MK-677

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    MK-677


    Not much talk about this over here but maybe someone is thinking of trying it and if so what's stopping you?

    I'm going to order some and run it for about 3-6 months. I'm debating doing blood work before or during to see how high it boosts things. I'm wondering will it boost GH above normal for me or just up to about where I was at 19-22 years old so we will see how things play out soon enough.

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    There is some good info on MK-0677 on Dat's forum. Personally I won't be running it after reading the information on one of his posts. Why you ask? Because of desensitization. I'm not going to copy and paste the information, Dat hates that crap and i'm one of few who actually respect his wishes. I do however recommend joining his forum and reading the thread "Growth Hormone Secretagogues". Also, It has a 24 half life... So your bodies first pulse might be pretty big, then later on the second pulse who knows and the third pulse who knows.
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    I'll have to check that out.....there is a guy running it over at the **** forum who is noticing a great leaning effect. Just don't think/know if it's worth the $99 a month.
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    is there anyway to conteract this desensitization?
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    I always forget about that guys forum, ill try to join today.
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    I think its worth it if it works. I mean imagine gaining muscle even beyond what would normally be your max and losing fat at the same time while sleeping better at night. I plan to use it on cycle, pct, bridge then cycle again or it all could just be in my dreams but we will see.
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    I'm interested in it, bit I'm looking for more feedback on it before taking the plunge.
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    Damn this killed it

    The stimulatory effect of MK-677 on mean GH concentrations in the 8 h after drug administration declined between the first and fourth day of drug administration, although the fourth day value was still significantly greater than baseline. This decline may indicate desensitization to the GH stimulatory effects of the drug and foreshadow an eventual loss of stimulatory effect. Alternately, and probably more likely, it may result from negative feedback effects of IGF-I on GH secretion. There is evidence that IGF-I acts at pituitary and/or hypothalamic sites to suppress GH secretion (36, 37, 38, 39). The negative feedback effects of IGF-I would be expected to increase as circulating IGF-I concentrations increase in the days to weeks after starting MK-677 treatment. This would eventually result in a new set point at which IGF-I and GH concentrations are higher than at baseline, but GH concentrations are lower than immediately after initiation of treatment. Such changes have been reported in beagle dogs treated with oral MK-677 for 2 weeks (40).
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    Inspection of the GH profiles suggested that MK-677 increased serum GH concentrations by enhancing the preexisting pulsatile pattern of GH release. This was supported by the results of cluster analysis, which revealed a significant increase in GH peak height without change in peak number. Interpeak nadir GH concentrations were also significantly increased by MK-677 treatment. We have previously administered a compound related to MK-677 (L-692,429) to healthy older subjects by continuous 12- and 24-h intravenous infusions and assessed pulsatility by deconvolution analysis (17). We have also administered daily oral MK-677 to healthy older subjects for up to 4 weeks and assessed GH pulsatility by the cluster and ultra algorithms and deconvolution (35). There is agreement among all methods and studies that these compounds increase circulating GH concentrations by increasing the size, but not the number, of existing pulses, and that despite an increase in interpulse GH concentrations, GH secretion remains pulsatile. This enhancement of GH pulsatility occurs whether these compounds are administered continuously as intravenous infusions or as daily administrations of the long-acting compound MK-677. This suggests that these compounds amplify the normal signals responsible for episodic GH release. This could occur via relief of an inhibitory effect, such as that of somatostatin, enhancement of a stimulatory effect, such as that of GHRH, or a combination of both.

    full study

    http://jcem.endojournals.org/content/82/10/3455.full
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    Background: In animals, insulin-like growth factor-1 (IGF-1) increases clearance of β-amyloid, a pathologic hallmark of Alzheimer disease (AD), from the CNS. Serum IGF-1 level decreases with age, and shows a further decrease in AD. We examined whether the growth hormone secretagogue MK-677 (ibutamoren mesylate), a potent inducer of IGF-1 secretion, slows the rate of progression of symptoms in patients with AD.

    Methods: A double-blind, multicenter study was conducted in which 563 patients with mild to moderate AD were randomized to receive MK-677 25 mg or placebo daily for 12 months. Efficacy measures were mean change from baseline at month 12 on the Clinician's Interview Based Impression of Change with caregiver input (CIBIC-plus), the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog), Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL), and the Clinical Dementia Rating-sum of boxes (CDR-sob).

    Results: A total of 416 patients completed treatment and assessments at 12 months. Administration of MK-677 25 mg resulted in a 60.1% increase in serum IGF-1 levels at 6 weeks and a 72.9% increase at 12 months. In mixed-effects models that included treatment, time (month), randomization strata (baseline MMSE score ≤20 vs >20), and interaction of treatment-by-time, there were no significant differences between the treatment groups on the CIBIC-plus or the mean change from baseline scores on the ADAS-Cog, ADCS-ADL, or CDR-sob scores over 12 months.

    To me this indicates that the desensitization does not compound over time. That is a fairly large sample of patients and they actually had higher IGF-1 levels at 12 months than they did at 6 weeks.
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    Dat has is own forum? Mind telling me what it is? I loved his stuff a few years back when he did his initial write up and a couple other guys helped out a lot.
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    Quote Originally Posted by MentalTwitch View Post
    Dat has is own forum? Mind telling me what it is? I loved his stuff a few years back when he did his initial write up and a couple other guys helped out a lot.
    type datbtrue and let google do the walking.
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    I guess this stuff was a bust?
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    Quote Originally Posted by WhatsaRoid? View Post
    Damn this killed it

    The stimulatory effect of MK-677 on mean GH concentrations in the 8 h after drug administration declined between the first and fourth day of drug administration, although the fourth day value was still significantly greater than baseline. This decline may indicate desensitization to the GH stimulatory effects of the drug and foreshadow an eventual loss of stimulatory effect. Alternately, and probably more likely, it may result from negative feedback effects of IGF-I on GH secretion. There is evidence that IGF-I acts at pituitary and/or hypothalamic sites to suppress GH secretion (36, 37, 38, 39). The negative feedback effects of IGF-I would be expected to increase as circulating IGF-I concentrations increase in the days to weeks after starting MK-677 treatment. This would eventually result in a new set point at which IGF-I and GH concentrations are higher than at baseline, but GH concentrations are lower than immediately after initiation of treatment. Such changes have been reported in beagle dogs treated with oral MK-677 for 2 weeks (40).
    Sorry to resurrect this super old thread but....

    If you were to pulse mk-677 by taking 2-3 times a week after your hardest workouts, would this still be somewhat beneficial while avoiding negative feedback effects? I know it won't be as beneficial as a continuous cycle, but would it help at all? would it hurt?
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    Absolutely! MK-677 gives over a dozen low wave hgh pulses in a 24 hour period from one sublingual oral dosing. Everyday use will gradually elevate serum Igf1. HGH goes extremely high at first until the negative feedback loop kicks in, then it gradually goes lower as igf1 increases. By using it eod you should get a very high serum hgh secretion but your Igf1 will not elevate nearly as high as with everyday use.
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    In my opinion, MK-677 is the most convenient, cost effective, and powerful way to get your serum igf1 through the roof, along with damn near constant HGH secretion by way of a dozen HGH pulses. All you need is one oral sublingual 25mg dose of MK-677 per day to equate to approximately 5ius of HGH. The cost is about $1.50 a day.
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    Am very interested in running MK-677 after a pro hormone pre-competition cycle. Would like to try it throughout the summer to see its leaning effects. Would MK-677 be tough on someone with moderate adrenal fatigue? If anything wouldn't more growth hormone production produce healing effects in suboptimal organs? Anyone ever try Blue Sky Pep MK?
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    Will MK-677 bring any advantage when one's already optimizing his HGH release by fasting everyday from 16 to 18 hours?
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    Im not fasting for that length of time no way Jose. My cortisol levels would be outrageous.
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    Quote Originally Posted by TR2 View Post
    Sorry to resurrect this super old thread but....

    If you were to pulse mk-677 by taking 2-3 times a week after your hardest workouts, would this still be somewhat beneficial while avoiding negative feedback effects? I know it won't be as beneficial as a continuous cycle, but would it help at all? would it hurt?
    Quote Originally Posted by hardtoget View Post
    Am very interested in running MK-677 after a pro hormone pre-competition cycle. Would like to try it throughout the summer to see its leaning effects. Would MK-677 be tough on someone with moderate adrenal fatigue? If anything wouldn't more growth hormone production produce healing effects in suboptimal organs? Anyone ever try Blue Sky Pep MK?
    Quote Originally Posted by MaXopA View Post
    Will MK-677 bring any advantage when one's already optimizing his HGH release by fasting everyday from 16 to 18 hours?
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    I am running MK-677 from JJ. It is an excellent product.

    I am older, and my GH as measured via IGF-1 is low, even for my age.

    I basically am on GH replacement for life. I run 3 iu's of GH e2d. People will say that that amount is a waste, but for me that is absolutely not true. After 1 year I have gotten many good results.

    In regards to the MK-677, I take a month off of my GH replacement and run the 677 twice a day for 1 month. Then I go back on GH. I run 400 mgs of test/week 9-10 months out of the year.

    After 3 weeks I am getting sick pumps. I eat like a pig (I do insane intensity cardio and my labs are all good).

    After 1 month on the 677 I then go back to my GH replacement program.

    That way, I get around the feedback issue. I have no relationship with JJ, except buying 677 from him. I met him on another forum which is a scammer forum. The mods there are paid off to protect scammers, one of which burned me.

    I say that to make clear that I am in no way a shill. I run stuff and then give honest feedback.

    The 677 is a very good product. Every time there is a b1g1 sale I stock up.

    I know that it probably looks bad that I made a first post promoting a source....I would call bull**** if the roles were reversed.

    Nonetheless, I really like 677. The way I use it removes the problem of de-sensitization.
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    Actual GH therapy needs to be pulsed in a low dose about 1IU every 3-4 hours.

    MK677 only proves that if you dose a GHRP high enough it will be effecitve orally.

    You could just do 100mcg of GHRP-2 with 100mcg of Mod GRF (1-29) and save yourself the hassle.
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    Anyone know is superior is any good
  

  
 

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