On a counter note:
On another forum (Longecity, of course) people are always looking into how to create a more effective stack. And many of those people experiment with ADD and narcolepsy drugs and medications. They want something to give them the efficient focus, brain energy and concentration without the negative sides of the amphetamine type meds or amphetamines themselves. Most strong attention drive comes through the dopamine neurons and receptors in the brain, which is the direct reward circuits in the brain. They have been experimenting with health type supplements that increase cAMP and keep it from being depleted quickly in the brain. Forskolin strongly increases cAMP, and different PDE4 inhibitors that keep cAMP from being depleted. The PDE4 inhibitors include artichoke extract, quercetin, perhaps grapefruit juice, and several others. BE CAREFUL WITH THESE IN COMBINATION. They are used as health supps but in combination are quite powerful for the brain. I produced negative results with my experiment using 1 Stablon, 1 artichoke cap, and 20 mg of forskolin actives. These were fairly low doses. I've also read that aniracetam plus these give negative results. It might be interesting to try some forskolin along with AndroDrive, but I'd keep the amount of forskolin actives low at first, and would depend on the grapefruit juice for any PDE4 inhibitor effects.
All this stuff is involved in the direct systematic logic, analytical, dopamine, beta wave side of learning.
What they are searching for is a sustainable focus stack for analytical problem solving, attention, focus, and sharp memory increases (without using memory tricks).
This stack should not burn the user out over time. A couple of top brain scientist have been searching this area for it's LTP (long term potentiation of memory) type effects, but they are using drugs of course. The scientists have gotten incredible results searching these directions for LTP on small life forms. You might say this is one of the most promising searches for something like a science fiction like drug to increase cognition in the classic sense. LTP is where short term memory becomes long term learning. This is an cutting edge area, so pioneer caution is necessary.
This is all about increasing DLPFC activation, or strong working-memory. Yet DLPFC activation gets in the way of creativity as it inhibits creativity. There is a tradeoff between creativity and efficient problem solving and intense attention in the Beta Wave section. People that practice improv humor actually practice shutting down the DLPFC, so they can be more spontaneous.
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The people on Longecity don't seem to be aware of the conflict between the classical dopamine,logical, analytical side of things and the more visionary, and creative side of things. More likely they don't care and see efficient problem solving as the "real" cognition. But what if one is greedy and wants both -- not possible???
Obviously any weight trainer knows the answer to this one. You cycle stacks, and you work on your working memory analytic side sometimes, and your broad scope, insight, and visionary side other times, and use different cognition stacks for each. I would like to try AndroDrive along with forskolin and maybe something like resveratrol (as resveratrol is a very mild PDE4 inhibitor) with coffee as an add-in. This will be my analytical focus stack.
I like aniracetam with something like ashwaganda and some other relaxing noots as my creative stack so far.
