creatine mono and ASGT
- 05-18-2010, 12:05 PM
- 05-18-2010, 02:36 PM
- 05-18-2010, 02:46 PM
05-18-2010, 02:47 PM
nteresting, would like to see this duplicated.
Clinical Journal of Sport Medicine
Issue: Volume 19(5), September 2009, pg. 399-404
Three Weeks of Creatine Monohydrate Supplementation Affects Dihydrotestosterone to Testosterone Ratio in College-Aged Rugby Players
Objective: This study investigated resting concentrations of selected androgens after 3 weeks of creatine supplementation in male rugby players. It was hypothesized that the ratio of dihydrotestosterone (DHT, a biologically more active androgen) to testosterone (T) would change with creatine supplementation.
Design: Double-blind placebo-controlled crossover study with a 6-week washout period.
Setting: Rugby Institute in South Africa.
Participants: College-aged rugby players (n = 20) volunteered for the study, which took place during the competitive season.
Interventions: Subjects loaded with creatine (25 g/day creatine with 25 g/day glucose) or placebo (50 g/day glucose) for 7 days followed by 14 days of maintenance (5 g/day creatine with 25 g/day glucose or 30 g/day glucose placebo).
Main Outcome Measures: Serum T and DHT were measured and ratio calculated at baseline and after 7 days and 21 days of creatine supplementation (or placebo). Body composition measurements were taken at each time point.
Results: After 7 days of creatine loading, or a further 14 days of creatine maintenance dose, serum T levels did not change. However, levels of DHT increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01).
Conclusions: Creatine supplementation may, in part, act through an increased rate of conversion of T to DHT. Further investigation is warranted as a result of the high frequency of individuals using creatine supplementation and the long-term safety of alterations in circulating androgen composition.
Statement of Clinical Relevance: Although creatine is a widely used ergogenic aid, the mechanisms of action are incompletely understood, particularly in relation to dihydrotestosterone, and therefore the long-term clinical safety cannot be guaranteed.
05-18-2010, 02:51 PM
now im interested in replicating this with myself. i was wondering how much creatine you would have to add if you were to dose one scoop of ASGT. a lg rep would be appreciated
05-18-2010, 10:07 PM
05-18-2010, 10:11 PM
05-20-2010, 04:04 PM
05-23-2010, 02:00 PM
05-23-2010, 03:08 PM
ASGT has your creatine needs covered, no need to do excessive dosing with creatine as 5g/day has been the long time standard for maximal saturation.
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05-23-2010, 11:02 PM
I wasn't sure about this either. I have been taking 1 scoop of asgt and mixing it with 1 scoop of PP's creapure 1 hour preworkout. It has been working great so far. Off topic a bit, I have andraulic pump as well, can I stack this with ASGT? Sorry if hijacked.
05-29-2010, 05:41 PM
no problem i saw in some threads that asgt and pump is a good stack.. a lot of ppl seem to be doing it, if that justify's anything lol
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