Synthetic Supplements DopaDex
- 03-26-2014, 11:54 PM
- 03-27-2014, 12:14 AM
Already got the answer via PM. Apparently depends on what you're trying to accomplish with l-dopa and if you really want to take 5g ecgc. Doesn't fit what I'm going for, but happy to get a straight forward answer. Thanks though, bro
Edit: Realized you were looking for the same answer -- I was told no, it's not necessary to take ecgc, and yes, b6/p5p will battle to be taken by the same pathways as the dopa, so space them out if you're taking both.
03-27-2014, 08:52 AM
03-27-2014, 10:06 AM
Well PES amino iv is the only product I take with p5p in it and that's taken in the afternoon and dopa product is taken at bed time often at 11-midnight or later. So I'm assuming 6-8 hours is ok......
Does p5p affect prolactin then if it competes with dopa? Does it raise or lower prolactin
03-27-2014, 12:42 PM
Again, I was basically given the run down for dummies, so I could be off here, but that's how I understood what was told to me.
In my particular case, lowering/keeping prolactin in check is a goal, but I was also interested in getting a deeper, uninterrupted sleep because I tend to toss and turn throughout the night.
I take some b6 in the morning/early afternoon and take the dopadex later in the day/pre-bed in order to get the best of both worlds. I've seen this method suggested in other forums, and people reported having success with it.
I do think a lot of people overstate the benefits of the L-dopa, personally. I see people giving feedback about a supercharged attitude and confidence as if they've ingested molly at a rave. But whatever, I guess if they *think* it's working, that could be beneficial in itself.
03-27-2014, 12:45 PM
04-01-2014, 06:05 AM
04-01-2014, 06:06 AM
04-01-2014, 08:58 AM
04-01-2014, 01:08 PM
04-01-2014, 02:10 PM
04-01-2014, 02:11 PM
04-01-2014, 02:21 PM
04-01-2014, 02:51 PM
04-06-2014, 01:36 PM
Just wanted to share this study, which basically says B6 will inhibit the GH benefits from L-Dopa, but will enhance the prolactin lowering effects. Space them if you're looking for sleep/GH. Combine them if you're trying to reduce prolactin.
Edit: can't post links yet, but it's the "pubmed/20170" extension on the ncbi/pubmed website.
Here's the excerpt: 500 mg of levodopa was administered orally to 8 normal subjects and induced an increase of growth hormone (GH) and a decrease of prolactin (PRL) secretion. The levodopa-induced GH release was inhibited by an intravenous infusion of pyridoxine; on the contrary, the PRL response to levodopa was enhanced by pyridoxine infusion. This dissociation of GH and PRL responses to levodopa during pyridoxine infusion appears to be mediated by peripheral acceleration of the conversion of levodopa to dopamine. Since dopamine does not penetrate the blood-brain barrier, the enhanced PRL decrease observed during pyridoxine infusion might be explained only on the basis of a mechanism of action exerted by dopamine on extra blood-brain barrier sites.
04-06-2014, 01:48 PM
Also keep this in mind for your B6 supplementation -- many people suggest taking P5P over B6 due to bio availability, but pubmed 501547 says the following:
"To investigate if vitamin B6 inhibits prolactin release and to compare this effect to that of bromocriptine, a known suppressor of prolactin release, a study was conducted in male rats. Animals were pretreated with pyridoxine hydrochloride, pyridoxal hydrochloride, saline, or bromocriptine 30 min prior to receiving varying doses of chlorpromazine hydrochloride. Blood samples were obtained 90 min later and analyzed for serum prolactin by a double-antibody radioimmunoassay. Another study involved pyridoxal hydrochloride and saline pretreatments 30 min prior to doses of chlorpromazine hydrochloride. Blood samples collected 60 min later were also analyzed for serum prolactin. Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01). Pyridoxal hydrochloride, another natural form of vitamin B6, failed to suppress prolactin under the conditions of both studies. This investigation may lend support to the concept that pyridoxine hydrochloride partially inhibits prolactin by a mechanism not involving dopamine."
Essentially, the standard B6 (pyridoxine) will aid in reducing prolactin. P5P (pyridoxal) has no effect on prolactin. Hope this clears up any confusion, I know it did for me.
04-06-2014, 01:59 PM
04-06-2014, 02:40 PM
"On the other hand, in nine subjects who were younger than 50 years, maximum penile circumference increase showed a significant increment with L-dopa."
I would like to stress that we DO NOT want anyone conducting before and after logs with photos lol.
10-04-2014, 05:47 AM
10-12-2014, 01:06 PM
10-16-2014, 02:18 PM
Hey natty, coop, and other reps.
With the addition of chlorotest to the lineup, I'm thinking of 'making my own ' powerfull which I use regularly from usp. It's just chloro and dopa. They do not disclose how much of each, or what % extract. Can you give your best estimation of how much of dopadex+chlorotest I should use nightly? I use two caps of powerfull (750mg each). If I had to guess, I would say there's about 500mg chloro per cap and 250 dopa.
Would stacking the analyzed products at night yield similar/better results for prolactin and GH?
10-16-2014, 06:13 PM
10-16-2014, 06:18 PM
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