Augmatine

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  1. Does Augmatine have any cortisol lowering ability ????


  2. Today I gave agmatine another shot,
    out of boredoom really, it was arms/abs + full body depletion workout
    long wo with the first part being heavy-ish and the depletion part fast and light
    took a day off from Craze so I took 750mg of Agmatine prewo with 100mg caffeine 30 min
    before the training.

    I can definitely say that Agmatine is NOT for me.
    First it puts me to sleep, second it puts me in a very bad mood,
    it takes my aggression away, it seems to make muscle contraction less intense
    and after the first few sets this last thing was really noticeable.
    Mind/muscle connection is just not there and (something I noticed before but today
    had confirmation) it makes my eyes way too sensitive to light, which makes my head feel
    "heavy"..

    Overall I am pretty sure agmatine is the WORST supplement I've ever taken,
    I genuinely hate what it does to me, awful.. Remaining 40gr of it are heading in the toilet
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions

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  3. I can related to the "puts me to sleep" part. It makes me drowsy too.

    T-Bone and I were discussing this recently.


    Quote Originally Posted by AutoKal47 View Post
    Today I gave agmatine another shot,
    out of boredoom really, it was arms/abs + full body depletion workout
    long wo with the first part being heavy-ish and the depletion part fast and light
    took a day off from Craze so I took 750mg of Agmatine prewo with 100mg caffeine 30 min
    before the training.

    I can definitely say that Agmatine is NOT for me.
    First it puts me to sleep, second it puts me in a very bad mood,
    it takes my aggression away, it seems to make muscle contraction less intense
    and after the first few sets this last thing was really noticeable.
    Mind/muscle connection is just not there and (something I noticed before but today
    had confirmation) it makes my eyes way too sensitive to light, which makes my head feel
    "heavy"..

    Overall I am pretty sure agmatine is the WORST supplement I've ever taken,
    I genuinely hate what it does to me, awful.. Remaining 40gr of it are heading in the toilet
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  4. Quote Originally Posted by Whacked View Post
    I can related to the "puts me to sleep" part. It makes me drowsy too.

    T-Bone and I were discussing this recently.
    Yeah dosing it "solo" I could totally spot that effect, def not nice especially prewo
    Are you still running it? Have you noticed any benefit? 'cause aside from some lil more pump
    i didn't really see anything altho' I didn't use it long enough tho' but I'm cutting everything that
    I'm not 100% sure gives me some improvement, I'm done "guessing" what sups do or are suppose to
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions


  5. No - I stopped as well.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
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  6. Quote Originally Posted by RipdnTxs View Post
    Does Augmatine have any cortisol lowering ability ????
    Oh no, the damage of a spelling mistake in the thread title is spreading lol.

    "Agmatine" = correct. "Augmatine" = no.
    PEScience Representative
    http://pescience.com/insider
    http://selectprotein.com

  7. Quote Originally Posted by Whacked View Post
    No - I stopped as well.
    Ja, not worth it imo

    Quote Originally Posted by bdcc View Post
    Oh no, the damage of a spelling mistake in the thread title is spreading lol.

    "Agmatine" = correct. "Augmatine" = no.
    lol i tried to point out the wrong title before, it bothers me a lot
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions


  8. I'm almost done with mine. I'm not throwing it in the toilet though. It is way too expensive and I don't like to waste things no matter what. Mine should be finished up within the next couple days.

  9. I'm still taking 1.5 grams a day and love it


  10. Quote Originally Posted by StakedCop View Post
    I'm still taking 1.5 grams a day and love it
    Its nice to hear that. I am always looking into new supps for me and adding them to a never ending purchase list. Does this bother your stomach at all in any way. That believe it or not is one of the important things for me. I can deal with feeling sleepy and some other things LOL. Also, how have your results been, ie, pumps, vascualrity, strength etc. And finally, how have your been staked..Sj

  11. Personally I have not had any negatives with agmatine.

    First day I did notice a mood change, and I shat a lot, but lately nothing...
    Hardcore Purus Labs {Rep}
    Lift the fücking weight from the floor, or leave it on the ground. The thoughts are supposed to be daunting. The pain is meant to be tormenting.

  12. Quote Originally Posted by SuppJunkie

    Its nice to hear that. I am always looking into new supps for me and adding them to a never ending purchase list. Does this bother your stomach at all in any way. That believe it or not is one of the important things for me. I can deal with feeling sleepy and some other things LOL. Also, how have your results been, ie, pumps, vascualrity, strength etc. And finally, how have your been staked..Sj
    I'm good brother how you been man? This product really helps with pumps. Not just workout pumps but I feel fuller all day. Nothing crazy but it is very noticeable for me. Vascularity is ok I'm bulking still so I'm not all that vascular at the moment. No strength gains for me but strength isn't a huge concern for me as long as in pushing body to its limit.

    Also no stomach issues. That's a huge factor for me too!! I can't stand a product that makes me sleepy or lose focus and
    I can't say I've had any issues with that either. I always gotta be at the ready lol


  13. These agmatine concerns are overblown IMO. The lack of conclusive evidence and transient agonism are likely due to agmatine's halflife.

  14. Quote Originally Posted by mr.cooper69 View Post
    These agmatine concerns are overblown IMO. The lack of conclusive evidence and transient agonism are likely due to agmatine's halflife.
    How long is the half life for agmatine ???

  15. Quote Originally Posted by Bigugly View Post
    How long is the half life for agmatine ???
    I believe around 10 minutes. However, [some] of its effects are demonstrated to extend beyond that value.

    Despite agmatine’s short (<10 min) plasma half-life (Piletz et al., 2003; Raasch et al., 2002; Roberts et al., 2005), its systemic administration consistently affects a wide variety of CNS-mediated processes (Nguyen et al., 2003).

    Eur J Pharmacol. 2008 June 10; 587(1-3): 135–140.
    Supraspinally-administered agmatine attenuates the development of oral fentanyl self-administration
    Carrie L. Wade,2 Daniel J. Schuster,3 Kristine M. Domingo,3 Kelley F. Kitto,2,3 and Carolyn A. Fairbanks1,2,3

  16. Quote Originally Posted by mr.cooper69

    I believe around 5 minutes. However, [some] of its effects are demonstrated to extend beyond that value.
    Some people are also only using 500mg on work out days only right?
    Hardcore Purus Labs {Rep}
    Lift the fücking weight from the floor, or leave it on the ground. The thoughts are supposed to be daunting. The pain is meant to be tormenting.

  17. Quote Originally Posted by AaronJP1 View Post
    Some people are also only using 500mg on work out days only right?
    500mg is sufficient for many, yes. Despite agmatine's halflife, some of its system effects, most notably vasodilation, persist to a significant degree:

    Agmatine: A novel endogenous vasodilator substance

    • Yuqi Gao1,
    • Bulent Gumusel1,
    • Gabor Koves1,
    • Anand Prasad2,
    • Qingzhong Hao1,
    • Albert Hyman1, 3,
    • Howard Lippton


    "The purpose of the study was to investigate the effects of agmatine, an endogenous clonidine-displacing substance (CDS), on systemic hemodynamics in the anesthetized rat. Bolus intravenous (i.v.) injections of agmatine decreased systemic arterial pressure (SAP) and systemic vascular resistance in a dose-dependent manner. The development of acute tachyphylaxis to the systemic vasodepressor response to agmatine did not induce cross-tachyphylaxis to the systemic vasodepressor responses to bradykinin, isoproterenol and nitroglycerin. The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. The present data suggest that activation of I receptors may represent a novel mechanism of vasodilation in vivo."

  18. Thanks mr Cooper! Good info here.
    RecoverBro ELITE

  19. Since it takes time for the amount of agmatine to build up in the body, would there be any benefit to do a loading phase when starting agmatine use in order to build up the level of agmatine in the body faster? If so, what sort of dosage could beused in a loading period?

  20. I am unsure why all the references to supraspinal and IV admin.

    There is an attenuation of total body agmatine stores as we age (pointed out in an article I did for Joey - then, CEO of MAN back with the launch of Blue Print). It may very well come down to younger individuals not benefiting as much as old. As for pre-workout administration; way back with the original launch for MAN Sports I did back in 2007/2008 and the product Blue Print...I have NEVER suggested this to be the time to dose it. I am uncertain how we have come to this really - possibly a lot of "me too" companies promoting it in this fashion (unsure); just as arginine and any other polyamine has shown - pre-workout is NOT the way to go and I maintain this position, now 5 years later!

    Post-workout, on the other hand in combination with GABA might be exceedingly interesting.


    D_
    Anabolicminds.com Featured Author

  21. Quote Originally Posted by hsk View Post
    Since it takes time for the amount of agmatine to build up in the body, would there be any benefit to do a loading phase when starting agmatine use in order to build up the level of agmatine in the body faster? If so, what sort of dosage could beused in a loading period?
    Outside of sheer pontification; I can say, with confidence, that we simply don't know.


    D_
    Anabolicminds.com Featured Author

  22. Quote Originally Posted by AaronJP1 View Post
    Some people are also only using 500mg on work out days only right?
    Volume of distribution estimates wouldn't support oral dosing this low; we'll chalk that dosing protocol up to a hint of placebo.


    D_
    Anabolicminds.com Featured Author

  23. Quote Originally Posted by AutoKal47 View Post
    Hey Doc,
    the main concern here were some studies posted show Agmatine could potentially halt fat loss being an antagonist for NDMA receptor and agonist for alpha 2.
    Would be nice to hear your take on this

    here's the studies posted bty ssbackwards and
    Sourdough
    Read last line 1 of paragraph 1 of the first quote ("several subsequent functional studies reported that agmatine is not an agonist at this site")...studies have been mixed in this regard and it is just that we know of about 13 receptors that are affected by agmatine; in order to even claim substantial impact to a significant degree in this respect, you'd probably need to take it by the bucket-full from an ORAL standpoint which lends credence to the study discrepency with IV dosing parameters.

    I think boys will be boys stirring up a bit of controversy on an ingredient (can't say as I have heard that before at all - obviously a hint / or a landslide of sarcasm).


    D_
    Anabolicminds.com Featured Author

  24. Quote Originally Posted by RipdnTxs View Post
    Does Augmatine have any cortisol lowering ability ????
    Just as arginine before it; all polyamines (arginine, citrulline, ornithine, putrescine, spermine, spermidine, et al...) do to some effect. To suggest that means we know what to do with it in this regard, I would be lying to you.


    D_
    Anabolicminds.com Featured Author

  25. Can I suggest a thread title change again?

    I agree with those who have said it before me...the thread title disturbs me.

    D_
    Anabolicminds.com Featured Author
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