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Furaz's effects on HDL

Whacked

Well-known member
Anyone know?
 
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William Llewellyn said:
It is being said that like furazabol, this new designer steroid lowers cholesterol and improves cardiovascular disease risk. An exact quote taken from product marketing is as follows, “FURAGUNO may be helpful in reducing cholesterol levels and could possibly play a preventive role with certain cardiovascular issues”. It is very important to make sure you know that this is actually not true. I am not necessarily going to fault the manufacturer for stating this. I can see where the information is coming from. It is based on a popular misconception about furazabol lowering cholesterol. And if furaguno is structurally similar to furazabol, it too must lower cholesterol, no?

Here is the problem. Furazabol was the subject of a series of investigations during the mid 1970’s, some reporting that the drug lowered serum cholesterol. Similar results were shown with other oral steroids around the same time, including the popular American steroid Anavar. It was soon established, however, that any lowering of total serum cholesterol with oral anabolic steroids was usually the result of suppressed HDL (good) cholesterol. It is now widely understood, of course, that ratio of good to bad cholesterol is generally more important to heart disease risk than total cholesterol. It is also firmly established that oral steroids tend to be particularly potent at increasing cardiovascular disease risk due to an altering of the hepatic management of cholesterol, shifting the HDL/LDL ratio in the wrong direction. The problem with furazabol is, it is hard to find modern studies on the drug showing its effects on HDL/LDL levels like we have with Anavar. The steroid-sleuths of modern day are left with an information gap. Upon investigation, one only finds these seemingly positive reports about lowering cholesterol. The myth of furazabol improving cholesterol was born, and unfortunately persists today.

The cholesterol-lowering myth about furazabol was much less dangerous when the drug was widely unavailable. You couldn’t find it, so it was simply a little bit of inaccurate information. But things have a way of changing, and today underground furazabol is making a comeback. Plus, we now have this “grey market” analog being sold with similar claims. I must emphasize again that they aren’t true. Furazabol use is expected to increase cardiovascular disease risk, not improve it. While Furaguno may be less potent in this regard due to the lack of c-17 methylation, it is likely to have a noticeable effect here. Expect that its use will result in a measurable suppression of HDL cholesterol levels, which may be accompanied by relatively stable or even elevated LDL (bad) cholesterol. Proceed with the same respect you would give other oral steroids, and most certainly do not take this if you have high cholesterol and are looking for an improvement.
 
Anyone know?

It actually doesn't have any positive effects on Cholesterol. That rumor stems from the fact that it lowers HDL (Good Cholesterol) just like most roids. Do a google search on "furazabol lowering cholesterol" and you'll see what I mean. Trust me if this stuff had a positive effect CVD, the pharm companies would be all over it.
 
Great info. Thanks.

Would running nolvadex or Clomid with 17-aa's improve the HDL levels?
 
I'm just throwing this out there because I ran across it when I was doing some searches. This is NOT a recommendation, I just found this study interesting. Yes, it is in mice.

Attenuation of tamoxifen-induced hepatotoxicity by taurine in mice.
Tabassum H, Rehman H, Banerjee BD, Raisuddin S, Parvez S.
Immunotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.

BACKGROUND: One of the most attractive approaches to disease prevention involves the use of natural antioxidants to protect tissue against toxic injury. We investigated the modulatory effects of exogenously administered taurine on the toxicity of the anticancer drug tamoxifen with special reference to protection against disruption of drug metabolizing and antioxidant enzymes in Swiss albino mice. METHODS: Male Swiss albino mice were divided into 4 groups. The extent of lipid peroxidation was evaluated in terms of thiobarbituric acid reactive substances formed. The following assays were performed in the hepatic tissue (a) antioxidant enzymes such as superoxide dismutase and catalase, (b) cytochrome P450 content, (c) glutathione-metabolizing enzymes such as glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose 6-phosphate dehydrogenase, and (d) low molecular weight antioxidants (reduced glutathione, ascorbic acid) and protein carbonyl content. RESULTS: Tamoxifen induced lipid peroxidation, protein carbonyl content and inhibited the enzymes of antioxidant defense system. It was also observed that the activities of antioxidant enzymes and glutathione-metabolizing enzymes were considerably stabilized in mice pretreated with taurine. CONCLUSION: Taurine protects the integrity of the hepatic tissue by stabilizing the reactive oxygen species mediated lipid peroxidation and protein carbonyl formation. Additionally taurine may prove to be efficacious as an antioxidant in tamoxifen-induced hepatotoxicity.

PMID: 16556438 [PubMed - indexed for MEDLINE]
 
I'm just throwing this out there because I ran across it when I was doing some searches. This is NOT a recommendation, I just found this study interesting. Yes, it is in mice.

Good stuff! Any idea on the dosage used?


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Good stuff! Any idea on the dosage used?


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2.3. Study design
Animals were divided in 4 groups and each consisted of 6–8 animals. TAM was administered intraperitoneally (i.p.) and taurine by gavage (per os, p.o.). Control animals (Group I) were administered normal saline p.o. for 10 days and a single i.p. injection of the same on the 9th day. TAM (50 mg/kg body weight) was given in a single dose on the 9th day of treatment (Group II). Taurine (100 mg/kg body weight) p.o. was administered for 10 consecutive days (Group III). Group IV (TAM + taurine) mice were given taurine treatment for 10 days and a single injection of TAM on the 9th day along with taurine. Dosing was done in such a way that all the animals were sacrificed on the same day i.e., day 11. The dose volume was 0.2 ml for all the treatments. Tamoxifen and taurine dose schedules are based on the preliminary investigation involving a range of doses and also from previously published reports [3], [4], [12], [14] and [15].
 

Jeez that was a healthy dose of Tamox! 50mg/kg :jaw:

Thanks for that! I wonder how megadosing Taurine works with other hepatoxic substances?

I know a lot of guys are up in the 4-8g/day to combat back pumps, perhaps this is an added bonus? I've never got pumps that bad, but I do take it quite liberally as it makes a good filler when you cap your own supps.

You must spread some Reputation around before giving it to rpen22 again.

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Our results indicate that taurine protects against TAM-induced hepatotoxicity and may be of therapeutic potential in alleviating the systemic side effects of chemotherapeutics. The present findings demonstrate that the antioxidative potential of taurine could be attributed to its modulatory effect on the xenobiotic bioactivation and detoxification processes. The study shows that the use of taurine supplementation might be helpful in abrogation of TAM toxicity. It is further suggested that taurine may prove to be useful as a component of combination therapy in cancer patients under TAM treatment regimen. In conclusion, the findings of the current study illustrate that exogenously administered taurine is capable of reversing the oxidative toxic effects of TAM. These data suggest that taurine, by preventing hepatic toxicity, may enhance the selectivity of antitumor drugs in the patients who require high doses of TAM. Additional studies are warranted to explore further the potential of taurine as a protective agent against toxicity of other anticancer drugs.
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