Yohimbine Homebrew

Page 4 of 11 First ... 23456 ... Last

  1. SKAZZEL:

    curt2go, I am concerned about drying times with all of that aloe and water in there. I think 10 minutes is about the max anyone would want to have to wait around for it to dry.


  2. ME:

    Thats why I am going to try it out. Yom free...... I love beta testing...... Talk to ya.... Just goto get my hands on some cornmint tommorow... then its all good. As far as the rubbing in I think it will be fine. With the 10% water we are we are only talking 2ml/application @ 30mg/ml(7g in 240ml) which is only .2ml of water which is not very much and 1ml aloe. Not very much at all... Uh oh just thought of something.. The thread above says disolves in 10mg/ml of water with only 24ml of water to get even 3.5g to disolve in just the water is 145mg/ml... Just thinking out loud here. i may have a problem........CRAP!!!!!!!!!!! ! I am going ot have to think on this tonight.. Talk to ya...
    •   
       


  3. ME:

    How the hell does everyone elso disolve it??????? it does not disolve in alcohol!!!!! **** CRAP DAM..... This pisses me off.....CRAP... talk to ya

  4. NDN:

    Originally posted by curt2go Well after careful considerations I think this is what I will try... Just need the yom hcl now.... i will try to mix this tommorow and tell you how it goes.... Just a 120ml batch without yom...
    48%Aloe gel**must be 100%** (PE and skin hydrator)
    15%Isopropyl myristate(PE)
    15%cornmint oil(80%menthol)
    10%water(heated and yom put in)
    10%Propylene Glycol(PE and skin hydrator)
    2%DMSO(just because)
    It should be very cheap to make the costly ingredient will be the yom @ 5$/gram from 1fast What do you think????


    Its not bad but the formula looks like we would get more into the bloodstream instead of the adipose tissue, something we do not want.
    Try this formula out:
    50% Aloe gel
    20% Benzyl Alcohol
    15% Cornmint oil
    10% Water
    5% Glycerol
    I would think this forumla would do a great job of delerving the y-hcl to the adipose tissue. Thoughts?

  5. SKAZZEL:

    ndn, I like it. I am still wary of the additional water, as aloe is mostly water in the first place. I suppose it all depends on if we can get 6 grams of yhcl dissolved into heated aloe. Due to some of the studies I have seen regarding a combo of IPA and BA I might do something like:
    50% Aloe gel
    10% Benzyl Alcohol
    10% Isopropyl Alcohol
    15% Cornmint oil
    10% Water
    5% Glycerol
    or, if we can get the yhcl dissolved in the heated aloe:
    50% Aloe gel
    15% Benzyl Alcohol
    15% Isopropyl Alcohol
    15% Cornmint oil
    5% Glycerol
    I think this would give better results than yohimburn for sure, and might even be close to lipoderm. To be honest, with lipoderm only $43.99 at 1fast400, it will be hard to make a worthwhile homebrew. The yohimbine itself will be $30 (or $24 if bought in 10g quantities or more), so at best you are looking at $30-35 / bottle of questionable homebrew vs proven lipoderm for $44. Not quite the huge savings homebrew has over say 4aderm (especially with the new homebrew recipe, which with the DMSO probably surpasses avant lab's formula) - $40 for avantlabs, or ~$20 for homebrew.
    •   
       


  6. ME:

    What does the benzyl alcohol do?

  7. ME:

    Just did a quick test... 10ml 100%aloe vera and 2ml water. ABout the 50% 10% split in my recipe... Well i applied 4ml to 1 ARM and it rubbed in in about 2 min and 1 min more to completely dry.. There is no reson for ISO to help with drying of this stuff. I still have not figuerd out how we will get the yom into the solution yet????? Still working on that. I am going to order some yom tonight..... Talk to ya...

  8. ME:

    Well here is the info on benzyl alcohol.. jUst a presevative. PAR PUTS IT IN BECAUSE OF THE LONG SHELF LIFE.HEHEHE.. I don' t think its worth it to have in here. Just another chem that does nothing for us. Unless someone elso know what it is used for as well. It is an alcohol so it won't disolve the yom..... Talk to ya. As for th addition of the DMSO it only gets the yom through the SC. Since we are only putting it on fatty deposits the yom will have a hard time gettinginto bloodvessels(not too many in fat). I think it is a good addition... Talk to ya.

    Just trying to simplify everything for everyone... Hope it helps.. Talk to ya.

    Chemical Fact Sheet Chemical Abstract Number (CAS #) 100516 Synonyms Benzyl alcohol Benzenemethanol Analytical Method EPA Method 8250A Molecular Formula C7H8O Use MANUFACTURE OF OTHER BENZYL CMPD; SOLVENT FOR CELLULOSE ACETATE; IN PERFUMERY & IN FLAVORING; SOLVENT FOR GELATIN, CASEIN (WHEN HOT), & SHELLAC; IN MICROSCOPY AS EMBEDDING MATERIAL MEDICATION (VET): HAS BEEN USED FOR RELIEF OF PRURITUS AS A LACQUER SOLVENT & PLASTICIZER Photographic developer for color movie films; dyeing nylon filament, textiles & sheet plastics; heat-sealing polyethylene films; intermediate for benzyl esters and ethers; ball point pen inks; stencil inks PRESERVATIVE IN OPHTHALMIC PREPN Medication: It is used as a preservative in newborn medication such as bacteriostatic saline, heparin, phenobarbital injection, pancuronium, aquamephyton, and neonatal trace metal soln. Degreasing agent in rug cleaners. Used for the preservation of aqueous and oily parenteral drugs, in cough syrups, ointments, ophthalmic, burn, and dental solutions, insect ointments and repellents, and dermatological aerosol sprays. It is used as a solvent for dyestuffs. Benzyl alcohol is used in cosmetics, such as nail lacquers and hair dyes. Consumption Patterns 60% IS USED IN THE TEXTILE INDUSTRY AS A DYE ASSISTANT (MOSTLY FOR DYEING NYLON CARPETING); AND 40% IS USED IN OTHER APPLICATIONS (1972) Apparent Color WATER-WHITE LIQ Odor FAINT AROMATIC ODOR Boiling Point 204.7 DEG C Melting Point -15.19 DEG C Molecular Weight 108.13 Density 1.04535 @ 20 DEG C/4 DEG C Odor Threshold Concentration 5.5 ppm Sensitivity Data It is slightly irritating to the skin . Vapor: Irritating to eyes, nose and throat. Liquid: Irritating to skin & eyes. Environmental Impact Benzyl alcohol may enter the environment through fugitive emissions during its production, and during its formulation and use in commercial products. It may also enter the environment from the exhaust of motor vehicles. If released to soil, benzyl alcohol is expected to display high mobility and readily leach through soil. Volatilization from dry soil to the atmosphere may be an important fate process; however, it is not expected to be an important process in moist soils. Microbial degradation in soil may occur, based on limited data. If released to water, benzyl alcohol is expected to undergo microbial degradation under aerobic and anaerobic conditions. Neither volatilization to the atmosphere, hydrolysis, direct photolytic degradation, chemical oxidation, bioconcentration in fish and aquatic organisms, nor adsorption to sediment and suspended organic matter are expected to be significant processes in environmental waters. In the atmosphere, benzyl alcohol is expected to exist almost entirely in the vapor phase. The estimated half-life for the vapor phase reaction of benzyl alcohol with photochemically produced hydroxyl radicals is 2 days. Its water solubility suggests that benzyl alcohol may undergo deposition to the surface by rain washout and other wet deposition processes. Occupational exposure to benzyl alcohol may occur by dermal contact and inhalation during its production or formulation. Benzyl alcohol finds use in numerous consumer products which may result in exposure by dermal contact, inhalation, or ingestion during their use. Environmental Fate TERRESTRIAL FATE: If released to soil, benzyl alcohol is expected to display high mobility and readily leach through soil(1,2,3). Microbial degradation in soil may occur, based on limited data(4,5). Volatilization from dry soil to the atmosphere may be an important fate process(6,SRC); however, it is not expected to be a significant process in moist soils(7,SRC). AQUATIC FATE: If released to water, benzyl alcohol is expected to undergo microbial degradation under aerobic(1-7) and anaerobic(8,9,10) conditions. ATMOSPHERIC FATE: Based on a vapor pressure of 0.11 mm Hg at 25 deg C , benzyl alcohol is expected to exist almost entirely in the vapor phase in the ambient atmosphere . The estimated half life for the vapor phase reaction of benzyl alcohol with photochemically produced hydroxyl radicals in the atmosphere is 2 days(3,SRC). Based on its water solubility, 40 g/l, it may undergo dissolution into clouds and subsequently be removed from the atmosphere in precipitation. Drinking Water Impact GROUNDWATER: Benzyl alcohol was found in a groundwater sample taken at an unauthorized waste site, at a concn of 170 ug/L . EFFL: Benzyl alcohol has been identified in the waste water effluent from the photographic processing industry and in the effluent from Kraft paper mills in 6 out of 8 samples at a concentration up to 0.025 mg/l . Benzyl alcohol has been qualitatively determined in the secondary effluent from wastewater treatment plants in Illinois . The effluent from a Los Angeles county waste water treatment plant contained 500 ug/l of benzyl alcohol . Benzyl alcohol has been detected in the leachate from a Barcelona, Spain, sanitary landfill and from a municipal refuse disposal site in the Netherlands(6). Benzyl alcohol was qualitatively detected in the wastewater of a petrochemical company producing olefins and oxygenated hydrocarbons(7). Benzyl alcohol was found in the effluent of 1 out of 4 test waste incinerators(8).

  9. SKAZZEL:

    curt2go, Sounds good, but doesn't alcohol also help with penetration (should at least act as a solvent for any oil on the skin)?

  10. ME:

    That is what the reserch says.the alcohol is not needed here... The penetration effects are minimal... EVER USED ANDROSOL(MY POINT EXACTLY)....hehehehe
    YOHIMBINE FORMULA-C21H26N2O3
    MELTING POINT- 235 C.
    BOILING POINT- SUBLIMES
    SOLUABILITY
    WATER-SLIGHTLY SOLUBLE
    ALCOHOL-SLIGHTLY SOLUBLE
    ETHER-SLIGHTLY SOLUBLE
    BENZENE-SOLUBLE WHEN HOT
    ETHER- CHLORFORM-SLIGHTLY SOLUBLE
    RETURN TO INDEX
    YOHIMBINE HYDROCHLORIDE FORMULA-C21H26N2O3.HCL MELTING POINT- 235 C.
    SOLUABILITY WATER- SOLUBLE WHEN HOT
    ALCOHOL-SLIGHTLY SOLUBLE
    ETHER-INSOLUBLE ACETONE-INSOLBULE

    Yohimbine.HCl [Y1002] Description: alpha2-adrenoceptor blocker. Chemical Formula: C21H26N2O3.HCl
    Molecular Weight: M.W. 390.9
    Solubility: Soluble in Water (10 mg/ml).
    CAS Number: CAS [65-19-0]
    Active Product: N
    Appearance: White to Off-White Solid Purity: >99%
    Handling: Store in Tightly Sealed Vial.
    Storage: Room Temperature.
    Shipping: Express Courier

    Literature Reference: 1. Merck Index., 1996., 12:, 10236.. Bulk Quantity: Inquire

    I am going to drop the IPM just for cost savings... This is what I like so far:
    48%aloe vera
    25%water
    15%Cornmint oil(Menthol 80%)
    10%PG
    2%DMSO
    I realy think there is no need for any alcohol in this stuff. Water is very cheap........ Then without the ISO it is fine to use PG instead of glycerol.... Talk to ya.. What do you guys think.....

  11. ME:

    The yom will be added to the aloe water mix then heated I think to get the yom disolved. That will be the only work with the t-heat.... Talk to ya... PS. I have some yom on order now. I will be using this by the end of the week.... Talk to ya

  12. SKAZZEL:

    Yohimbine.HCl [Y1002] Description: alpha2-adrenoceptor blocker. Chemical Formula: C21H26N2O3.HCl
    Molecular Weight: M.W. 390.9
    Solubility: Soluble in Water (10 mg/ml).
    CAS Number: CAS [65-19-0]
    Active Product: N
    Appearance: White to Off-White Solid
    Purity: >99%
    Handling: Store in Tightly Sealed Vial.
    Storage: Room Temperature.
    Shipping: Express Courier
    Literature Reference: 1. Merck Index., 1996., 12:, 10236..

    ****. This is only ~2.4g in 8oz.

  13. ME:

    Thats what i was having a problem with. I will do some testing as soon as I get it.. I will just add 1g at a time until no more can go in. I will heat the aloe and water solution and add yom... We will see. I live spending money for reserch.... talk to ya..

  14. DADDYR:

    Benzyl Alcohol is, of course, most well known amongst us because of its use in oil-based injectable 'roids as a preservative, preventing microbial growth and reducing the risk of infections. Note that under the right condition, you can get pretty nasty amounts of bacteria growing in a matter of days. Especially if you remove the Isopropyl Alcohol, I would think you'd want a little BA. Someone already mentioned concerns about DMSO carrying unwanted contaminants through the skin. I would think you would want that homebrew to remain as free of infectious agents as possible while you're working your way through the bottle. Or maybe not. Worthy of discussion I think.

  15. SKAZZEL:

    It is also notable that the lipoderm formulation uses BA as it's #2 ingrediant (with IPA at #1), which means there is a signifigant amount in there - more than would be required to just act as a preservative.

  16. WELL THERE THEY ARE YOU GUYS OWE ME BIG... hehehe. Talk to ya.
  17. Thumbs up


    WOW! You never cease to amaze me Curt! Everyone be sure to give a big thanks to the man

    Chemo

  18. Wewp! We definately all owe you one curt!

  19. Ahhh both of you just shut up and post something good for once.... hehehe...
    Talk to ya..
  20. Thumbs up


    Curt

    I am absolutley astounded at the amount of work that you have put into this thread, I am impressed.














    (i'm still not gonna do my cycle until november, hehe )
    Read This Book!!: Anabolic Steroids and the Athlete by William N. Taylor M.D.

  21. Ok here is a little more...
    We may need to put some alcohol in but just to make a menthol solution... Here is what i came up with. I can get 500g of menthol crystals for 50cad 30usd... it takes 66mg disolved in 100ml of ISO to make a 75% menthol solution(same as cornmint oil)... This would take the place of the cornmint oil. menthol crytals are more redily avalibe and cheaper I think. And here is why....

    You take 500g mentholdisolve it in 750ml of ISO and you get 750ml's of 75% solution menthol.....
    If we use 15% in the recipe then we need 36ml/240ml bottle..
    Then we can get the menthol for 20.8 bottles for about $35.. That s for about $1.70/ bottle fo4r the menthol. Now thats not too bad... Here would be the price aprox for the recipe that I will use...


    48% aloe $1.00
    25% water(free)
    15% menthol(in alcohol) solution $1.70
    10% PG $0.20
    2% DMSO$0.50
    Y-hcl 3.5g for 1month supply...$17.50

    Well what do you guys think about $21.00 Is that going to cut it...
    This is a minimal ingredient recipe for least dollars..........

    PS. I did not do the calc on the solution. My sister in law did and she is in chem eng so i trust it.. But I did really figure it out. Yeh thats what we wil go with.. hehehe Talk to ya..

  22. curt2go,

    Looks good bro. Did you mean 66g instead of mg for the menthol? If it is 66mg, you would get much more than 20 bottles out of 500g, no? Are you going to mix some up soon and give it a shot?
  23. Ok, tell me what you guys think.


    There's an article in Duchaine's Dirty Dieting called The Art of Spot Reduction. It basically the states that there is such a thing as spot reduction(we all know this) and goes on to explin a more involved method than simple Yohimbine.

    The steps include:

    1. Increasing cAMP in the area in which the fat loss is desired. The methods they recommend are injectable clenbuterol or albuterol.

    2. Once cAMP is elevated in the fat cells, an enzyme called phosphodiesterase(PDE) wil appear. PDE destroys cAMP so we have stop take care of the PDE. Two PDE inhibitors are suggested (amrinone & milrinone), but they are next to impossible to get. The next best things for destryoing the PDE's are theophylline or caffeine.

    3.The next step is either destoying or blocking the Alpha 2 receptors. One unatainable drug called atipamezole detroys them and as we all know, Yohimbine blocks them.

    4.The more cAMP rises, the more adenosine is found in the fat cells. Adensine needs to be blocked also, but the caffeine or theophylline will do the trick.

    5. Start slow with each step. First as the beta agonist, then a few days later the PDE inhibitor and lastly the Alpha 2.

    I was thinking of using albuterol or a mixture of albuterol and forskolin to raise cAMP, theophylline & Yohimbine, in three different transdermal mixtures.

    Has anyone else read this article or have any suggestions on what trans mixture might be best for each compund??

  24. Originally posted by curt2go
    Ok here is a little more...
    We may need to put some alcohol in but just to make a menthol solution... Here is what i came up with. I can get 500g of menthol crystals for 50cad 30usd... it takes 66mg disolved in 100ml of ISO to make a 75% menthol solution(same as cornmint oil)... This would take the place of the cornmint oil. menthol crytals are more redily avalibe and cheaper I think. And here is why....

    You take 500g mentholdisolve it in 750ml of ISO and you get 750ml's of 75% solution menthol.....
    If we use 15% in the recipe then we need 36ml/240ml bottle..
    Then we can get the menthol for 20.8 bottles for about $35.. That s for about $1.70/ bottle fo4r the menthol. Now thats not too bad... Here would be the price aprox for the recipe that I will use...


    48% aloe $1.00
    25% water(free)
    15% menthol(in alcohol) solution $1.70
    10% PG $0.20
    2% DMSO$0.50
    Y-hcl 3.5g for 1month supply...$17.50

    Well what do you guys think about $21.00 Is that going to cut it...
    This is a minimal ingredient recipe for least dollars..........

    PS. I did not do the calc on the solution. My sister in law did and she is in chem eng so i trust it.. But I did really figure it out. Yeh thats what we wil go with.. hehehe Talk to ya..
    Curt, first of all thanks bro for reposting the thread! your a good bro!

    I like the idea of using dissolved menthol crystals in the solution. But I am still a bit weary on the DMSO. This is a new formula I came up with that should be close to yohimburn's formula:

    50% Aloe
    34% Water
    6% L-Menthol
    10% - Glycerol
    3.5 g y-hcl (4oz bottle) or 7 grams for 8oz bottle


    I think duplicating yohimburn's formula is the cheapest and most effective way of creating a yhcl homebrew. Yohimburn has been reported by many to deliver the results it claims - on the spot fat reduction. If we can duplicate it then I would think we would have a pretty good homebrew.
  •   

      
     

Similar Forum Threads

  1. Homebrew Yohimbine HCL Oral?
    By houseman in forum Supplements
    Replies: 13
    Last Post: 06-29-2004, 06:47 AM
  2. curt2go's homebrew...here's the results
    By gadzid in forum Pics
    Replies: 64
    Last Post: 01-24-2003, 07:47 AM
  3. Absorbtion rate of homebrews?
    By Jorta in forum Anabolics
    Replies: 6
    Last Post: 11-21-2002, 03:51 PM
  4. Ephedra Homebrew
    By ChaseRoy in forum General Chat
    Replies: 7
    Last Post: 11-02-2002, 10:00 PM
  5. homebrew dosage
    By Stez in forum Supplements
    Replies: 5
    Last Post: 10-31-2002, 01:01 AM
Log in
Log in