Apigenin: Estrogen blocker?

GreenMachineX

GreenMachineX

Well-known member
“It was shown that high doses of apigenin (50 μM) do not display estrogen-like activity and can suppress ER activation by 17β-estradiol.”

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For those that haven’t seen all my posts regarding issues in my TRT, I’ve been experiencing low estrogen-like effects for almost a year, despite having even having an estrogen sensitive result of 27 about 2 months ago. 6 months ago it was measured at 7 if I recall correctly, but definitely less than 10. Could the above study be why?

About 1 month after starting a particular multivitamin, a whole slew of effects began and I’ve never quite nailed down why. I started it in 2016 in November or December and beginning of February my first dizzy spell and heart rate/palpitation/chest flutter craziness began.

Anyone have any thoughts?

FWIW, I’ve stopped absolutely every supplement as of 48 hours ago in an attempt that maybe it is anything I’m taking.
 
Can find this interesting if it has the benefits it claims.
 
Also, according to selfhacked:

“2) Apigenin Interacts Negatively with Hormone Replacement Medicine
Apigenin can change the levels of estrogen in the body. MPA is for post-menopausal women’s hormone replacement. MPA and apigenin can interact to increase tumors and cause breast cancer (R).”

If this is the culprit, I wonder how long it’ll take for it to leave my system (been taking it a year!), and how long the E receptors will resensitize or whatever. The extreme panic/anxiety with this is debilitating.
 
Yes, I've seen it is a potential estrogen blocker. It has a ton of positive effects. I can't imagine you would be taking any dose of it that would powerfully suppress estrogen, but I could be wrong. I personally have taken doses in the 500-1,000 mg/day range for a couple months at a time and at those doses I noticed nothing negative and some very positive effects. Although, another potential issue is that, if you have low T and are on TRT for that - you may already have low levels of aromatase and apigenin, I believe, is also an aromatase inhibitor. How much apigenin is in the product you were taking though? I mean, it's a natural compound found in many culinary herbs and veggies....

Still, hard to say - what other supplements were you taking? What multi-vitamins? Any other blood work you care to share?
 
It was only 5mg in that product, not a lot, but I’m running out of things to exclude. I’m still hoping it’s something in my stack. I’ll update with those in my other thread regarding estradiol issues.

I’m not even sure the chest flutter nightmare is estrogen related, but I’ve had plenty of ekgs, an echo and wore a heart monitor for a week that found nothing. The echo showed mild mitral valve prolapse but the cardiologist said it was nothing. Getting desperate for an answer.

I do have low T naturally and am on TRT. Figuring out my AI dose has been a nightmare too and have recently found out I don’t even need one.
 
GreenMachineX said:
It was only 5mg in that product, not a lot, but I’m running out of things to exclude. I’m still hoping it’s something in my stack. I’ll update with those in my other thread regarding estradiol issues.

I’m not even sure the chest flutter nightmare is estrogen related, but I’ve had plenty of ekgs, an echo and wore a heart monitor for a week that found nothing. The echo showed mild mitral valve prolapse but the cardiologist said it was nothing. Getting desperate for an answer.

I do have low T naturally and am on TRT. Figuring out my AI dose has been a nightmare too and have recently found out I don’t even need one.
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Well, I guess that would make sense, if you don't need an AI you probably have low test to estrogen conversion because you have low aromatase. It could be a combination of ingredients.

Do you have a link to the other thread?
 
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