plotting release of different esters

chasec

Pityin' fools since '81
i've searched for the last 2 hours and can't find what i'm looking for. i'm trying to plot how quickly various test esters are released into the bloodstream. i know i've seen it here before, but i'll be damned if i can find it. in the end i'd like to have a graph in excel that shows testosterone levels in the blood of various esters plotted as a function of time. any help would be appreciated. i think skye posted a year or 2 ago, but i can't find it for the life of me.
 
chasec said:
i've searched for the last 2 hours and can't find what i'm looking for. i'm trying to plot how quickly various test esters are released into the bloodstream. i know i've seen it here before, but i'll be damned if i can find it. in the end i'd like to have a graph in excel that shows testosterone levels in the blood of various esters plotted as a function of time. any help would be appreciated. i think skye posted a year or 2 ago, but i can't find it for the life of me.
here you go. oringal post is Invalid Link Removed if you need it
The actually calculations are easy. The general form for doing this is MgDL = MgD * (1/2)^(D/HL). MgD is milligrams in depot, MgDL is milligrams in depot left, D is days, and HL is the half-life in days. If your mathematically inclined you can also do in logs but I am lazy and this is close enough. So say you took a shot of 800mgs Testosterone Cypionate, which has a half life of 12 days, on Monday, by Sunday you would have 800*((.5)^(7/12)) or 534mg left in the depot. 800-534=266mg that you actually got that week from that shot. If you took another 800mg shot on the following Monday you would (504+800) *((.5)^(7/12)) or 870 left in the depot at the end of week two. 1304-870=434 that you actually got to use during week two and so on. As you can see the long esters take quit a bit of time to get to the weekly dosage. Please note that the calculation for week two starts out with D being 8 instead of 7, hence the 504 instead of the 534.
 
:frustrate i have to be a member to read it, and registering has been disabled by the admin's over there. any chance you could copy and paste it? or is what you've allready posted all that's relevant?
 
I believe I have already posted a copy of that somewhere around here. Try searching for half lives or half life...I really can't remember...I will try and find it for you.
 
Here is a good article on esters I stumbled upon...not really what you are looking for though...
Invalid Link Removed

I did find where I had copied Skye's post, but it was only the part with the calculations...so with no regard for bandwidth.. :D ...here is the entire post.

Originally Posted by Skyefire on Superior Muscle
[font=verdana, arial, helvetica]This is for the new people and really anyone that is interested. There is a lot of misconceptions about what esters are, do and how they should be used. For the first two questions I have found no better article then this one Invalid Link Removed Be aware that while there is a lot of truth to saying that “test is test� or that the changing the ester of the hormone doesn’t change it that is NOT entirely true. The properties do change some with the type of ester used. For instance Testosterone Propionate is widely believed (have notice this myself) to cause you to hold less water then an equivalent amount of Testosterone Enanthate, even if the Testosterone Propionate is injected every day and the Testosterone Enanthate twice a week. Another good example is Trenbolone. An experienced body builder might run 100mg every day of the acetate ester as a maximum but will not get away with running 700mg of the enanthate. So obviously the esters do effect how the drug works to some degree.

A couple of things about half-lives that need to be considered for the following discussion. First is that the actually esters themselves do not determine the actually half-life. The actual half-life is determined by the solution as a whole. The type of oil, amount and types of solvents all contribute to the half-life of a product. For instance the half-life of Testosterone Enanthate is said to be 10 days. However, by using a polyhydric alcohol along with benzyl alcohol and a fast absorbing oil I can reduce that to about 8 days. On the other hand I make a solution that has very little benzyl alcohol and a healthy amount of benzyl benzoate with slow absorbing oil I can get 12 days or better. Testosterone base is another good example. Using a polyhydric solution it is absorbed in 12 hours or less, in a slow absorbing solution that can be made as long as 36 hours. That is the difference between injecting 2 to 3 times a day and once a day. So the manufacture (or how you made it) will make up to a 50% difference in what the actual half-life is.

As for how the longer esters should be ran, well that is as always, a matter of debate. This disclaimer if for the rest of the paper if I can call it that: All this is a matter of my opinion and does not constitute medical or any other kind of advice. This is all role-playing anyways. Also while I am on the soapbox please feel free to disagree and debate the information in here BUT PLEASE STATE WHY. By this I mean make an argument on the subject, don’t just state your opinion on the matter. Additionally I like studies and appreciate them but by themselves they do not make an argument. Your interpolation of them does.

First off it would seam that a lot of people are not aware of how to calculate the dosages they are receiving from a long estered steroid. The term “kick in� is often used to describe the build up period of the depot in the body. This build up period is a result of two things, one being the time the actually hormone needs to start working or for the body to react to it. The second is the time and doses needed for the depot to build up to the point ware the amount taken is the same as the amount released from the depot. For the purposes here I am going to say that the steroid “Kicks in� at the point where 75% of your weekly dosage is released to the body from the depot.

The actually calculations are easy. The general form for doing this is MgDL = MgD * (1/2)^(D/HL). MgD is milligrams in depot, MgDL is milligrams in depot left, D is days, and HL is the half-life in days. If your mathematically inclined you can also do in logs but I am lazy and this is close enough. So say you took a shot of 800mgs Testosterone Cypionate, which has a half life of 12 days, on Monday, by Sunday you would have 800*((.5)^(7/12)) or 534mg left in the depot. 800-534=266mg that you actually got that week from that shot. If you took another 800mg shot on the following Monday you would (504+800) *((.5)^(7/12)) or 870 left in the depot at the end of week two. 1304-870=434 that you actually got to use during week two and so on. As you can see the long esters take quit a bit of time to get to the weekly dosage. Please note that the calculation for week two starts out with D being 8 instead of 7, hence the 504 instead of the 534.

That leads us to the proper way to cycle long esters. I can not count the number of times I have seen people suggest a Testosterone Cypionate with Boldenolone Undecylenate (test cyp/EQ) cycle. The problem is that a lot of people recommending this are saying 8 weeks. In my opinion this just doesn’t cut it. It takes 4 weeks for the Testosterone Cypionate to “kick in� and 6 weeks for the Boldenolone Undecylenate. This means that you would actually have only about 3 to 4 weeks at the intended dosage. That is including the natural ramp down of the esters. The below is the results of a quick spreadsheet I did for this. Sense the Boldenolone Undecylenate is the longer ester that is the one I will be working with. This is for 400mg a week for 8 weeks.

______Total _____actual ______%of dosage
______depot ____dosage _____released
Wks. _in body ___weekly ______from depot

1 ____400 ______102 ________25.48%
2 ____686 ______175 ________43.68%
3 ____890 ______227 ________56.69%
4 ___1036 ______264 ________65.99%
5 ___1140 ______291 ________72.63%
6 ___1215 ______310 ________77.38%
7 ___1268 ______323 ________80.77%
8 ___1306 ______333 ________83.19%

As you can see you only get above 300mg at week 6. Please note that it take twice as long to ramp up as down so the minimum time it take for the Boldenolone Undecylenate to clear is 3 weeks. Now if we increase the cycle time to 12 weeks thing look a little different.

______Total _____actual ______%of dosage
______depot ____dosage _____released
Wks. _in body ___weekly ______from depot
9 ____1333 _____340 ________84.92%
10 ___1353 _____345 ________86.16%
11 ___1367 _____348 ________87.05%
12 ___1377 _____351 ________87.68%

Now we have almost 8 weeks at near the intended dosage. If you include week 13:

______Total _____actual ______%of dosage
______depot ____dosage _____released
Wks. _in body ___weekly ______from depot


13 ___765 ______195________ 48.69%
14 ___570 ______145 ________36.29%
15 ___425 ______108 ________27.04%
16 ___316 _______81 ________20.15%
17 ___236 _______60 ________15.02%
18 ___176 _______45 ________11.19%
19 ___131 _______33 _________8.34%
20 ____98 _______25 _________6.22%

And it might even look better if we ran 16 weeks. Please note that this is the same for any steroid with a half-life of 16.5 days. It does not matter. Swales has also said that

quote:
--------------------------------------------------------------------------------
when serum androgen levels drop to a concentration roughly equal to 200mg of testosterone per week
--------------------------------------------------------------------------------

you should start your PCT. I believe that he means any repressive gear so you would have to include most any gear left in your system if you didn’t finish with testosterone.

The other opinion is to front load the steroid in question.. This is the process of taking a great deal of the steroid during the first week or two in order to avoid having to wait for the build up to occur. As you might guess this is controversial process but it does work. For this example I am going to use the EQ again at the same dosage but this time I am going to front load 1.2 grams of EQ as 300mg ED for 4 days the first week. To make life simple I entered this as a single dose on the spreadsheet but the error this produces is small and not important to this discussion.

______Total _____actual ______%of dosage
______depot ____dosage _____released
Wks. _in body ___weekly ______from depot


1____ 1200_____ 306 ________76.43%
2 ____1257 _____320 ________80.09%
3 ____1299 _____331 ________82.71%
4 ____1328 _____338 ________84.58%
5 ____1349 _____344 ________85.91%
6 ____1364 _____347 ________86.87%
7 ____1375 _____350 ________87.55%
8 ____1382 _____352 ________88.04%
9 ____1388 _____354 ________88.39%
10 ___1392 _____355 ________88.64%
11 ___1394 _____355 ________88.81%
12 ___1396 _____356 ________88.94%


Now as you can see this is a hell of a difference. No real ramp up time just the time it take for the body to respond. This is also a good way to get the test flu, so be forewarned.

Below is a quick reference of the esters and there respective half-lives.

Formate 1.5 days
Acetate 3 days
Propionate 4.5 days
Butyrate 6 days
Valerate 7.5 days
Hexanoate 9 days
Caproate 9 days
Isocaproate 9 days
Heptanoate 10.5 days
Enanthate 10.5 days
Octanoate 12 days
Cypionate 12 days
Nonanoate 13.5 days
Decanoate 15 days
Undecanoate 16.5 days
[/font]
 
Well I think I am starting to suffer insomnia from the tren, I couldnt get to sleep till past 3am last night and woke up before 6am wide awake and couldnt go back to sleep. So what was I thinking about lying there wishing I was sleeping? How much test is in me:thumbsup: So here is a 10 week cycle I did for test enanthate @ 600mg/week for 10 weeks, you might want to double check some of the numbers, it was pretty early this morning. I figured in a 10 day halflife for the test enan.

Week Total Depot/ Depot in body
1 600mg/ 231mg
2 945mg / 363mg
3 1142mg / 439mg
4 1257mg / 483mg
5 1322mg / 508mg
6 1359mg / 522mg
7 1381mg / 531mg
8 1393mg / 535mg
9 1400mg / 538mg
10 1404mg / 540mg

Stop Test enanthate

11 806mg/ 310mg
12 463mg / 178mg
13 266mg / 102mg

Hope that is correct, I found it pretty interesting. If you want to figure the amount of test enanthate in the body at a different dosage than what I gave, here are the percentages of the active dosage each week:

Week Percent active test
1 38.5%
2 60.5%
3 73%
4 80.5%
5 85%
6 87%
7 88.5%
8 89%
9 90%
10 90%

So if you were running a gram of test a week and wanted to know how much is active by week 3, take 1000mg* 73%=730mg testosterone. Those percentages will only work for enanthate esters figuring in a 10day half life.
 
Skye said:
one of these days I am going to write a program to do this. assuming I ever get time

Ahhh, the truly gifted rarely have enough time... it will be eagerly anticipated :type:
 
Are you running your decay's separate for each dosage for all dosages through the points in time and then
subtotally?....

When I model these in excel... I do each individual dosage parameter into its own spindown and then take
the cumulative sum.... it makes for a fairly messy spreadsheet - particularly as the # of distinct injections
grows..



Neuromancer said:
Here is a good article on esters I stumbled upon...not really what you are looking for though...
Invalid Link Removed

I did find where I had copied Skye's post, but it was only the part with the calculations...so with no regard for bandwidth.. :D ...here is the entire post.

[/size][/font]
 
My model spinning down 600mg/ 12Day t1/2 (actually its dosage independent -- this % that is so its immaterial here)
an individual weekly dosage decayed independently and then subtotalling... making by week 12 a rather large matrix. I get the following #s which demonstrate the quasi-static depot dosage concept that was being outlined in a prior thread...

Week - Mg decayed in week / Mg administered in week
Day 1 6%
1 Week Out 33%
2 55%
3 70%
4 80%
5 87%
6 91%
7 94%
8 96%
9 97%
10 98%
11 99%
12 99%

This discussion would be easier if excel attachments were permitted on the site.........

crazydoc1 said:
Are you running your decay's separate for each dosage for all dosages through the points in time and then
subtotally?....

When I model these in excel... I do each individual dosage parameter into its own spindown and then take
the cumulative sum.... it makes for a fairly messy spreadsheet - particularly as the # of distinct injections
grows..
 
for my purposes i am only interested in comparing the release of 2 different esters, Propionate and Enanthate. The math i had done was with the decays for each injection seperate and than totaled at the end. It did become cumbersome with the EOD injections of Propionate. However what i got in the end answered my questions well enough to warrant the time spent.
 
crazydoc1 said:
My model spinning down 600mg/ 12Day t1/2 (actually its dosage independent -- this % that is so its immaterial here)
an individual weekly dosage decayed independently and then subtotalling... making by week 12 a rather large matrix. I get the following #s which demonstrate the quasi-static depot dosage concept that was being outlined in a prior thread...

Week - Mg decayed in week / Mg administered in week
Day 1 6%
1 Week Out 33%
2 55%
3 70%
4 80%
5 87%
6 91%
7 94%
8 96%
9 97%
10 98%
11 99%
12 99%

This discussion would be easier if excel attachments were permitted on the site.........
That is more work then I put into, any chance you'll post that sheet?
 
I actually have a few other models like this done with Mon-Thurs models through 12 weeks
and also a Prop EOD Model....

I just need them to open up xls attachments and I'll post what I have for everyone.... I think a spreadsheet with the calculations there for someone to see the derivations is really worth a 1,000 words here...




Skye said:
That is more work then I put into, any chance you'll post that sheet?
 
i'll pm bobo now...

oh by the way, i got the spreadsheet and it's very well thought out. from what crazydoc mailed me, i went ahead and did a comparison of eod prop and test e shot 1 and 2x week.
 
Can someone plz help me out here.In the formula MgDL=MgD*(.5)^(D/HL); what does the ^ symbol means.:think:

Going to the Max
 
Changing the T1/2 is fine.. changing the dosages are find as long as they are all in the same
and at the same intervals as the model had originally... to calculations are not setup to let you do ramp ups and ramp downs with changing dosages .. and bi-weekly would require
extrapolation to far more spin down iterations..

I just want to make sure that you didn't modify it in a way that its providing inaccurate information. Essentially these calc are iterations with a running summation...

chasec said:
i'll pm bobo now...

oh by the way, i got the spreadsheet and it's very well thought out. from what crazydoc mailed me, i went ahead and did a comparison of eod prop and test e shot 1 and 2x week.
 
Dear Lord......... its an indication of an exponent...... 0.5 to the "power-of" (D/HL)..

biomax said:
Can someone plz help me out here.In the formula MgDL=MgD*(.5)^(D/HL); what does the ^ symbol means.:think:


Going to the Max
 
crazydoc1 said:
Changing the T1/2 is fine.. changing the dosages are find as long as they are all in the same
and at the same intervals as the model had originally... to calculations are not setup to let you do ramp ups and ramp downs with changing dosages .. and bi-weekly would require
extrapolation to far more spin down iterations..

I just want to make sure that you didn't modify it in a way that its providing inaccurate information. Essentially these calc are iterations with a running summation...
oh, i understand. i didn't copy and paste new data into the spreadsheet. i just observed how you had it all setup and did my own. it's not to give to others either; it's just so i can make the most efficient use of the gear i have with respects to achieving peak blood levels and maintaining them with the least # of pins necessary. thanks for all your help.
 
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