D Aspartic Acid & Negative side effects
- 03-10-2011, 09:15 PM
My guess is that the natural formation from the L-isomer isn't all too significant. Too pick up the slack, you probably have a high receptor density, and thus the capacity for more more activation through external DAA supplementing.
- 03-10-2011, 09:17 PM
03-10-2011, 09:17 PM
03-10-2011, 10:36 PM
I started getting really bad anxiety on DAA and I've never had it before.. I've since stopped but am still getting it, but noticeably less often.. I don't suggest DAA is solely to blame for this, however it is interesting that it's declined since I stopped taking it.
03-11-2011, 12:51 AM
So to sum up what I've read thus far. DAA has been shown to increase test in in vivo studies, but nobody can produce a single study showing this excitotoxicity that some are stating as "fact." Please, if you have a study, post it, otherwise that is worse than bro science...it's bad science.
03-11-2011, 12:58 AM
03-11-2011, 09:03 AM
The amino acid, D-aspartate, exists in the mammalian brain and is an agonist at the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors.
03-11-2011, 09:18 AM
03-11-2011, 09:19 AM
03-11-2011, 09:25 AM
I've run DAA on 3 seperate occasions. I've used bulk from NP & TCF-1. Minimum run was 2 weeks, max was a month. Each time I've noticed the following:
-Better workouts & recovery
-More of an "alpha male" mentality when working out
-sleep wasn't as sound or as good as it normally is
-bloating. I seem to hold water when taking it
-mood is off just a bit
Does it work? I think it does raise "T" levels for me. I do get some acne on my back but I didn't experience any crazy rise in libido though.
03-11-2011, 10:01 AM
Your third citation shows that DAA is an agonist of NMDA, BUT never once shows it to be excitotoxic. Just because something is an agonist, does not make it excitotoxic! DAA is a precursor to the biosynthesis of NMDA, but even that does not mean it will lead to excitoxicity. If any compound in use today has been shown to have excitotoxic properties, it is nitric oxide, but even that is not always the case and the mass amounts of arginine you would need to ingest to actually make this possible across the blood brain barrier make it a moot point.
You're talking about endogenous neurotransmitters in relation to an event like excitotoxicty which requires a unique set of circumstances to occur. The simple act of increasing neurotransmission will not cause excitotoxicity.
I'm not trying to be a jerk, just trying to keep you honest because I keep seeing this said with no evidence. So I will repeat my challenge. Can anybody show a single in vivo study where DAA causes excitotoxicity?
03-11-2011, 10:06 AM
03-11-2011, 10:19 AM
All the science leads to what has been stated, being a neuroscientist I would assume you would provide a word of caution given the facts presented. As I have yet to see you provide in vivo studies proving to the contrary I can only assume you have some vested interest, even after the aforementioned statement. In our PM you even agreed with me about DAA converting to N-Methyl-D-Aspartate, but then gave a "Yes, but" that something that is a known excitotoxin is no long an excitotoxin in this instance?!
As a neuroscientiest I would expect you to err on the side of caution. Seems incongruous to your self proclaimed profession.
The Historic PES Legend
03-11-2011, 10:29 AM
This is real easy and let me talk slow so even my "retard" brain can keep up. Can anybody show one single study where DAA causes excitotoxicity?
I'm asking for my own personal knowledge and don't care if the study was performed in humans, rats or trees. Just one!
03-11-2011, 10:34 AM
Ive bben taking 4.5 g a day for 9 days with no sides except some diarhea 2 days. Not noticing strength increases yet. I have anxiety and havent felt different.
03-11-2011, 10:34 AM
The above studies I posted show that DAA is an NMDA agonist itself, is converted to NMDA, and that excesive NMDA stimulation is excitotoxic.. Until some studies are done on humans I will draw my own conclusions based on the available scientific literature..
03-11-2011, 10:39 AM
You have not posted any studies to the contrary and all scientific literature points in the opposite direction so until you produce some safety studies you really have no point.
03-11-2011, 10:40 AM
If I was so far off base you wouldn't get so defensive and begin providing studies to the contrary.
The Historic PES Legend
03-11-2011, 10:56 AM
03-11-2011, 11:06 AM
I believe that this thread is about exposing potential effects so that users can make their own decision on the benefits/risk.. Honestly, the test boost that has been shown is hardly enough to produce effects beyond what an AI would. AI tests showed test was raised far beyond what DAA does and there are not the same exitotoxic risks involved.
03-11-2011, 11:13 AM
1) I never once said DAA is safe or should be used by anybody
2) I never once said DAA does increase test levels and in fact I have yet to see convincing evdidence that it does (those boar testicle studies do little to convince me)
3) I simply asked if DAA has been shown to cause excitotoxicity because I looked and could not find a single study and thought perhaps you all could point me in the direction of one
4) When answered with studies that did not actually answer my question, I said why they did not and asked again
So everybody have a wonderful day. I need to get back to my imaginary job with my imaginary degree.
03-11-2011, 11:20 AM
I started this thread after the whole NMDA issue was brought up several times in random DAA threads, but were quickly ignored. I myself ignored them till I was set to run a long cycle of DAA and a certain member took the time to explain to possible side effects.
I'm very glad I was made aware of what I could do to myself and that's why I started this thread, so other could be aware. I could care less if some kills their body with supplements, steroids or drugs. It's their body go for it. I just don't want to see anyone use something while they're unaware of the sides....
03-11-2011, 11:27 AM
In the end, it's only going to help increase test levels a bit. I think Bubsnt hit the nail on the head. It's an excitotoxin, which may raise test levels a little bit. I have a feeling that in a few years this substance will be like creatine monohydrate to a lesser degree. Some people love it, some people only get side effects, and some people are 'non-responders'.
03-11-2011, 11:36 AM
03-11-2011, 11:37 AM
I'm looking at a different study, a different dosage, and a different sampling time.
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