Take it fasted, wait 20 mins, do cardio, wait until about 2 hrs from time of consumption, then eat... in a perfect world
IIRC the half life is about 2.5 hrs and it reaches highest plasma concentration in about 20-40 minutes. (This is all based on Y-HCL, not a lot of human study for a-Yohimbine).
Since I feel the best bang for the buck is to combine Target A2 with Y-HCL, I found a combination of 18mg Y-HCL and 6mg of T-A2 to be perfect -
for me (227lbs). 9mg was too much with the 18mg of Y-HCL.
Be very methodical in your experimentation - too much is not fun.