Synthetic Supplements DopaDex

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  1. Quote Originally Posted by Druboutin View Post
    Is it necessary to take ecgc with the dopadex to get its full benefits? I'm reading conflicting info regarding that (as well as the b6/p5p negating it's effects)
    Paging mr cooper

  2. Druboutin
    Druboutin's Avatar

    Already got the answer via PM. Apparently depends on what you're trying to accomplish with l-dopa and if you really want to take 5g ecgc. Doesn't fit what I'm going for, but happy to get a straight forward answer. Thanks though, bro

    Edit: Realized you were looking for the same answer -- I was told no, it's not necessary to take ecgc, and yes, b6/p5p will battle to be taken by the same pathways as the dopa, so space them out if you're taking both.
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  3. Quote Originally Posted by Druboutin View Post
    Already got the answer via PM. Apparently depends on what you're trying to accomplish with l-dopa and if you really want to take 5g ecgc. Doesn't fit what I'm going for, but happy to get a straight forward answer. Thanks though, bro

    Edit: Realized you were looking for the same answer -- I was told no, it's not necessary to take ecgc, and yes, b6/p5p will battle to be taken by the same pathways as the dopa, so space them out if you're taking both.
    Good info since a few products are combining p5p and l-dopa...I wouldn't have thought about the combination being negative.

  4. Well PES amino iv is the only product I take with p5p in it and that's taken in the afternoon and dopa product is taken at bed time often at 11-midnight or later. So I'm assuming 6-8 hours is ok......

    Does p5p affect prolactin then if it competes with dopa? Does it raise or lower prolactin
  5. Druboutin
    Druboutin's Avatar

    Quote Originally Posted by tyrub42 View Post
    Good info since a few products are combining p5p and l-dopa...I wouldn't have thought about the combination being negative.
    From what I understand, when they're combined the reaction happens outside the bbb, so the effects resulting in reduced prolactin are still achieved, but the mental benefits of the l-dopa are diminished. So if prolactin is your only focus, I believe a product like inhibit-P which combines them (and vitex) achieves that goal.

    Again, I was basically given the run down for dummies, so I could be off here, but that's how I understood what was told to me.

    In my particular case, lowering/keeping prolactin in check is a goal, but I was also interested in getting a deeper, uninterrupted sleep because I tend to toss and turn throughout the night.

    I take some b6 in the morning/early afternoon and take the dopadex later in the day/pre-bed in order to get the best of both worlds. I've seen this method suggested in other forums, and people reported having success with it.

    I do think a lot of people overstate the benefits of the L-dopa, personally. I see people giving feedback about a supercharged attitude and confidence as if they've ingested molly at a rave. But whatever, I guess if they *think* it's working, that could be beneficial in itself.
  6. Druboutin
    Druboutin's Avatar

    Quote Originally Posted by chedapalooza View Post
    Well PES amino iv is the only product I take with p5p in it and that's taken in the afternoon and dopa product is taken at bed time often at 11-midnight or later. So I'm assuming 6-8 hours is ok......

    Does p5p affect prolactin then if it competes with dopa? Does it raise or lower prolactin
    I would also assume that's fine. As I said above, I've come across others who are more knowledgeable than myself who suggested spacing them out as you did allows you achieve prolactin control from both angles without them competing with each other.

  7. Quote Originally Posted by chedapalooza View Post
    Well PES amino iv is the only product I take with p5p in it and that's taken in the afternoon and dopa product is taken at bed time often at 11-midnight or later. So I'm assuming 6-8 hours is ok......

    Does p5p affect prolactin then if it competes with dopa? Does it raise or lower prolactin
    It lowers it

  8. Quote Originally Posted by Druboutin View Post
    From what I understand, when they're combined the reaction happens outside the bbb, so the effects resulting in reduced prolactin are still achieved, but the mental benefits of the l-dopa are diminished. So if prolactin is your only focus, I believe a product like inhibit-P which combines them (and vitex) achieves that goal.

    Again, I was basically given the run down for dummies, so I could be off here, but that's how I understood what was told to me.

    In my particular case, lowering/keeping prolactin in check is a goal, but I was also interested in getting a deeper, uninterrupted sleep because I tend to toss and turn throughout the night.

    I take some b6 in the morning/early afternoon and take the dopadex later in the day/pre-bed in order to get the best of both worlds. I've seen this method suggested in other forums, and people reported having success with it.

    I do think a lot of people overstate the benefits of the L-dopa, personally. I see people giving feedback about a supercharged attitude and confidence as if they've ingested molly at a rave. But whatever, I guess if they *think* it's working, that could be beneficial in itself.
    Well I'll tell you one thing that isn't hype. Take dopadex for a few weeks then comment on orgasm quality...dead serious. Sex will never be the same

  9. Quote Originally Posted by mr.cooper69 View Post
    Well I'll tell you one thing that isn't hype. Take dopadex for a few weeks then comment on orgasm quality...dead serious. Sex will never be the same
    I never got this effect...and now I feel like I am missing out big time! Is this something almost everyone gets from L-dopa supps???

  10. Quote Originally Posted by mr.cooper69 View Post

    It lowers it
    Taking test powder with my amino IV= good/bad idea?? Test powder having200mg mucuna (seed) extract and amino IV w the p5p... Should I be trying to spread these out? Or no issue? Thanks coop
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  11. Quote Originally Posted by tyrub42 View Post
    I never got this effect...and now I feel like I am missing out big time! Is this something almost everyone gets from L-dopa supps???
    Not everyone but most users. It's been documented in human studies. Not to mention increased penile girth at rest .

    Some people even report a shorter refractory period since prolactin is the cause of that phenomenon and l-dopa lowers prolactin

  12. Quote Originally Posted by chedapalooza View Post
    Taking test powder with my amino IV= good/bad idea?? Test powder having200mg mucuna (seed) extract and amino IV w the p5p... Should I be trying to spread these out? Or no issue? Thanks coop
    Not a big deal but just spread em, no need to use test powder pre/intra workout anyway

  13. Quote Originally Posted by chedapalooza View Post
    Taking test powder with my amino IV= good/bad idea?? Test powder having200mg mucuna (seed) extract and amino IV w the p5p... Should I be trying to spread these out? Or no issue? Thanks coop
    Have you been taking it or just starting? I had to quit taking it twice, it's the best laxative on the market.

  14. Quote Originally Posted by todd muelheim View Post

    Have you been taking it or just starting? I had to quit taking it twice, it's the best laxative on the market.
    I've used it two or three times prior and enjoyed it. But yea, definitely loosens you up. I use it fasted and pre workout though so there's not usually much to move til after I break my fast lol. It definitely gives u the mud butt at times tho!
  15. Druboutin
    Druboutin's Avatar

    Just wanted to share this study, which basically says B6 will inhibit the GH benefits from L-Dopa, but will enhance the prolactin lowering effects. Space them if you're looking for sleep/GH. Combine them if you're trying to reduce prolactin.

    Edit: can't post links yet, but it's the "pubmed/20170" extension on the ncbi/pubmed website.

    Here's the excerpt: 500 mg of levodopa was administered orally to 8 normal subjects and induced an increase of growth hormone (GH) and a decrease of prolactin (PRL) secretion. The levodopa-induced GH release was inhibited by an intravenous infusion of pyridoxine; on the contrary, the PRL response to levodopa was enhanced by pyridoxine infusion. This dissociation of GH and PRL responses to levodopa during pyridoxine infusion appears to be mediated by peripheral acceleration of the conversion of levodopa to dopamine. Since dopamine does not penetrate the blood-brain barrier, the enhanced PRL decrease observed during pyridoxine infusion might be explained only on the basis of a mechanism of action exerted by dopamine on extra blood-brain barrier sites.
  16. Druboutin
    Druboutin's Avatar

    Also keep this in mind for your B6 supplementation -- many people suggest taking P5P over B6 due to bio availability, but pubmed 501547 says the following:

    "To investigate if vitamin B6 inhibits prolactin release and to compare this effect to that of bromocriptine, a known suppressor of prolactin release, a study was conducted in male rats. Animals were pretreated with pyridoxine hydrochloride, pyridoxal hydrochloride, saline, or bromocriptine 30 min prior to receiving varying doses of chlorpromazine hydrochloride. Blood samples were obtained 90 min later and analyzed for serum prolactin by a double-antibody radioimmunoassay. Another study involved pyridoxal hydrochloride and saline pretreatments 30 min prior to doses of chlorpromazine hydrochloride. Blood samples collected 60 min later were also analyzed for serum prolactin. Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01). Pyridoxal hydrochloride, another natural form of vitamin B6, failed to suppress prolactin under the conditions of both studies. This investigation may lend support to the concept that pyridoxine hydrochloride partially inhibits prolactin by a mechanism not involving dopamine."

    Essentially, the standard B6 (pyridoxine) will aid in reducing prolactin. P5P (pyridoxal) has no effect on prolactin. Hope this clears up any confusion, I know it did for me.

  17. Thank you for these ^^

  18. Quote Originally Posted by mr.cooper69 View Post
    Not everyone but most users. It's been documented in human studies. Not to mention increased penile girth at rest .

    Some people even report a shorter refractory period since prolactin is the cause of that phenomenon and l-dopa lowers prolactin
    http://www.ncbi.nlm.nih.gov/pubmed/9796623

    "On the other hand, in nine subjects who were younger than 50 years, maximum penile circumference increase showed a significant increment with L-dopa."

    I would like to stress that we DO NOT want anyone conducting before and after logs with photos lol.
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  19. Quote Originally Posted by Druboutin View Post
    Also keep this in mind for your B6 supplementation -- many people suggest taking P5P over B6 due to bio availability, but pubmed 501547 says the following:

    "To investigate if vitamin B6 inhibits prolactin release and to compare this effect to that of bromocriptine, a known suppressor of prolactin release, a study was conducted in male rats. Animals were pretreated with pyridoxine hydrochloride, pyridoxal hydrochloride, saline, or bromocriptine 30 min prior to receiving varying doses of chlorpromazine hydrochloride. Blood samples were obtained 90 min later and analyzed for serum prolactin by a double-antibody radioimmunoassay. Another study involved pyridoxal hydrochloride and saline pretreatments 30 min prior to doses of chlorpromazine hydrochloride. Blood samples collected 60 min later were also analyzed for serum prolactin. Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01). Pyridoxal hydrochloride, another natural form of vitamin B6, failed to suppress prolactin under the conditions of both studies. This investigation may lend support to the concept that pyridoxine hydrochloride partially inhibits prolactin by a mechanism not involving dopamine."

    Essentially, the standard B6 (pyridoxine) will aid in reducing prolactin. P5P (pyridoxal) has no effect on prolactin. Hope this clears up any confusion, I know it did for me.
    This study states that pyridoxal HCL had no effect on prolactin, but it doesn't sound like the same stuff as P5P (pyridoxal-5-phosphate). Any thoughts?

  20. Quote Originally Posted by test112 View Post
    This study states that pyridoxal HCL had no effect on prolactin, but it doesn't sound like the same stuff as P5P (pyridoxal-5-phosphate). Any thoughts?
    They are not the same
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  21. Hey natty, coop, and other reps.


    With the addition of chlorotest to the lineup, I'm thinking of 'making my own ' powerfull which I use regularly from usp. It's just chloro and dopa. They do not disclose how much of each, or what % extract. Can you give your best estimation of how much of dopadex+chlorotest I should use nightly? I use two caps of powerfull (750mg each). If I had to guess, I would say there's about 500mg chloro per cap and 250 dopa.

    Would stacking the analyzed products at night yield similar/better results for prolactin and GH?

  22. I honestly don't know the doses of each in powerfull so you'd be better off asking USPlabs reps

  23. Quote Originally Posted by mr.cooper69 View Post
    I honestly don't know the doses of each in powerfull so you'd be better off asking USPlabs reps
    Based off other formulas it would be safe to ballpark 500mg chloro and 250 dopa per capsule
  

  
 

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