D Aspartic Acid & Negative side effects
- 12-08-2011, 05:55 PM
This topic kind of got out of hand - almost 30 posts between my last one and now? lol. At any rate, I thought this particular thread was interesting and is beginning to touch on DAA and excitotoxicity concerns: Anyone with low T any success with Natural TBoosting supplements or herbs
To respond to Easy, my thing is that I understand 's MoA, and I know it's a metabolite. But you have to consider that when you ingest DAA, it's not all being taken up in the brain, it's not all being metabolized to NMDA, and it requires a certain level of NMDA to damage neurons to the point that they die. Low levels merely excite the cells (though NMDA is a potent receptor agonist, granted). So, I think you're right (easy) in saying that the final word is still unknown. Absolutely.
I guess I was just letting my opinion get the best of me, so my B.
Also, found something interesting: http://www.ncbi.nlm.nih.gov/pubmed/20861489 was used in this study to modulate NMDA signaling causing a knockdown of cellular Ca2+ influx. This was done I believe on tissue cultures, not people (for beyond obvious reasons). So if you're concerned about the excitotoxicity of the DAA metabolite, you could take an extra step and dose it with .
- 12-08-2011, 09:22 PM
- 12-08-2011, 09:30 PM
Coco is gone? Now who am I gonna play with? BWA!...... but seriously, I was wondering on the whole NDMA thing, I see "muscle warfare" has it for sale.... even in vitamin shoppe not just randomly online.... I read taking NDMA was a bad idea on the net various places, but that DAA was not nearly as "bad"....still unclear on what the deal is. I am assuming its like taking a precursor vs taking the actual substance straight up.
12-08-2011, 11:03 PM
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12-09-2011, 11:13 AM
OK thanks guys. That is what I gathered, that there was no safe dosage for NMDA and that it could be dangerous at certain dosages. You would figure if you took enough DAA that could be harmful as well, but maybe not......
12-09-2011, 11:19 AM
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12-09-2011, 12:01 PM
first couple of logs:
sorry about bunk links, still a noob in the eyes of AM
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possible role of NMDA receptors in muscle nerve transmission?
Muscle Nerve. 2011 Dec;44(6):987-9. doi: 10.1002/mus.22250.
NMDA receptors at the endplate of rat skeletal muscles: Precise postsynaptic localization.
Malomouzh AI, Nurullin LF, Arkhipova SS, Nikolsky EE.
Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia. firstname.lastname@example.org.
In this study we demonstrate expression of the N-methyl-D-aspartate receptor NR1 subunit in the rat neuromuscular junction of skeletal muscles of different functional types (extensor digitorum longus, soleus, and diaphragm muscles) using fluorescence immunocytochemistry. Electron microscopic immunocytochemistry has shown that the NR1 subunit is localized solely on the sarcolemma in the depths of the postsynaptic folds. These findings suggest participation of the glutamatergic signaling system in functioning of the adult mammalian neuromuscular junction.Muscle Nerve, 2011.
Copyright © 2011 Wiley Periodicals, Inc.
PMID: 22102472 [PubMed - in process]
Anabolicminds.com Featured Author
12-09-2011, 06:20 PM
I tried taking DAA twice, both times I couldn't sleep a wink a couple of days after I started. Worst insomnia ever. Sucks because I bought 3 tubs, so had to give them away
12-09-2011, 06:23 PM
This is all so very confusing and the consensus is, there is no consensus.What I've been able to gather so far regarding NMDA, is that it does more harm than good.
12-09-2011, 07:22 PM
Any of the supposed "harm" that NMDA causes it when it's applied directly directly to brain matter. You plan on removing your skull and applying liberally? LOL nope
Everyone had concerns when DAA came out, and then everyone realized they were wayyyy overblown.
Same is here.
iForce's new INTIMIDATE is pure NMDA and is going to make quite a few people happy with some impressive results.
12-09-2011, 08:47 PM
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12-09-2011, 10:28 PM
the bad part is that despite the fact the stuff is gonna work, since we already know big brother will work just as good and probably better than little brother.....but again, no way we will know long term sides....and the short term sides will be similar to DAA of course. So I doubt we learn much new info other than I am certain the loggers results should be superior to DAA.
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