I have been taking Dermacrine for almost a month and it does/did seem to help my mood, however I have been experiencing moodiness. The first 2 1/2 weeks on Dermacrine, I felt great, but now I've noticed elevated irritability. Also, at night I've started to feel anxious. This leads me to think that a portion of the DHEA is aromatizing. SUP3R DHEA has a different estrogen blocker than Dermacrine, so I'm wondering if that'll work better.