ironically i actually was interested in the effects of oral formestane back when dinoii was running his clinicals...this is when bulk formestane was relatively cheap[5gms-$5]. i followed his protocol of a gm a day, after 2 weeks i realized that even at a gm a day effects were not as good as 200mg daily of td formestane. at a gm a day versus 200mg a day i realized that oral formestane was just not effective enough to be worth the cost and effort of downing a not so pleasant tasting ingredient.You said formestane is not effective orally. The evidence in that link says you are wrong. There has never been a single in vivo study on transdermal formestane. And intravenous administration is nothing like transdermal application.
no one ever said that td is or was equal to intravenous injection, merely that it was the method used due to the poor bioavailability of oral. the point being that the poor bioavailibility of formestane is well established.
i will take my 1st hand experience over studies any and everyday of the week...studies are usually sponsored and the people running them or sponsoring them have a vested interest in the outcome.