You know, when I worked intermittently on projects for MAN, Joey Rodriguez (company owner at the time) said he intended to make a product centered on the ingredient Agmatine (a polyamine by-product of arginine metabolism), but he alongside many before him had no idea how the hell to market it or whether or not there was any validity. With a lot of discussion with the guys from the original research teams, we just had no idea what level of oral bioavailability would exist - and we STILL DON'T, so it is very likely that 100% of products on the market containing this ingredient are GROSSLY underdosed. I have done many experiments with people taking in up to 5 grams per day, with some suggested benefits - one in particular is the glucose disposable power which made R-ALA a natural combination for the original product launch of Blue Print back in late 2006 / early 2007. For the average 70kg man, an effective dose seemed to be around 1000mg (hence the original dosing we used that kind of started where people were using it in their formulas)...although one has to TRULY know how to best employ GDA supplements to actually see ergogenic benefit - the same can just as easily be suggested for pro-testosterone agents, and how any (if any at all) of these agents would either impact aesthetics or athletics. That said, the average bodybuilder is NOT 70kg and likely requires much more than this dose unfortunately (at the time it was very expensive to source the ingredient as we were the first to market with it, but since the price has dropped dramatically), but still - he too would have to best understand how to employ it in a body composition effort. It's not always the easiest to do.
I am going to re-post the Agmatine slide show here in full so we can discuss some of the benefits in full.