I am taking 50mcg of T3 currently. I am going to be experimenting with NDT (natural dessicated thyroid) which has T1, T2, T3, T4, calcitonin, and combining it with a lower dose of T3 to see if it will be more effective than T3 alone. Last year, I converted from T4 to T3 too well and suppressed my TSH to 0.09 (which is a bit too low) - even better than when I was on T3 alone. Running an AAS like test cyp and deca will prevent the catabolic effects of T3, something I did not have before.
Not on statins nor ever will be. Unless you have genetic tendency (i.e. familial hypercholesterolemia), this can be fixed by diet and lifestyle modification. Will be trying straight niacin in future, probably a much lower dose though, like 50-100mg. No-flush niacin (inositol hexonicotinate) has no effect on lipids [ncbi.nlm.nih.gov/pubmed/23351578].
Regarding the exo HGH, by my taking proper steps, I mean eating right, eating VL carb and not eating any carbs right after a GH injection, I think I can mute the IR. How can I become IR if I keep my carbs <50g? The IR rom HGH can be reversed by eating low carb for a while or by using metformin to decrease the insulin response the body has to carbs for a duration of time to restore the body's sensitivity to insulin. As long as you are getting your glucose levels tested and they are showing fine then you don't have anything to worry about. HGH, as I recall, is also catabolic BIGTIME to adipose tissue to site injections and will keep fat from accumulating in that area. I know this for a fact because I experienced it myself when I used GH 10 years ago, but in minute amounts. Also - I would limit usage to only do a 4-6 mos. cycle. As we already spoke of my stack using test cyp/deca and HGH, I think that if I take more insulin-sensitizing agents like green coffee, ALA, or even metformin during GH injections, that should help reduce any effects of IR.
I need the lipolytic effects and the better protein synthesis that HGH can provide.
Also testosterone itself will help reduce IR: [ncbi.nlm.nih.gov/pubmed/16728551] which will help offset the IR effects from HGH as well.
To sum up, this is what I read:
For the insulin resistance that is possible:
conservative - 300mg of Alpha Lipoic Acid and 200 - 300mcgs of Chromium Picolinate
moderate - 15mg of Actos - a prescription med to increase insulin sensitivity, Glucophage (Metformin) to dispose of excess glucose and increase uptake in muscles. [ncbi.nlm.nih.gov/pubmed/14983408]
aggressive - add a few IU's of insulin to your HGH cycle
I wonder if adding IGF1-lr3 would work in suppressing IR also?
Also, as I posted on earlier - to avoid a prolonged release pattern that can lead the user towards type II diabetes, due to chronic elevations in blood glucose, GH should be pulsed every 4-5 hours, using IM injections as opposed to subq, with at least one day off, every other day. The side effects of GH use can be ameliorated by utilizing the correct dosing protocol.
Supplements: I take handfuls of them daily - all for specific purposes, and many are necessary because I have a genetic methylation defect. It is all based on blood work, never randomly. But since you brought up the issue of muscle cells and that if they are bombarded with certain substances, such will shut down receptor sites to basically protect themselves from damage. - I wonder if so many supps could be clogging them up, making it harder for the liver to process fats. Don't know if this is even possible. I can cycle off some., but I need to stay on the essentials daily. I also use many supplements to help anticoagulate my blood.
What macro amounts and calories would you think I should be at?
I'm thinking this based on these stats:
Age: 53
Ht: 5-7
Wt: 175
BF: 25%-29%
Calories: 1600
PRO: 40% - 160g
CHO: 10% - 40g (or less)
FAT: 50% - 89g
Sort of a semi-keto diet, but the protein is much higher and fats more moderate because I lost some lean mass and gained fat for the same weight. For the last year, I train fasted and only take 10-20g BCAAs to help burn fat stores and don't eat until pwo. But if my cells are impaired as you say, this may be why I can't even burn fat in a fed state.
What are your thoughts on HIIT cardio? When I was much younger, I leaned out quickly doing cardio. Not any longer.
Observation: After drinking a homemade brew today for lowering blood pressure (celery/beet juice/1 tsp pomegranate concentrate, etc.), within 30 min. my BG shot up to nearly 160. I drank a couple oz. of apple cider vinegar and brought it down to 97 within 30 min.
You mentioned that T3 daily is recommended with GH. I've read that T4 is needed, not T3, as HGH increases the conversion rate of T4 into T3.
What I cannot understand is how I could have developed fatty liver and IR from eating clean carbs and whole fruits (not fruit juices). That doesn't happen in a healthy person.
The only cause then could be chronic hypothyroidism over many years leading to decreased insulin sensitivity and then IR. Sound plausible?
[hindawi.com/journals/jtr/2011/152850/]
Since my a1c and FBG have been very normal, but my LDL-P/APO B is still elevated, I wonder if Glucophage XL (extended release metformin) would help restore insulin sensitvity, reducing the amount of glucose my intestines absorb, and turning down my liver's glucose production. Lower blood sugar means lower insulin, which means my body stores less fat, and is now burning my fat stores for fuel! Only problem is that it looks like Metformin can lower T as some studies have shown.
Also -for an AI, would you recommend raloxifene over adex?
Bottom line is that your body can't store fat unless your blood sugar levels are elevated. So you don't have to count calories until you get to really low body fat levels.
What do you think?
THe thing with T3 is not to take too much of it, just take enough to do the job. THe main issue is this...does T3 really gets to the cells and does the cells respond to it?
From my understanding muscle cells and other cells in general if they are bombarded with certain substances it will shut down receptor sites to basically protect themselves from damage. The entire approach that worked for me was to
1. reduce glucose thus reducing insulin release and increase glucagon production and help receptor and cell healing
2. thin out the blood and lower the signal load to these cells, like ldl particles, trigs, chemicals.
So, basically eating tons of vegetables, goods fats, low carbs daily for months at the time along with vits and minerals did the trick. At one point I was eatin so low carb that my liver was dumping a bunch of glucose in my blood stream. THat;s a good sign, then you know the liver is steping up its processes to make glucose instead of making trigs.