creatine into creatinine??
- Thread starter just93
- Start date
bigrobbierob
Active member
No.
That's dependant on the pH (the lower the pH the faster the degradation) and dependant on the temperature (the higher the temperature the faster the degradation). I've heard anywhere between 10 minutes and 6 hours (depending on conditions).
redemption79
Member
What are your intentions?
There's really nothing to worry about here...unless you are storing your creatine long term in water bottles.
Orig. posted by Patrick Arnold:
There's really nothing to worry about here...unless you are storing your creatine long term in water bottles.
Orig. posted by Patrick Arnold:
redemption79
Member
There are some studies that have surfaced recently showing CEE to convert to creatnine in the body at a higher rate than CM.
bigrobbierob
Active member
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Creatine ethyl ester rapidly degrades to creatinine in stomach acid. 1Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom. 2University of Northumbria, Sport Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne, United Kingdom.
Creatine ethyl ester (CEE) is a commercially available synthetic creatine that is now widely used in dietary supplements. It comprises of creatine with an ethyl group attached and this molecular configuration is reported to provide several advantages over creatine monohydrate (CM). The Medical Research Institute (CA, USA) claim that the CEE in their product (CE2) provides greater solubility in lipids, leading to improved absorption. Similarly San (San Corporation, CA, USA) claim that the CEE in their product (San CM2 Alpha) avoids the breakdown of creatine to creatinine in stomach acids. Ultimately it is claimed that CEE products provide greater absorption and efficacy than CM. To date, none of these claims have been evaluated by an independent, or university laboratory and no comparative data are available on CEE and CM. This study assessed the availability of creatine from three commercial creatine products during degradation in acidic conditions similar to those that occur in the stomach. They comprised of two products containing CEE (San CM2 Alpha and CE2) and commercially available CM (Creapure®). An independent laboratory, using testing guidelines recommended by the United States Pharmacopeia (USP), performed the analysis. Each product was incubated in 900ml of pH 1 HCL at 37± 1°C and samples where drawn at 5, 30 and 120 minutes. Creatine availability was assessed by immediately assaying for free creatine, CEE and the creatine breakdown product creatinine, using HPLC (UV). After 30 minutes incubation only 73% of the initial CEE present was available from CE2, while the amount of CEE available from San CM2 Alpha was even lower at only 62%. In contrast, more than 99% of the creatine remained available from the CM product. These reductions in CEE availability were accompanied by substantial creatinine formation, without the appearance of free creatine. After 120 minutes incubation 72% of the CEE was available from CE2 with only 11% available from San CM2 Alpha, while more than 99% of the creatine remained available from CM. CEE is claimed to provide several advantages over CM because of increased solubility and stability. In practice, the addition of the ethyl group to creatine actually reduces acid stability and accelerates its breakdown to creatinine. This substantially reduces creatine availability in its esterified form and as a consequence creatines such as San CM2 and CE2 are inferior to CM as a source of free creatine.
This research was presented at the 4th Annual International Society of Sports Nutrition Conference (Las Vegas, USA)
redemption79
Member
It's not really that simple. Nobody manufactured creatine with it being "useless" in mind. There is a lot to be learned about all alternative forms of creatine. There aren't any studies (that I know of) showing CEE's superiority over CM. Everything is based on CM's studys and a belief that CEE is more effectively absorbed.
Many people still swear CEE is the cat's meow. (i.e.the bees knees)
I like CM, but the jury is still out. There are many angles yet to be explored regarding CEE, Kre alk, and others. CEE isn't too appealing at this point though IMO.