNP did not have effects on the unborn infant. We do not know whether DNP causes cancer in animals.
 
I will say that I feel like a hypocrite with this topic because I have used and will use clen and t3, which on some boards get blasted as being too dangerous to mess with. I completely understand your stance on dnp. My only point is that there are people that will come here who won't take the time to research things the way most of us do. With this being something that CAN kill you somewhat easier or have more serious consequences than alot of the stuff we use, we shouldn't make light of it's dangers. And you are absolutely right, it can be safe and effective for some. It comes down to personal choice.
On that note, a lot of people also take clomid during post cycle therapy. This has a risk of cataracts. It's possible that tamoxifen does as well.
 
is 2 4-dinitrophenol available in the US as a research chemical like clen is? I would like to test it on a few rats to see which is better but dont know of a research site i can find it
 
is 2 4-dinitrophenol available in the US as a research chemical like clen is? I would like to test it on a few rats to see which is better but dont know of a research site i can find it

No, you can't buy it as a research chem. It is too dangerous for the average researcher. I think your rats should focus more on diet than weight loss drugs.
 
DNP was a compound used to aid in weight loss back in the approx 1940s. In the 1940s, some physicians prescribed the drug DNP (dinitrophenol) to help patients lose weight. This treatment was abandoned after several patients died.
DNP works by uncoupling the chemiosmotic machinery by making the lipid bilayer of the inner mitrochondrial membrane leaky to H+.Synthesis of fatty acid in adipose tissue requires cooperation of mitochondrial and cytoplasmic enzymes. Mitochondria release energy from food molecules and transform energy into useable form via the production of ATP. ATP is the primary carrier of energy within your cells, and most cells die quickly in the absence of it.

This will tell your body will need to create more energy than usual to keep up with the demands DNP is placing on it. In addition, it will have to use more of the food you take in to produce that much-needed energy, and less of that food to create and store fat.

This is just some of what I remember from reading my old biochemistry notes and some stuff I copied up here. There's more to it im sure online else where.

1%<died

I have also been researching about DNP. i had bookmarked several studies but I reformatted :-(
. Anyways I have been researching and reading about it for a good month already. I read the thread here. Invalid Link Removed

I think its the best DNP info you can find.

I also think it should be a sticky on this forum. We should also have a clen sticky here too. I am going to copy and paste and hopefully the mods will consider making it a sticky.
 
1%<died

I have also been researching about DNP. i had bookmarked several studies but I reformatted :-(
. Anyways I have been researching and reading about it for a good month already. I read the thread here. Invalid Link Removed

I think its the best DNP info you can find.

I also think it should be a sticky on this forum. We should also have a clen sticky here too. I am going to copy and paste and hopefully the mods will consider making it a sticky.



Wow this is good. Thanks. If anybody else is looking go to steriod forum then its a sticky. How to not F up DNP I second making this a sticky at least the actual post from the other forum. Thanks for your research and making it a easy click for me.
 
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