The Anabolic Minds Supplement Roundtable

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  1. Give the thread a chance. Id like to think this can be used as a platform for layman's terms answers to people's questions that arent so much advanced but for which if they were to search the forums they wouldnt really find a clear concise answer.

    Regarding creatine stability , creatine monohydrate is highly stable for extended periods of time in water
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  2. Quote Originally Posted by De__eB View Post
    Give the thread a chance. Id like to think this can be used as a platform for layman's terms answers to people's questions that arent so much advanced but for which if they were to search the forums they wouldnt really find a clear concise answer.

    Regarding creatine stability , creatine monohydrate is highly stable for extended periods of time in water
    Alright Deebs I'm going to use this to my benefit as a supplement enthusiast. Talk to me about berberine man. You and or @Synapsin. I've seen a few studies comparing it to metformin. Being in a large chunk of gda's would you mind giving a basic rundown so people can understand how awesome this ingredient is?
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  3. Quote Originally Posted by Spaniard View Post
    Alright Deebs I'm going to use this to my benefit as a supplement enthusiast. Talk to me about berberine man. You and or @Synapsin. I've seen a few studies comparing it to metformin. Being in a large chunk of gda's would you mind giving a basic rundown so people can understand how awesome this ingredient is?
    Berberine is underrated imo and one that many people should include in their stacks from time to time. Lowers LDL and blood triglycerides; and for those that don't know, when blood triglycerides are high, LDL particles become smaller and more dense, thus making them more likely to be oxidized and form plaque on arteries (atherosclerosis/ heart disease).
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  4. Quote Originally Posted by ELROCK View Post
    What is the reasoning behind separating the doses of creatine and agmatine?
    Physiologically, there's no reason unless you have a cognitive or mitochondrial disorder.

  5. Quote Originally Posted by mr.cooper69 View Post
    Physiologically, there's no reason unless you have a cognitive or mitochondrial disorder.
    Or if trying to benefit from the cognitive properties of creatine
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  6. (Tribulus Aquaticus (Stem and Leouriaf) Extract, Chebulic Myrobalan (Bean) Extract)
    "To your wife you should kiss try today"-Touey

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  7. Quote Originally Posted by Touey View Post
    (Tribulus Aquaticus (Stem and Leouriaf) Extract, Chebulic Myrobalan (Bean) Extract)
    ? This a question, comment?

  8. Quote Originally Posted by jbryand101b View Post
    ? This a question, comment?
    ANYONE can table an ingredient (not company or product) at which point we will all discuss the ingredients in a conducive fashion. We will discuss it like King Arthur and his Knights discussed who's ass they were going to go kick!


    (Tribulus Aquaticus (Stem and Leouriaf) Extract, Chebulic Myrobalan (Bean) Extract)
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard

  9. Quote Originally Posted by Spaniard View Post

    Alright Deebs I'm going to use this to my benefit as a supplement enthusiast. Talk to me about berberine man. You and or @Synapsin. I've seen a few studies comparing it to metformin. Being in a large chunk of gda's would you mind giving a basic rundown so people can understand how awesome this ingredient is?
    Quote Originally Posted by Jiigzz View Post

    Berberine is underrated imo and one that many people should include in their stacks from time to time. Lowers LDL and blood triglycerides; and for those that don't know, when blood triglycerides are high, LDL particles become smaller and more dense, thus making them more likely to be oxidized and form plaque on arteries (atherosclerosis/ heart disease).
    If one is considering berberine, he/she definitely needs to be aware of the host of CYP interactions.
    EvoMuse

  10. Quote Originally Posted by Touey View Post

    ANYONE can table an ingredient (not company or product) at which point we will all discuss the ingredients in a conducive fashion. We will discuss it like King Arthur and his Knights discussed who's ass they were going to go kick!

    (Tribulus Aquaticus (Stem and Leouriaf) Extract, Chebulic Myrobalan (Bean) Extract)
    Oh, you want to talk about it.

    Okay, what is it? Cause Idk. Is it Inteteresting enough for me to want to search and read about it?

    If so, why?

  11. Quote Originally Posted by jbryand101b View Post

    Oh, you want to talk about it.

    Okay, what is it? Cause Idk. Is it Inteteresting enough for me to want to search and read about it?

    If so, why?
    Fruit and water chestnut extracts...outside of that I could never find much outside of anecdotal feedback on being very good or not good(GI effects or none).

    Edit: berberine is solid. Using it in AP right now on high carb meals.
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  12. Quote Originally Posted by Spaniard View Post
    Or if trying to benefit from the cognitive properties of creatine
    No, unless you have cognitive decline or mt disorders that require supraphysiological doses of creatine for phosphate donation and/or allosteric modulation of the NMDA receptor. I hate to say it but the examine.com authors are data miners...they don't know how to interpret it. Creatine has a saturating effect, so according to them, we can never take agmatine period if we want to boost cognitive function, even if our last creatine dose was 12 hours ago. Agmatine will block the NMDA receptor in a manner independent of creatine's allosterism, so there is no real antagonism, just independent effects

  13. Berberine is legit. I think a major reason it's not more heavily touted for actual therapeutic effects on diabetes is because it lowers the Cmax of many co-ingested drugs while simultaneously reducing metabolism

  14. Quote Originally Posted by mr.cooper69 View Post
    Berberine is legit. I think a major reason it's not more heavily touted for actual therapeutic effects on diabetes is because it lowers the Cmax of many co-ingested drugs while simultaneously reducing metabolism
    Some months back I kinda recall you had mentioned it could hinder the benefits of hypertrophy, that the carb blocking would be not ideal also for a bulk? Can you elaborate on this for the crowd Dr.Cooper?
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  15. Quote Originally Posted by Celorza View Post

    Some months back I kinda recall you had mentioned it could hinder the benefits of hypertrophy, that the carb blocking would be not ideal also for a bulk? Can you elaborate on this for the crowd Dr.Cooper?
    Induces AMPK, no?
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  16. Quote Originally Posted by Celorza View Post
    Some months back I kinda recall you had mentioned it could hinder the benefits of hypertrophy, that the carb blocking would be not ideal also for a bulk? Can you elaborate on this for the crowd Dr.Cooper?
    It's too complex an issue to address in a post (maybe a coop's corner?) but if you dose berberine properly, both amount and timing, it will be conducive to growth and performance. This is a dual function of its effects in the gut + AMPK activation

  17. Quote Originally Posted by rob112 View Post

    Induces AMPK, no?
    That is in a rat study and it apparently suppresses muscle growth, at least momentarily...but then refreshing myself some I came across something saying rats with increased AMPK got hungry faster and ate more; this growing in size. The second thing doesn't account for carb blocking of berberine which would cut some calories(I believe mildly). It's been awhile since I read about this stuff.

    Edit: what that guys says! ^^
    Training Log
    http://anabolicminds.com/forum/workout-logs/271254-what-aw-hell.html
    "Jackie Treehorn treats objects like woman man."

  18. Quote Originally Posted by mr.cooper69 View Post
    It's too complex an issue to address in a post (maybe a coop's corner?) but if you dose berberine properly, both amount and timing, it will be conducive to growth and performance. This is a dual function of its effects in the gut + AMPK activation
    I kinda am glad you addressed that though, because I remember before you were not really in favor of certain doses of it and lately your taste shifted and it does reflect on the fact that, like you said it is a Dose and Timing dependent matter!

    So now, who here would like to contribute trying to find out the Timing and Dosage needed for it to be more, or less, effective towards the benefits of hypertrophy and a bulk? @Synapsin perhaps...or does @De__eB wanna go at it?
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  19. Quote Originally Posted by mr.cooper69 View Post
    Berberine is legit. I think a major reason it's not more heavily touted for actual therapeutic effects on diabetes is because it lowers the Cmax of many co-ingested drugs while simultaneously reducing metabolism
    I remember you referring to berberine as "dirty" compound, and its use would best be served for cheat meal.
    EvoMuse

  20. Quote Originally Posted by domore View Post

    I remember you referring to berberine as "dirty" compound, and its use would best be served for cheat meal.
    Same here, now he is a fan! Good though, but share the knowledge of what changed Cybear!
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  21. ...

    Quote Originally Posted by Right Hook;
    Pretty great results. These people all had metabolic syndrome fwiw.

    Effect of Berberine Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.

    pubmed: berberine / by P?rez-Rubio KG, Gonz?lez-Ortiz M, Mart?nez-Abundis E, Robles-Cervantes JA, Espinel-Berm?dez MC / 23 hours ago
    Effect of Berberine Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.

    Metab Syndr Relat Disord. 2013 Jun 28;

    Authors: P?rez-Rubio KG, Gonz?lez-Ortiz M, Mart?nez-Abundis E, Robles-Cervantes JA, Espinel-Berm?dez MC

    Abstract
    Abstract Background: The aim of this study was to evaluate the effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Methods: A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients with a diagnosis of metabolic syndrome. Glucose and insulin levels after a dextrose load were measured. Triglycerides and high-density lipoprotein cholesterol concentrations at baseline were also measured. Twelve patients received berberine hydrochloride (500 mg) three times daily before meals for 3 months. The remaining 12 patients received placebo. Area under the curve (AUC) of glucose and insulin, total insulin secretion, first-phase of insulin secretion, and insulin sensitivity were assessed. Results: After berberine administration, patients had a remission of 36% (P=0.037) in the presence of metabolic syndrome and a significant decrease in waist circumference in females (106?4 vs. 103?3 cm, P<0.05), systolic blood pressure (SBP) (123?7 vs. 115?9 mmHg, P<0.01), triglycerides (2.4?0.7 vs. 1.4?0.5 mmol/L, P<0.01), area under the curve (AUC) of glucose (1182.1?253.6 vs. 1069.5?172.4 mmol/l, P<0.05), AUC of insulin (92,056?72,148 vs. 67,407?46,441 pmol/L, P<0.01), and insulinogenic index (0.78?0.69 vs. 0.62?0.46, P<0.05), as well as an increase in the Matsuda index (2.1?1.0 vs. 3.1?1.6, P<0.01). Conclusions: Administration of berberine leads to remission of metabolic syndrome and decreases in waist circumference, SBP, triglycerides, and total insulin secretion, with an increase in insulin sensitivity.
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  22. Quote Originally Posted by Celorza View Post
    Same here, now he is a fan! Good though, but share the knowledge of what changed Cybear!
    Data is always emerging about new compounds, at rates faster than ever before. Nothing is in stone

  23. Quote Originally Posted by mr.cooper69 View Post
    Berberine is legit. I think a major reason it's not more heavily touted for actual therapeutic effects on diabetes is because it lowers the Cmax of many co-ingested drugs while simultaneously reducing metabolism
    Berberine is definitely underrated. People seem to hav an issue with its mTOR properties seem on the effect of atrogin 1

    But that has been discussed

  24. Quote Originally Posted by EBF Inc View Post

    Berberine is definitely underrated. People seem to hav an issue with its mTOR properties seem on the effect of atrogin 1

    But that has been discussed
    I like it!
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  25. Quote Originally Posted by mr.cooper69 View Post

    Data is always emerging about new compounds, at rates faster than ever before. Nothing is in stone
    ^^^ very true statement.
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