look, it comes down to this.
whether you are talking ph's, steroids, or "prosteroids" etc.
generally speaking... the more profound the effect of ANY substance, the greater the sides/risks.
that is pretty much true across the board. when a compound comes out that has very high sides AND pretty mediocre effects, it generally leaves the market, or becomes rare/unpopular. the perfect example is methyltest (note i said methyltest, NOT methy-1-test).
while methyltest is useful for competitive pl'ers/wl'ers during comp's other than that, it's just not effective enough to justify the sides.
frankly, this cost/benefit equation holds true with most NON-steroidal products as well. cars, food, whatever. generally speaking, the market works such that there has to be added value to justify added price (or people won't buy it), and/or added benefits to justify added risks.
the market in this sense is "efficient". and steroidals are no different.
now, in a very small market, where there are constantly new products and a small user base (think methyl-ph's) there is going to be more market inefficiency than in a hyooooge market, which can be an advantage to a KNOWLEDGEABLE consumer, but the concept generally holds true OVER TIME.
if a substance comes out with HIGH risk, and little benefit it falls by the wayside. if a substance comes out with HIGH benefit and low risk, it will supplant that high risk, high benefit substance - generally speaking.
that's how markets work. PH's are no different.
at this point, with ESTABLISHED compounds, everyone knows what works. in the methyls, m1-t is simply king. exceptionally cheap, extremely effective, and moderate risk/sides (lethargy, cramping, etc). it has stood the test of time, imo. ditto, in injectable/transdermals with 4-ad. it simply WORKS. methyl-di was all the rage due to PROSPECTIVE benefits, but since it hasn't worked out like suspected, it has simply fallen from favor.
in the end, the consumer wins.
if you don't like the risk of methyls, then don't use them. simply put, the SAFEST AND BEST way to take PH's is injectable ASSUMING you know how to make a sterile compound - low hepatotoxicity issues (compared to methyls esp) , lots of bang per mg, lots of bang per $$$, no messy gels, and more convenience (5 minutes to inject and you're done. you don't have to time your showers like with transdermals, etc.)
you are going to pay more to use transdermals, since you get less %age of the compound available.
methyls are so ridiculously cheap (especially m-1-t in bulk powder form), but if you don't like the risks, then choose other option.
and don't even think about ANY PH without proper PCT ***on hand***. much of the risk of these substances comes from improper planning and/or response to sides when they occur.