Applied Nutriceuticals IGF-2 
Overview:
Product Overview:
The compounds contained in IGF-2™ stimulate a variety of complex reactions and messenger systems in the body, most notably through direct gene activation and the second messenger system. Safed Musli, Mucuna Pruriens, and Dodder Seed all have been shown to increase testosterone production in the body via a number of different mechanisms.
FAQ
Q: When is the best time to take IGF-2?
A: Take first dose on an empty stomach first thing in the morning, 45 minutes before a meal. On non-workout days, take second dose in same fashion. On workout days, take second dose 45 minutes before workout, on an empty stomach. Take third dose on an empty stomach 45 minutes before bed time for maximal effectiveness.
Q: How long will it take me to notice the positive anabolic benefits from IGF-2?
A: You will begin to feel the testosterone and growth hormone increases from IGF-2 about 7-10 days after beginning the product, at which point you will notice measurable increases in strength and size. By the end of the third week, you’ll be feeling the full effects of this amazing product with ever-increasing gains in strength, size and density.
Q: What makes IGF-2 different from other anabolics on the market?
A: Not to be cynical, but this one actually works. We are proud that this product delivers exactly what we claim it to. The specifically titrated ratios of the compounds in IGF-2 trigger enormous increases in growth hormone and testosterone production, while serving a critical anti-catabolic function as well. Users of IGF-2 generally report lean body mass gains of 5-7 lbs. over an 8 week cycle, with even greater gains being reported when stacked with NeoVar, our advanced creatine product.
Q: How does IGF-2 boost testosterone levels, and how does testosterone grow more muscle?
A: The safed musli componet of IGF-2 contains large amounts of spirosta-steroidal saponins (desoxydiosgenin, tigogenin and neotigogenin) which are intermediates to various hormonal pathways in the body. When ingested, desoxydiosgenin from the safed musli is enzymatically converted to 11-oxa-5 alpha-androstane-3,17-dione, a portion of which is converted to testosterone through the testes. The testosterone produced binds to the androgen receptor, which signals the muscles via mRNA to increase protein synthesis, increased nitrogen retention and muscle cell hypertrophy; leading to greater strength, mass, and recovery.
Q: How does the L-Dopa in IGF-2 help with testosterone production and growth hormone secretion?
A: The variety of mucuna pruriens used in IGF-2™ is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule. Two important mechanisms of action of L-Dopa is increased growth hormone (GH) release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can hinder testosterone production. By inhibiting prolactin, IGF-2 increases endogenous testosterone levels dramatically. L-Dopa is a precursor to Dopamine, a potent GH and testosterone agonist, meaning that dopamine inhibits prolactin release and somatostatin secretion in the hypothalamus, which allows for a greater stimulatory effect of growth hormone-releasing hormone (GHRH) and secretion of testosterone by the testes. GHRH signals the pituitary to release GH, which is produced by the pituitary gland. GH is an important anabolic hormone that stimulates skeletal muscle cells to grow and, in some cases, divide. Acting directly, GH also mobilizes fats from fat depots and decreases the rate of glucose intake and metabolism.
Q: What anabolic and energy-enhancing actions does rhodiola rosea have?
A: Rhodiola rosea has been shown to increase ATP (Adenosine Triphosphate) production in the mitochondria of the cell. ATP is an energy molecule that allows for muscle contraction to occur. In a university study, mice were administered rhodiola and made to swim to exhaustion twice a day for six days. At the end of the testing period, muscle biopsies were performed, with the rhodiola-treated mice having 17% greater ATP levels, 45% greater creatine phosphate stores, and 53% greater muscle glycogen levels, along with lowered intramuscular concentrations of lactic acid and ammonia. What this means to you is stronger muscle contraction, allowing for improved energy and stamina.
In human studies, the rosavin and salidroside found in rhodiola rosea have also been shown to have significant effects on stress reduction. This is accomplished by reducing cortisol release, while optimizing levels of key brain chemicals involved in mood, such as serotonin and dopamine, which function together to maintain a healthy response to stress. Blocking cortisol is important, as cortisol tends to break down muscle tissue, increase body fat stores, slows the metabolism and lowers immune function. Rhodiola has been shown to have adaptogenic qualities, meaning that it allows humans to work harder during stress, while at the same time maintaining higher energy reserves.
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