I've never seen a fat burner with 29 active ingredients. What the hell is this supposed to do, aside from using your body to reenact the alien chest burst scene?
Supplement Facts
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3.5" diiodo L-thyronine 200mcg
Is this a real product or a list you put together? That is indeed one heck of a list my man.
Let's look at:
3,5-Diiodo-L-Thyronine (T2)
It is not worth the proper effective dose due to the sides being similar to T3.
"Although the ability of T2 to increase metabolism is not in doubt, it is not evident from the published studies what conditions allow for its safe and effective use in humans. This is due in part to the lack of comprehensive human studies, but it is also the result of the fragmented information available in the literature. Published studies often focus on different biochemical or physiological endpoints while using different experimental designs, models, and T2 doses. There is also a considerable bias in the literature towards the beneficial effects of T2, leaving its potential deleterious consequences insufficiently explored. If we consider that its thyromimetic effects may extend to many organs, there is a significant possibility that T2 administration may result in long-term undesirable effects.
In one of the most complete studies available, published in the current issue of Endocrinology (11), Wenke Jonas and investigators in the laboratories of Joseph Kohrle and Annette Schurmann used a mouse model of obesity to analyze the physiological effects of T2. In their thoughtfully designed, carefully performed, and thoroughly discussed experiment, the authors treated obese mice for 2 and 4 weeks with 2 different daily doses of T2 or with a supraphysiological dose of T3 and measured a number of metabolic and physiological endpoints during and after the treatment.
The higher dose of T2 used was 80 times that of T3. Thus, it allows for its estimated lower affinity for the TH receptors, assuming that the affinity of T3 for the receptors is indeed 100 times that of T2 (8). This high dose of T2 essentially mimicked all the physiological effects obtained with the T3 dose. These effects included suppression of the HPT axis, decreases in fat mass, serum leptin and cholesterol, and increases in lean mass, food intake, and hepatic expression of TH-dependent genes relevant to lipid metabolism (see summary of results in Table 1). After 4 weeks, this high dose of T2 also caused cardiac hypertrophy and resulted in elevated metabolic rate and body temperature. These results demonstrate that at a dose that corrects for its decreased affinity for the TH receptor, T2 is capable of producing the same biological effects as T3.
Summary of the Effects Observed by Jonas et al (11) in T2-Treated Obese Male Mice vs Untreated Controls
At the lower dose, however, the authors found that T2 did not reduce body weight, cholesterol, or fat mass. Nor it did change hepatic gene expression profiles. However, this low dose of T2 exerted a profound effect on the HPT axis, resulting in a marked reduction in the serum levels of T4 and T3, and a significant decrease in the pituitary expression of the TSH β-subunit. These results suggest a preferential effect of T2 on the HPT axis, and this occurs at least at the pituitary level."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272398/