Yohimbine Homebrew

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  1. Yohimbine Homebrew


    Alright guys, we need to get this topic going. I didn't know where to put it, so feel free to move it. I want to give a homemade yohimburn product a shot. Eventually, once we get a formula that is proven effective, it would be a great product to add for sale on the site. I hope I don't need to tell you I don't give a damn if lipoderm is better. Yohimburn works and I think we could come up with something similar that works well enough for us to spend the time and money on. Here are yohimburns ingredients: 3500mg OF YOHIMBINE hcl, PURE ALOE VERA GEL, DISTILLED WATER, JAPANESE PEPPERMINT OIL and GLYCERIN. Does anyone have any ideas on what amounts would be good to start off with?

    BTW Curt, when you do get some Betas going of this I would be proud and obliged to be one of the testers.


  2. Curt, BDC could you just add in the Yohimbine HCL into the current premixed available on this site?

    And DMSO
    Read This Book!!: Anabolic Steroids and the Athlete by William N. Taylor M.D.
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  3. I would guess yes, it would work!

  4. Is the peppermint oil for smell? Does Yohimbine HCL stink?

  5. hmmm...T-Heat?

    Sounds like a winner...I'm already looking into acquiring the ingredients so this is right on. Be warned that this project will be about a month down the road before betas are released.

    Chemo
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  6. I would think they would be in these ratios or about.

    50% aloe gel
    20%water
    10%pepermint(which the active ingredient is menthol which d-limilone is a derivitve thats why par uses it)good pe
    10%glycerin could be replaced by PG no problem

    What do you think....Talk to ya

    You could no tuse the existing fromula. As far as I know Yom(as we will call it for short) is hydroliphic( soluable in water) and ours is lipotrophic solution(oil soluable) or whatever.

    Also the problem is slow release. But of course all of these can be combated.....

    This is what I suggest we start with.

    50%aloe gel
    20%water
    10%d-limonene
    10%propylene glycol

    Let me know what you think...The pepemint oil is expensive so that is what we need to replace with a inexpensive alternitive. d-limonene seems like the best choice........ Talk to ya...
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  7. Sounds like a good starting point...everyone got the ingredients?

    Aloe gel, 99% = Wal-mart ($2.99)
    Water, DI = Wal-mart ($0.99)
    d-limonene = Lemelange or whatever is left over from your 1-test brew
    prop glycol = Lemelange or whatever is left over from your 1-test brew

    I'll get back to you bros on a price for powders and divy it out to the beta brewers

    Chemo

  8. O/T


    Dammit, I love you guys...all of you are motivated, hard-working, dedicated individuals who are totally into helping people, and I would love to shake your hands (imaginarilly [sp?] of course).


    Either that...OR...

    ...I'm just a dumb lifeguard
    Read This Book!!: Anabolic Steroids and the Athlete by William N. Taylor M.D.

  9. To due popular demand, here is my formula

    For an 240 **ml** bottle of homebrewed yohimbine transdermal use the following:

    7.000 Grams of Yohimbine-HCL
    120ml Pure Aloe Vera Gel
    105ml Water
    15ml Pure Synthetic Peppermint Oil


    Aloe should not be a problem to get. The Peppermint oil I found at a herbal store over here, it cost me about $6.50 for the 15ml. Check online there are many retailers that carry it. For the Y-HCL a good source that retails it for pretty cheap is good ol' 1fast400.com. Total cost was about $35.00 for an 8oz bottle.

    One thing about Transdermal Y-HCL's is you want to do your best to sustain as much as possible in the adipose tissue. I believe Avant Lab's product does this by rapidly transporting the Y-HCL through the skin, and then slowing it down so it stays in the adipose for as long as possible. For formula listed here is simple but works. The Aloe will mosturize the skin, allowing it to open up for penetration by the l-menthol (peppermint oil) which permeates through lipid pathways. You add glycerol for better mostuirization, but I didnt feel it was really necessary.

    If anyone tries this same forumla out let us know how your results go.
    Last edited by curt2go; 10-08-2002 at 01:55 AM.

  10. One mistake, the total price came out to about $45.00 for 240ml. Thats $35.00 for the y-HCL and another $10.00 for the aloe + peppermint oil.

  11. Here is on of the studies that Par had in his explination on Lipoderm-Y.

    Transdermal delivery and accumulation of indomethacin in subcutaneous tissues in rats

    J Pharm Pharmacol 1998 Feb;50(2):153-8 (ISSN: 0022-3573)
    Mikulak SA; Vangsness CT; Nimni ME
    Department of Biochemistry & Molecular Biology, School of Medicine, University of Southern California, Los Angeles 90033, USA.
    Oral non-steroidal anti-inflammatory drugs (NSAIDs) are effective pharmacotherapy for a wide variety of painful, inflammatory disorders. Development of an efficient means of topical administration of NSAIDs could increase local soft-tissue and joint concentrations while reducing systemic distribution of the drug, thereby reducing side-effects. With this in mind we studied the effects of a novel topical penetration enhancer for lipophilic compounds, a trans-phase delivery system (TPDS), a solution of benzyl alcohol, isopropanol and acetone, on the distribution of indomethacin in various tissues locally and remote from the site of application. We compared the TPDS with a 50:50 (v/v) mixture of propylene glycol and ethanol, a commonly used penetration enhancer, and with oral administration. We found that the TPDS was significantly superior to the other approaches at achieving high local-tissue concentrations in the vicinity of the site of application. In addition, comparison of these two carrier systems seems to clarify the different aqueous and hydrophobic pathways of drug penetration which emerge from various experimental findings and theoretical considerations. Our results suggest that this non-aqueous solvent system, and benzyl alcohol in particular, because of its unique physicochemical and solvating characteristics, might be able to deliver therapeutic levels of indomethacin to tissues close to the site of application in a safer and more effective manner than presently accepted forms of delivery.


    Would these links help in formulating an alternative?

    http://www.novagali.com/Tech/Cationi...ulsionText.htm

    http://www.rci.rutgers.edu/~zatz/Del.../Niosomes.html

  12. Great posts Megadeth! And so the research begins...

    Pay attention to the second link --> VERY interesting info

    Chemo

  13. From what I read in these is that PG is a good thing to keep in for yom...



    http://www.cop.ufl.edu/safezone/prok...5110/skin.html good skin model

    http://www.cop.ufl.edu/safezone/prok...0/Ointment.htm gives descriptions

    http://www.cop.ufl.edu/safezone/prok...0/Nonionic.gif shows chems
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  14. Par has this in one of his articles...

    Lipophilic substances diffuse easily through stratum corneum lipids, but have much more trouble with the aqueous layers below (the vice versa is true for hydrophilic substances). If transport slows too much in any layer of tissue -- be it stratum corneum, epidermis, or dermis -- diffusion slows, causing a buildup in the outer layers.
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  15. The biggest thing that will stop yom from penetrating is dry skin. We need to use substances that hydrate the skin as well as penetrate..... Talk to ya.

    PG
    PPG
    G
    aloe
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  16. Well I am changing it a bit . I think the addition of DMSO will be good not in large amount but a small amount to help penetration. The DMSO will let anything in lipophic or hydophilic. Also at 2% concentration th absorption won't be too fast. Also doing some reading and I don't think speed is an issue. When the yom gets under your skin to the fat it will stay there and do its thing. So the speed of penetration is not as much of a factor as i first thought...But I could be wrong.. Talk to ya

    60% aloe to make it a gel
    10% propylene glycol(a must for hydrphilic substances)
    10% d-limonene( shown to be a good penetrant for hydroliphics)
    8% water (It will promote absorption of hydroliphics)
    2% DMSO(cause it helps anything to get in)

    Last edited by curt2go; 10-08-2002 at 05:06 PM.
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  17. Great stuff guys, This website is already becoming one of my favorites. This is really the only kind of stuff I visited BBing.com for anyway. I think I might try it with a similar solution to Diablo's except use less water and throw in the glycerol, since I have some sitting around. What should be more effective, glycerol or PG? I also might use D-limonene instead of the peppermint oil. The only problem with that is with 10% I get to smelling mighty citrusy. Diablo, how was the smell with the peppermint? Did you smell like it for long, or did it wear off relatively fast?

    BDC, have any idea on the price for yohimbine? Maybe you could get that up on the site before the actual brew gets put up. I figure I will be buying my 1-test here now, so being able to buy bulk yohimbine here too would be great.

  18. looks like max/day is 333mg/day is MAX.. But daily dose ranges fom 60-150 mg/day. i would say that application should be 2 times per day split into 50mg/application...

    This means that 3g will last 30days......... Talk to ya.
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  19. Originally posted by PLer
    BDC, have any idea on the price for yohimbine? Maybe you could get that up on the site before the actual brew gets put up. I figure I will be buying my 1-test here now, so being able to buy bulk yohimbine here too would be great.
    I have a request in with my supplier...will post yo powder prices as soon as I get them.

    Also:
    • 1,4-androdiol
    • 3,6,17-androstenetriol
    • 19-nor-diol
    • Whey protein powder


    Notice that EVERYTHING listed above is a -diol or -triol Of course, not the protein...

    Chemo

  20. Originally posted by Big Daddy Chemo

    [*]3,6,17-androstenetriol



    I'm a little excited about this one



    The Dumb One


    P.S. Why 1,4-androdiol and not dione?
    Read This Book!!: Anabolic Steroids and the Athlete by William N. Taylor M.D.

  21. Originally posted by Lifeguard
    P.S. Why 1,4-androdiol and not dione?
    Patent issues and the fact that -diols are generally more effective than their -dione counterparts. Although it is more expensive than the -dione it should prove to be more effective.

    Chemo

  22. Originally posted by Big Daddy Chemo


    Patent issues and the fact that -diols are generally more effective than their -dione counterparts. Although it is more expensive than the -dione it should prove to be more effective.

    Chemo

    Doesn't Sci-Fit make a Diol version called Andro-poise or something like that?
    Read This Book!!: Anabolic Steroids and the Athlete by William N. Taylor M.D.

  23. Originally posted by PLer
    Great stuff guys, This website is already becoming one of my favorites. This is really the only kind of stuff I visited BBing.com for anyway. I think I might try it with a similar solution to Diablo's except use less water and throw in the glycerol, since I have some sitting around. What should be more effective, glycerol or PG? I also might use D-limonene instead of the peppermint oil. The only problem with that is with 10% I get to smelling mighty citrusy. Diablo, how was the smell with the peppermint? Did you smell like it for long, or did it wear off relatively fast?

    BDC, have any idea on the price for yohimbine? Maybe you could get that up on the site before the actual brew gets put up. I figure I will be buying my 1-test here now, so being able to buy bulk yohimbine here too would be great.
    As for the smell, it has a strong peppermint scent. Usually it calms down a few minutes after application. You can use D-limonene as well it is quite effective and it wont have that strong peppermint scent.

    PG is far better PE when compared to glycerol. Glycerol is a good mosturizer which is a must for this homebrew. I think PG will penetrate too fast and will cause the y-hcl to end up in the bloodstream a little too quick. Curt, Chemo - thoughts?

  24. Originally posted by Big Daddy Chemo


    Patent issues and the fact that -diols are generally more effective than their -dione counterparts. Although it is more expensive than the -dione it should prove to be more effective.

    Chemo
    I believe Bill Lleweyn said himself that the dione is actually more effective then the diol version for this particular compound.

  25. Hmmm....link? What was the explanation he gave? Seems counter intuative.

    Chemo
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