my friend did a log where he would sit in a hot tub for 20 minutes after workouts to activate these HSP. I think they can only be activated at a certain temperature. I was not aware caffiene did this. any studies?
He had a good idea..I would not trust any supplement to have this effect
Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading.
* Selsby JT,
* Rother S,
* Tsuda S,
* Pracash O,
* Quindry JC,
* Dodd SL.
Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.
Skeletal muscle reloading following disuse is characterized by profound oxidative damage. This study tested the hypothesis that intermittent hyperthermia during reloading attenuates oxidative damage and augments skeletal muscle regrowth following immobilization. Forty animals were randomly divided into four groups: Control (Con), Immobilized (Im), Reloaded (RC), and Reloaded and heated (RH). All groups but Con were immobilized for seven days. Animals in the RC and RH groups were then reloaded for seven days with (RH) or without (RC) hyperthermia (41-41.5 degrees C for 30 min on alternating days) during reloading.
Heating resulted in ~25% elevation in HSP expression (p<0.05) and an approximate 30% greater soleus regrowth (p<0.05) in RH when compared to RC. Further, oxidant damage was lower in the RH group when compared to RC as nitrotyrosine and HNE was returned to near baseline when heating was combined with reloading. Reduced oxidant damage was independent of antioxidant enzymes (MnSOD, CuZnSOD, Cat, GPX, GRX). In summary, these data suggest that intermittent hyperthermia during reloading attenuates oxidative stress and improves the rate of skeletal muscle regrowth during reloading after immobilization. Key words: oxidant stress, heat shock protein, antioxidant, oxidative stress, hypertrophy.