Interesting. I read trest doesn’t convert to DHT. I assumed that would mean it’s friendly on the hairline.
It doesn't convert to DHT but it is still highly androgenic. DHT is not the only androgen that binds to the AR in the scalp. If you were to use large doses of Testosterone, and at the same time take a potent 5aR inhibitor like Dutasteride, even though you are eliminating a lot of the 5aR enzyme in your body, and thus DHT, you still have high doses of Test floating around. It too will bind to the AR and activate cellular transcription. The binding affinity of Test is just less than DHT in the scalp and prostate, and the type of specific gene transcription will also differ depending on the hormone and which receptor/gene is being activated.
CLIFFS NOTES: androgens other than DHT can negatively impact your hairline depending on the environment created by your cycle.
You'll likely be fine with a low dose. Some people, like me, are just highly susceptible to androgen-induced MPB.
I knew adding trest would be a stretch for me. Honestly I’ll probably just run the lgd without a base. I don’t think it’s necessary with SARMS. People rarely feel symptoms of suppression while on them.
You might regret not having something mild on hand to help with energy on cycle. There are plenty of threads on this forum with people having horrible lethargy on LGD, and feeling VERY suppressed on a number of different SARMs from LGD to Ostarine and beyond; We all respond differently. If you have no prior experience with LGD, and I'm assuming here, you'd be smart to prepare for all of the possibilities, or atleast have funds available to add something like Dermacrine into the mix should the need arise. I don't have any lethargy issues with LGD without a base but I do feel better with a mild base compound.
And an AI is also probably unnecessary. I’ve heard a tiny fraction of SARMS users get estrogen related sides, but really I don’t know how that’s possible.
Probably unnecessary to use.....but not unnecessary to have on hand. If you are cycling, you should always have an AI on hand just in case. Better to be have and not need then to need and not have.
Food for thought. I've dealt with a lump on cycle twice now. Both times on LGD. In a situation like that, mild use of both a SERM and an AI is your best line of defense. If you've been cycling long enough, nothing will surprise you....
It's possible because of SHBG, bound versus unbound hormones, hormone imbalances, changes in binding affinity from altered hormonal profiles, changes in receptor regulation, and for many other reasons.
Less likely to occur does not mean
will not occur.
You are literally the first person I have heard that said trest is bad for libido. I was like a porn star on it.
If you read back in old Trest threads over the last 2+ years you will see that there are a few guys that have had similar experiences to mine. Certainly not the norm, but possible nonetheless. Trest was great in all other areas, though.
https://www.ncbi.nlm.nih.gov/pubmed/6371845