so you wanna know how bad pain killers are for protein synthesis, aye??
From the June 2001 issue of Muscle Media, "Research Update" by David Kennedy.
I interject my commentary to make it easier for the bros here that are not science buffs
Q: "Will using common over-the-counter analgesics like ibuprofen and acetaminophen negetively affect muscle growth?"
A:"Dr. Todd A Trappe abd collegues from the Unervisty of Arkansas for Medical Sciences and the University of California, Berkeley, examined the effect of ibuprofen and acetaminophen on muscle protein metabolism following high-intensity resistance exercise. The researchers randomly assigned 24 males to one of three groups that received either the maximal OTC dose of ibuprofen (1200mg/day), acetaminophen (4000mg/day) or a placebo following 10 to 14 sets of 10 heavy eccentric repetitions on a leg-extension machine..."
so some bros were told to bust their ass doing high-volume negatives on leg extensons and then take some pain killers or a placebo....sounds good.
"....Results showed that post-exercise muscle protein synthesis increaesd by an average of 76% in the placebo group..."
"....but was, disturbingly, UNCHANGED, in the groups taking acetaminophen or ibuprofen...."
AWW CRAP!!....no change in protein synthesis...in other words, the pain killers STOPPED MUSCLE GROWTH....that can't be good
"...These results suggest that both ibuprofen and acetaminophen suppress skeletal muscle protein synthesis following eccentric exercise...and may work through a common mechanism to influence protein metabolism in skeletal muscle."
In other words...it keeps you from growing, AND could use muscle proteins for energy (not good at all)....
So do yourself (and your muscles) a favor and kick the Tylenol and Advil to the curb
This should help a great deal.
LG.