What Is The Best Nutrient Partitioning Supplement?

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  1. I heard that Omega is coming out with a nutrient partitioner.


  2. Quote Originally Posted by criticalbench View Post
    Lots of supplements use agmatine and most dose it at 1000mg.. if your going to place yours over every other, what other stuff does yours have?

    Mike
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  3. While not marketed as a NP, or proven to be one in numerous studies, I suspect Anabeta is a good one. I get lean with very little effort (diet wise) and often feel hypoglycemic if I take it before a meal. Pumps can be decent as well if timed correctly before a workout.

  4. Correct me if I'm wrong but if it had nutrient partitioning effects rather than GDA effects it wouldn't make you go hypo... Would it? Don't get me wrong i love anabeta, its likely my favorite supplement but idk if it necessarily has NP effects. GDA I could see, NP I'm not so sure

  5. Quote Originally Posted by Irish Cannon
    LG Sciences SLIN was pretty intense. I loved using it for nutrient repartitioning.

    Prior to fasted training, I never found anything better than AP.

    Keep in mind I haven't been taking supps for over two years. Probably lots of great stuff out there.
    Always wanted to try the LG SLIN. Gone now I think.
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  6. Quote Originally Posted by Wocheezy View Post
    Correct me if I'm wrong but if it had nutrient partitioning effects rather than GDA effects it wouldn't make you go hypo... Would it? Don't get me wrong i love anabeta, its likely my favorite supplement but idk if it necessarily has NP effects. GDA I could see, NP I'm not so sure
    I think you have this backwards. GDA -- clears glucose. NP -- selectively targets muscle cells over fat cells. We're hoping there is a GDA that is also an NP. So far I have not seen evidence of this.

  7. Quote Originally Posted by Wocheezy View Post
    Correct me if I'm wrong but if it had nutrient partitioning effects rather than GDA effects it wouldn't make you go hypo... Would it? Don't get me wrong i love anabeta, its likely my favorite supplement but idk if it necessarily has NP effects. GDA I could see, NP I'm not so sure
    People have mentioned partitioning effects with Anabeta, but honestly I have never really bought that. Number one what does partitioning feel like? Number two has Anabeta ever been shown to do that in studies? Seemed to me that was something people made up for the other positive effects of Anabeta.

    Don't get me twisted, not bashing the supplement at all it's a huge hit....but I never really knew what people meant when they talked about it partitioning. Probably a catch all term for feeling Anabeta working.
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  8. Quote Originally Posted by jerrysiii View Post
    I think you have this backwards. GDA -- clears glucose. NP -- selectively targets muscle cells over fat cells. We're hoping there is a GDA that is also an NP. So far I have not seen evidence of this.
    I know the difference, which is why I'm saying a GDA could make you go hypo, and I have had this happen before with recompadrol. I was wondering if a NP even has the potential to make you go hypo. Also, wouldn't it be more beneficial if it was a NP but NOT a GDA? Maybe I am confused but wouldn't disposing of glucose be detrimental if a NP was targeting muscle cells rather than fat cells?

  9. Quote Originally Posted by Wocheezy View Post
    I know the difference, which is why I'm saying a GDA could make you go hypo, and I have had this happen before with recompadrol. I was wondering if a NP even has the potential to make you go hypo. Also, wouldn't it be more beneficial if it was a NP but NOT a GDA? Maybe I am confused but wouldn't disposing of glucose be detrimental if a NP was targeting muscle cells rather than fat cells?
    The idea is to selectively shuttle the glucose from your blood into muscle cells. When you eat a carbohydrate it is either going to:

    1) be used directly for energy
    2) stored as glycogen in muscle or liver
    3) stored as fat

    We want one of the first two options.

  10. Quote Originally Posted by Geoforce View Post
    People have mentioned partitioning effects with Anabeta, but honestly I have never really bought that. Number one what does partitioning feel like? Number two has Anabeta ever been shown to do that in studies? Seemed to me that was something people made up for the other positive effects of Anabeta.

    Don't get me twisted, not bashing the supplement at all it's a huge hit....but I never really knew what people meant when they talked about it partitioning. Probably a catch all term for feeling Anabeta working.
    Nutrient repartitioning effects can be dependent on any number of mechanisms. Testosterone has nutrient repartitioning effects in athletes ... you eat the same food, more of it goes to synthesizing lean mass (muscle/glycogen), and fat gets "starved"/catabolized. This isnt' because test sensitizes you to insulin (it might do the opposite, I kind of forgot what I read on this), but because the energy demands of skeletal muscle in those exercising are so increased that nutrients are driven into these cells over fat cells.

    It's possible Anabeta does its work by a similar mechanism. I definitely believe it has NP effects considering how eating more leads to an increase in weight but also an increase in definition (presumably a decrease in bf).
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  11. While the study doesn't analyze effect in 3t3 adipocytes, the conclusion section is quite interesting. Remember, Slintensity introduces to the market the first 80% 4-Hydroxy Isoleucine standardized Extract.
    Eur J Nutr. 2012 Oct;51(7):893-8. Epub 2012 May 19.
    4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway.

    Jaiswal N, Maurya CK, Venkateswarlu K, Sukanya P, Srivastava AK, Narender T, Tamrakar AK.
    Source

    Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, India.

    Abstract

    PURPOSE:

    To determine the effect of 4-Hydroxyisoleucine (4-HIL), an unusual amino acid isolated from the seeds of Trigonella foenum-graecum, on glucose uptake and the translocation of glucose transporter 4 (GLUT4) to plasma membrane in skeletal muscle cells and to investigate the underlying mechanisms of action.
    METHODS:

    Rat skeletal muscle cells (L6-GLUT4myc) were treated with 4-HIL, and the effect on glucose uptake was determined by measuring the incorporation of radio-labeled 2-deoxy-[(3)H]-D-glucose (2-DG) into the cell. Translocation of GLUT4myc to plasma membrane was measured by an antibody-coupled colorimetric assay.
    RESULTS:

    The prolonged exposure (16 h) of L6-GLUT4myc myotubes to 4-HIL caused a substantial increase in the 2-DG uptake and GLUT4 translocation to the cell surface, without changing the total amount of GLUT4 and GLUT1. Cycloheximide treatment reversed the effect of 4-HIL on GLUT4 translocation to the basal level suggesting the requirement of new protein synthesis. The 4-HIL-induced increase in GLUT4 translocation was completely abolished by wortmannin, and 4-HIL significantly increased the basal phosphorylation of AKT (Ser-473), but did not change the mRNA expression of AKT, IRS-1, GLUT4, and GSK3β.
    CONCLUSION:

    Results suggest that 4-HIL stimulates glucose uptake in L6-GLUT4myc myotubes by enhancing translocation of GLUT4 to the cell surface in a PI-3-kinase/AKT-dependent mechanism.

    PMID:22610671 [PubMed - in process]
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  12. I have some slintensity coming in the mail. I completely forgot to order Na-R-ALA, though. Big fail!
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  13. Also, see this. I have brought a new angle to the whole GDA/NP approach by incorporating the Momordin standardized Bitter Melon Extract. Momordin has been shown to be a promoter of PPAR-delta activity...

    Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3444-9. Epub 2006 Feb 21.
    PPARdelta regulates glucose metabolism and insulin sensitivity.

    Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM.
    Source

    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

    Abstract

    The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in response to fatty acids and, as such, are potential therapeutic targets for these diseases. We show that PPARdelta (NR1C2) knockout mice are metabolically less active and glucose-intolerant, whereas receptor activation in db/db mice improves insulin sensitivity. Euglycemic-hyperinsulinemic-clamp experiments further demonstrate that a PPARdelta-specific agonist suppresses hepatic glucose output, increases glucose disposal, and inhibits free fatty acid release from adipocytes. Unexpectedly, gene array and functional analyses suggest that PPARdelta ameliorates hyperglycemia by increasing glucose flux through the pentose phosphate pathway and enhancing fatty acid synthesis. Coupling increased hepatic carbohydrate catabolism with its ability to promote beta-oxidation in muscle allows PPARdelta to regulate metabolic homeostasis and enhance insulin action by complementary effects in distinct tissues. The combined hepatic and peripheral actions of PPARdelta suggest new therapeutic approaches to treat type II diabetes.

    PMID:16492734 [PubMed - indexed for MEDLINE]
    PMCID:PMC1413918
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  14. dsade, the science in the two studies you posted is a little beyond my understanding. Do either suggest selectivity of muscle over fat cells?

  15. Quote Originally Posted by jerrysiii View Post
    dsade, the science in the two studies you posted is a little beyond my understanding. Do either suggest selectivity of muscle over fat cells?
    The PPARdelta study supports a partitioning effect (rather a metabolic boost in muscle tissue, and increased carbohydrate clearance via liver activity). The first study, as I mentioned, does not do a comparison for selectivity.
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  16. Quote Originally Posted by dsade View Post
    The PPARdelta study supports a partitioning effect (rather a metabolic boost in muscle tissue, and increased carbohydrate clearance via liver activity). The first study, as I mentioned, does not do a comparison for selectivity.
    Dos slintensity prevent the absorption of carbs? When i take slin sane, it works great for preventing fat gain, but I can't carb load with it, because I feel it wont let me suck enough up.

    Mike
    Hi-Tech Pharmaceuticals Representative

  17. Quote Originally Posted by criticalbench View Post
    Dos slintensity prevent the absorption of carbs? When i take slin sane, it works great for preventing fat gain, but I can't carb load with it, because I feel it wont let me suck enough up.

    Mike
    dont say that.. I just bought SSv2 yesterday! Anyways, 2 caps of R-ala seems to give me the feeling that my bodys absorbing all the carbs I throw at it.. Up to a point, of course.

  18. Cool study Dsade - thanks.

    I ask this respectfully as I'd just like to get your opinion on this.

    General question here: It is my understanding these darn mice studies are SOMEHWHAT (not totally) useless

    Seems like mice studies are both utilized AND refuted when convenient.

    Thanks D

    Quote Originally Posted by dsade View Post
    Also, see this. I have brought a new angle to the whole GDA/NP approach by incorporating the Momordin standardized Bitter Melon Extract. Momordin has been shown to be a promoter of PPAR-delta activity...

    Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3444-9. Epub 2006 Feb 21.
    PPARdelta regulates glucose metabolism and insulin sensitivity.

    Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM.
    Source

    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

    Abstract

    The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in response to fatty acids and, as such, are potential therapeutic targets for these diseases. We show that PPARdelta (NR1C2) knockout mice are metabolically less active and glucose-intolerant, whereas receptor activation in db/db mice improves insulin sensitivity. Euglycemic-hyperinsulinemic-clamp experiments further demonstrate that a PPARdelta-specific agonist suppresses hepatic glucose output, increases glucose disposal, and inhibits free fatty acid release from adipocytes. Unexpectedly, gene array and functional analyses suggest that PPARdelta ameliorates hyperglycemia by increasing glucose flux through the pentose phosphate pathway and enhancing fatty acid synthesis. Coupling increased hepatic carbohydrate catabolism with its ability to promote beta-oxidation in muscle allows PPARdelta to regulate metabolic homeostasis and enhance insulin action by complementary effects in distinct tissues. The combined hepatic and peripheral actions of PPARdelta suggest new therapeutic approaches to treat type II diabetes.

    PMID:16492734 [PubMed - indexed for MEDLINE]
    PMCID:PMC1413918
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  19. Ingredients in Slintensity has my interest peaked for sure with the more I read on the 4-OH. And I've always liked Gymnema Sylvestre when used in other products. For sure have a win here Matt as always.

  20. Quote Originally Posted by Whacked View Post
    Cool study Dsade - thanks.

    I ask this respectfully as I'd just like to get your opinion on this.

    General question here: It is my understanding these darn mice studies are SOMEHWHAT (not totally) useless

    Seems like mice studies are both utilized AND refuted when convenient.

    Thanks D
    http://ec.europa.eu/research/health/...5082010_en.pdf

    From ursolic acid to anabeta and tons of others it's mice studies that bring new products to the market. By no means is it a perfect setup, but a necessary one for a myriad of reasons I'm sure you're aware of. Based on feedback, mice or human, Slintensity seems to be doing a ton of great things. Honestly we haven't seen any negative feedback throughout all our boards yet and we haven't had a single log. These are all customers who weren't swayed with free product, but people who bought it with their own money.
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  21. You mean that bodybuilders would NOT appreciate being locked in a terrarium, having their diet tightly controlled, blood taken at all hours of the day and night and then ultimately euthanized and dissected?

    I dunno, I'd be OK with saving some mice and experimenting on some of the less constructive board members here...but I'm not a MOD any more. lol



    Quote Originally Posted by Geoforce View Post
    http://ec.europa.eu/research/health/...5082010_en.pdf

    From ursolic acid to anabeta and tons of others it's mice studies that bring new products to the market. By no means is it a perfect setup, but a necessary one for a myriad of reasons I'm sure you're aware of. Based on feedback, mice or human, Slintensity seems to be doing a ton of great things. Honestly we haven't seen any negative feedback throughout all our boards yet and we haven't had a single log. These are all customers who weren't swayed with free product, but people who bought it with their own money.

  22. Sup Geo

    Yeah yeah, I was already well-aware. My point is this:

    People often cite mice studies to support their cause and then just as easily dismiss it when they want to challenge a product.

    I am not referring to Dsade here. Just IN GENERAL. We can't have it both ways.

    And truth be told, the vast majority of mice studies do NOT cross over successfully into the human realm results-wise.

    Quote Originally Posted by Geoforce View Post
    http://ec.europa.eu/research/health/...5082010_en.pdf

    From ursolic acid to anabeta and tons of others it's mice studies that bring new products to the market. By no means is it a perfect setup, but a necessary one for a myriad of reasons I'm sure you're aware of. Based on feedback, mice or human, Slintensity seems to be doing a ton of great things. Honestly we haven't seen any negative feedback throughout all our boards yet and we haven't had a single log. These are all customers who weren't swayed with free product, but people who bought it with their own money.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  23. The studies on Glut4 specific actions generally use transgenic mice, expressing human GLUT4.
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  24. I was looking forward to the live logs from beta testers from the board.

    Blake didn't even send me any!
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  25. Quote Originally Posted by Whacked View Post
    Sup Geo

    Yeah yeah, I was already well-aware. My point is this:

    People often cite mice studies to support their cause and then just as easily dismiss it when they want to challenge a product.

    I am not referring to Dsade here. Just IN GENERAL. We can't have it both ways.

    And truth be told, the vast majority of mice studies do NOT cross over successfully into the human realm results-wise.
    Not always, but sometimes certainly. If you look at any of the recent "hit" supplements of the last 4 years almost every single one of them with a novel ingredient came from what was seen in a mice study. Anabeta's ingredient didn't have anything going for it other than what it was shown to do in mice. Same with ursolic acid and the list could go on indefinitely. Tis the nature of the beast.

    I've been the exact same as you and know exactly what you mean my man. The fact is most supplements have few human studies behind them. And the ones that do are all after it has been shown to do stuff in rodent models, then been experimented with and shown real world results, then human studies. Which it could work the other way, but we all know the reasons it can't.
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