After being a supplement whore for years, I've come to find out that, personally, 90% of them are useless. 5% of them may have anecdotal evidence. And, the other 5% are actually beneficial in one way or another. It also seems that the down sides outweigh the good sides, but people tend to ignore that. Yeah, I could gain an extra inch or two on my biceps, but I may die 10 years early for it, too.
I take some risks. Even creatine mono hasn't been studied long term. It's virtually impossible to take all the risk out of it, but I try to limit my exposure.