Here are some links about these issues
Cholestrol/Liver issues
HPTA shutdown
Low estrogen(I had a link about tren causing low estrogen but can't find it) wonder why people take AI's with it
Glucose levels
http://anabolicminds.com/forum/anabolics/38742-lethargy.html?highlight=lethargy
http://anabolicminds.com/forum/anabolics/31740-what-causes-lethargy.html?highlight=lethargy
Bobos comments about low estrogen
http://anabolicminds.com/forum/anabolics/14304-any-truth.html?highlight=lethargy
http://forums.steroid.com/showthread.php?t=182628&goto=nextoldest
Something about Tren causing TSH level to drop and using T3 to combat it
Edit: here is that link about trenbolone and estrogen lowering
http://www.mesomorphosis.com/articles/llewellyn/trenbolone.htm
rise during use. With trenbolone we actually expect a lowering of serum estrogen levels, as it should suppress endogenous testosterone release (the primary substrate for estradiol in men).
Something else from t-nation on estrogen lowering and tren
The Truth About Tren
Q: Some steroid users say trenbolone gives them a crazy sex drive. Others say they get "tren ****" like deca ****. Why the difference?
A: Again, this is really left up to speculation but I'd suspect it’s either stemming from a decrease in estradiol levels (people often forget it too plays a role in sex drive) or that trenbolone has some progestational activity.
As for why some people experience this and some don’t, well, if it’s a decrease in estradiol, some people may have higher aromatase levels and thus it’s not as much of an issue. Or if it’s due to some progestational activity, it could be a matter of some people having a higher receptor content than others.
It’s tempting to side with the latter as there's some direct and indirect evidence supporting the idea that trenbolone may possess some progestational activity. However, it’s completely reasonable to suspect a combination of these two issues to cause the decrease in sex drive, since progestational activity coupled with avid binding to the androgen receptor both suppress LH and, as a consequence, endogenous Testosterone is suppressed, which is the substrate for estradiol formation.
For those who don’t have issues in regard to sex drive or even get a sex drive boost, there would obviously be a lesser amount of progesterone receptor content. Or perhaps estradiol levels remain unaffected—meanwhile, the high androgenic molecule binds to the androgen receptor and we see an increase in sex drive.
The sex drive in general has so many contributing factors, it’s really difficult to narrow it down to one cause. Fluctuations in monoamine levels, androgen and estrogen levels, progesterone, dopamine, prolactin, etc., all in one way or another play a role in sex drive. Aside from that there are still many aspects about the human sex drive which have yet to be figured out. (10-14)